An unresolved issue: The relationship between spot urine protein-to-creatinine ratio and 24-hour proteinuria
Objective To investigate the relationship between spot urine protein-to-creatinine (sP/Cr) ratio and 24-h protein excretion in patients with different diagnoses. Methods This retrospective study analysed data from the medical records of patients admitted for24-h proteinuria determination who also ha...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-03-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060518819602 |
| _version_ | 1819292146181603328 |
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| author | Davut Akin Sehmus Ozmen |
| author_facet | Davut Akin Sehmus Ozmen |
| author_sort | Davut Akin |
| collection | DOAJ |
| description | Objective To investigate the relationship between spot urine protein-to-creatinine (sP/Cr) ratio and 24-h protein excretion in patients with different diagnoses. Methods This retrospective study analysed data from the medical records of patients admitted for24-h proteinuria determination who also had sP/Cr ratio data for the same day. Results A total of 1222 urine samples obtained from 694 adult outpatients were analysed. The mean ± SD age of the patients was 53.6 ± 15.9 years. The mean ± SD 24-h proteinuria and sP/Cr were 1.7 ± 2.4 g/day and 1.8 ± 2.4, respectively. The correlation between the sP/Cr and 24-h protein excretion was high (R 2 = 0.89). The sP/Cr ratio accounted for 72% of the variability in 24-h proteinuria in the entire study population. Areas under the curve for 24-h proteinuria at 0.3 g/day, 1.0 g/day and 3.0 g/day were 0.940, 0.966, and 0.949, respectively. The mean + 2SD limits of agreement were between +2.99 and –2.73 g/day according to the Bland Altman analysis. Conclusion This current study found a clinically unacceptable deviation between 24-h proteinuria and sP/Cr ratio. Therefore, the sP/Cr ratio cannot replace 24-h proteinuria. A new method using spot urine protein and creatinine values that is able to minimize under or over estimation is still warranted. |
| first_indexed | 2024-12-24T03:49:53Z |
| format | Article |
| id | doaj.art-a427d8b5bd254202acf94a78d14880e7 |
| institution | Directory Open Access Journal |
| issn | 0300-0605 1473-2300 |
| language | English |
| last_indexed | 2024-12-24T03:49:53Z |
| publishDate | 2019-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-a427d8b5bd254202acf94a78d14880e72022-12-21T17:16:37ZengSAGE PublishingJournal of International Medical Research0300-06051473-23002019-03-014710.1177/0300060518819602An unresolved issue: The relationship between spot urine protein-to-creatinine ratio and 24-hour proteinuriaDavut AkinSehmus OzmenObjective To investigate the relationship between spot urine protein-to-creatinine (sP/Cr) ratio and 24-h protein excretion in patients with different diagnoses. Methods This retrospective study analysed data from the medical records of patients admitted for24-h proteinuria determination who also had sP/Cr ratio data for the same day. Results A total of 1222 urine samples obtained from 694 adult outpatients were analysed. The mean ± SD age of the patients was 53.6 ± 15.9 years. The mean ± SD 24-h proteinuria and sP/Cr were 1.7 ± 2.4 g/day and 1.8 ± 2.4, respectively. The correlation between the sP/Cr and 24-h protein excretion was high (R 2 = 0.89). The sP/Cr ratio accounted for 72% of the variability in 24-h proteinuria in the entire study population. Areas under the curve for 24-h proteinuria at 0.3 g/day, 1.0 g/day and 3.0 g/day were 0.940, 0.966, and 0.949, respectively. The mean + 2SD limits of agreement were between +2.99 and –2.73 g/day according to the Bland Altman analysis. Conclusion This current study found a clinically unacceptable deviation between 24-h proteinuria and sP/Cr ratio. Therefore, the sP/Cr ratio cannot replace 24-h proteinuria. A new method using spot urine protein and creatinine values that is able to minimize under or over estimation is still warranted.https://doi.org/10.1177/0300060518819602 |
| spellingShingle | Davut Akin Sehmus Ozmen An unresolved issue: The relationship between spot urine protein-to-creatinine ratio and 24-hour proteinuria Journal of International Medical Research |
| title | An unresolved issue: The relationship between spot urine protein-to-creatinine ratio and 24-hour proteinuria |
| title_full | An unresolved issue: The relationship between spot urine protein-to-creatinine ratio and 24-hour proteinuria |
| title_fullStr | An unresolved issue: The relationship between spot urine protein-to-creatinine ratio and 24-hour proteinuria |
| title_full_unstemmed | An unresolved issue: The relationship between spot urine protein-to-creatinine ratio and 24-hour proteinuria |
| title_short | An unresolved issue: The relationship between spot urine protein-to-creatinine ratio and 24-hour proteinuria |
| title_sort | unresolved issue the relationship between spot urine protein to creatinine ratio and 24 hour proteinuria |
| url | https://doi.org/10.1177/0300060518819602 |
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