Linking Inflammation and Cardiorespiratory Variability in Sepsis via Computational Modeling

Linking Inflammation and Cardiorespiratory Variability in Sepsis via Computational Modeling

Sepsis leads to multiple organ failure by engaging catastrophic feedback loops in which stressed tissue evokes an inflammatory response and, in turn, inflammation damages tissue. Manifestations of this maladaptive inflammatory response include cardio-respiratory dysfunction that may be reflected in...

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Bibliographic Details
Main Authors: Thomas E. Dick, Yaruslav eMolkov, Gary eNieman, Yee-Hsee eHsieh, Frank J. Jacono, John eDoyle, Jeremy eScheff, Steven E. Calvano, Ioannis P. Androulakis, Gary eAn, Yoram eVodovotz
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-07-01
Series:Frontiers in Physiology
Subjects:
Inflammation
Sepsis
Heart rate variability
mathematical model
Neural control
breathing pattern variability
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00222/full

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