The Gut Microbiota and Liver DiseaseSummary
The leaky gut hypothesis links translocating microbial products with the onset and progression of liver disease, and for a long time they were considered one of its major contributors. However, a more detailed picture of the intestinal microbiota contributing to liver disease started to evolve. The...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-05-01
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| Series: | Cellular and Molecular Gastroenterology and Hepatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352345X15000648 |
| _version_ | 1817979871283904512 |
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| author | Cristina Llorente Bernd Schnabl |
| author_facet | Cristina Llorente Bernd Schnabl |
| author_sort | Cristina Llorente |
| collection | DOAJ |
| description | The leaky gut hypothesis links translocating microbial products with the onset and progression of liver disease, and for a long time they were considered one of its major contributors. However, a more detailed picture of the intestinal microbiota contributing to liver disease started to evolve. The gut is colonized by trillions of microbes that aid in digestion, modulate immune response, and generate a variety of products that result from microbial metabolic activities. These products together with host-bacteria interactions influence both normal physiology and disease susceptibility. A disruption of the symbiosis between microbiota and host is known as dysbiosis and can have profound effects on health. Qualitative changes such as increased proportions of harmful bacteria and reduced levels of beneficial bacteria, and also quantitative changes in the total amount of bacteria (overgrowth) have been associated with liver disease. Understanding the link between the pathophysiology of liver diseases and compositional and functional changes of the microbiota will help in the design of innovative therapies. In this review, we focus on factors resulting in dysbiosis, and discuss how dysbiosis can disrupt intestinal homeostasis and contribute to liver disease. Keywords: Dysbiosis, Leaky Gut, Alcoholic Liver Disease, NASH, NAFLD, Cirrhosis, Microbiome, PAMPs |
| first_indexed | 2024-04-13T22:47:40Z |
| format | Article |
| id | doaj.art-a4249605d4784f039ce41f04b0712f82 |
| institution | Directory Open Access Journal |
| issn | 2352-345X |
| language | English |
| last_indexed | 2024-04-13T22:47:40Z |
| publishDate | 2015-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cellular and Molecular Gastroenterology and Hepatology |
| spelling | doaj.art-a4249605d4784f039ce41f04b0712f822022-12-22T02:26:20ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2015-05-0113275284The Gut Microbiota and Liver DiseaseSummaryCristina Llorente0Bernd Schnabl1Department of Medicine, University of California San Diego, La Jolla, and Department of Medicine, VA San Diego Healthcare System, San Diego, CaliforniaCorrespondence Address correspondence to: Bernd Schnabl, MD, Department of Medicine, University of CaliforniaâSan Diego, Biomedical Research Facility 2 (BRF2), Room 4A22, 9500 Gilman Drive, MC0063, La Jolla, California 92093. fax: (858) 822-5370.; Department of Medicine, University of California San Diego, La Jolla, and Department of Medicine, VA San Diego Healthcare System, San Diego, CaliforniaThe leaky gut hypothesis links translocating microbial products with the onset and progression of liver disease, and for a long time they were considered one of its major contributors. However, a more detailed picture of the intestinal microbiota contributing to liver disease started to evolve. The gut is colonized by trillions of microbes that aid in digestion, modulate immune response, and generate a variety of products that result from microbial metabolic activities. These products together with host-bacteria interactions influence both normal physiology and disease susceptibility. A disruption of the symbiosis between microbiota and host is known as dysbiosis and can have profound effects on health. Qualitative changes such as increased proportions of harmful bacteria and reduced levels of beneficial bacteria, and also quantitative changes in the total amount of bacteria (overgrowth) have been associated with liver disease. Understanding the link between the pathophysiology of liver diseases and compositional and functional changes of the microbiota will help in the design of innovative therapies. In this review, we focus on factors resulting in dysbiosis, and discuss how dysbiosis can disrupt intestinal homeostasis and contribute to liver disease. Keywords: Dysbiosis, Leaky Gut, Alcoholic Liver Disease, NASH, NAFLD, Cirrhosis, Microbiome, PAMPshttp://www.sciencedirect.com/science/article/pii/S2352345X15000648 |
| spellingShingle | Cristina Llorente Bernd Schnabl The Gut Microbiota and Liver DiseaseSummary Cellular and Molecular Gastroenterology and Hepatology |
| title | The Gut Microbiota and Liver DiseaseSummary |
| title_full | The Gut Microbiota and Liver DiseaseSummary |
| title_fullStr | The Gut Microbiota and Liver DiseaseSummary |
| title_full_unstemmed | The Gut Microbiota and Liver DiseaseSummary |
| title_short | The Gut Microbiota and Liver DiseaseSummary |
| title_sort | gut microbiota and liver diseasesummary |
| url | http://www.sciencedirect.com/science/article/pii/S2352345X15000648 |
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