A glutamine tug-of-war between cancer and immune cells: recent advances in unraveling the ongoing battle
Abstract Glutamine metabolism plays a pivotal role in cancer progression, immune cell function, and the modulation of the tumor microenvironment. Dysregulated glutamine metabolism has been implicated in cancer development and immune responses, supported by mounting evidence. Cancer cells heavily rel...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13046-024-02994-0 |
| _version_ | 1797233202513838080 |
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| author | Bolin Wang Jinli Pei Shengnan Xu Jie Liu Jinming Yu |
| author_facet | Bolin Wang Jinli Pei Shengnan Xu Jie Liu Jinming Yu |
| author_sort | Bolin Wang |
| collection | DOAJ |
| description | Abstract Glutamine metabolism plays a pivotal role in cancer progression, immune cell function, and the modulation of the tumor microenvironment. Dysregulated glutamine metabolism has been implicated in cancer development and immune responses, supported by mounting evidence. Cancer cells heavily rely on glutamine as a critical nutrient for survival and proliferation, while immune cells require glutamine for activation and proliferation during immune reactions. This metabolic competition creates a dynamic tug-of-war between cancer and immune cells. Targeting glutamine transporters and downstream enzymes involved in glutamine metabolism holds significant promise in enhancing anti-tumor immunity. A comprehensive understanding of the intricate molecular mechanisms underlying this interplay is crucial for developing innovative therapeutic approaches that improve anti-tumor immunity and patient outcomes. In this review, we provide a comprehensive overview of recent advances in unraveling the tug-of-war of glutamine metabolism between cancer and immune cells and explore potential applications of basic science discoveries in the clinical setting. Further investigations into the regulation of glutamine metabolism in cancer and immune cells are expected to yield valuable insights, paving the way for future therapeutic interventions. |
| first_indexed | 2024-04-24T16:12:25Z |
| format | Article |
| id | doaj.art-a42b4142fbbc43418dbe495cd1d0a768 |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-04-24T16:12:25Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-a42b4142fbbc43418dbe495cd1d0a7682024-03-31T11:38:30ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662024-03-0143112510.1186/s13046-024-02994-0A glutamine tug-of-war between cancer and immune cells: recent advances in unraveling the ongoing battleBolin Wang0Jinli Pei1Shengnan Xu2Jie Liu3Jinming Yu4Lung Cancer Center, West China Hospital, Sichuan UniversityDepartment of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical SciencesDepartment of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical SciencesDepartment of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical SciencesDepartment of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical SciencesAbstract Glutamine metabolism plays a pivotal role in cancer progression, immune cell function, and the modulation of the tumor microenvironment. Dysregulated glutamine metabolism has been implicated in cancer development and immune responses, supported by mounting evidence. Cancer cells heavily rely on glutamine as a critical nutrient for survival and proliferation, while immune cells require glutamine for activation and proliferation during immune reactions. This metabolic competition creates a dynamic tug-of-war between cancer and immune cells. Targeting glutamine transporters and downstream enzymes involved in glutamine metabolism holds significant promise in enhancing anti-tumor immunity. A comprehensive understanding of the intricate molecular mechanisms underlying this interplay is crucial for developing innovative therapeutic approaches that improve anti-tumor immunity and patient outcomes. In this review, we provide a comprehensive overview of recent advances in unraveling the tug-of-war of glutamine metabolism between cancer and immune cells and explore potential applications of basic science discoveries in the clinical setting. Further investigations into the regulation of glutamine metabolism in cancer and immune cells are expected to yield valuable insights, paving the way for future therapeutic interventions.https://doi.org/10.1186/s13046-024-02994-0Glutamine metabolismCancerImmune cellsTumor microenvironmentTherapeutic strategies |
| spellingShingle | Bolin Wang Jinli Pei Shengnan Xu Jie Liu Jinming Yu A glutamine tug-of-war between cancer and immune cells: recent advances in unraveling the ongoing battle Journal of Experimental & Clinical Cancer Research Glutamine metabolism Cancer Immune cells Tumor microenvironment Therapeutic strategies |
| title | A glutamine tug-of-war between cancer and immune cells: recent advances in unraveling the ongoing battle |
| title_full | A glutamine tug-of-war between cancer and immune cells: recent advances in unraveling the ongoing battle |
| title_fullStr | A glutamine tug-of-war between cancer and immune cells: recent advances in unraveling the ongoing battle |
| title_full_unstemmed | A glutamine tug-of-war between cancer and immune cells: recent advances in unraveling the ongoing battle |
| title_short | A glutamine tug-of-war between cancer and immune cells: recent advances in unraveling the ongoing battle |
| title_sort | glutamine tug of war between cancer and immune cells recent advances in unraveling the ongoing battle |
| topic | Glutamine metabolism Cancer Immune cells Tumor microenvironment Therapeutic strategies |
| url | https://doi.org/10.1186/s13046-024-02994-0 |
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