Incidental prostate cancer: a 10-year review of a tertiary center, Tehran, Iran
Amir-reza Abedi,1 Morteza Fallah-Karkan,2 Farzad Allameh,1 Arash Ranjbar,1 Afshin Shadmehr3 1Urology Department, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Urology Department, Shohada-e-Tajrish Hospital, Laser Application in Medical Sciences Research C...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-01-01
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| Series: | Research and Reports in Urology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/incidental-prostate-cancer-a-10-year-review-of-a-tertiary-center-tehra-peer-reviewed-article-RRU |
| _version_ | 1818925671391428608 |
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| author | Abedi AR Fallah-Karkan M Allameh F Ranjbar A Shadmehr A |
| author_facet | Abedi AR Fallah-Karkan M Allameh F Ranjbar A Shadmehr A |
| author_sort | Abedi AR |
| collection | DOAJ |
| description | Amir-reza Abedi,1 Morteza Fallah-Karkan,2 Farzad Allameh,1 Arash Ranjbar,1 Afshin Shadmehr3 1Urology Department, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Urology Department, Shohada-e-Tajrish Hospital, Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Urology Department, Isfahan University of Medical Sciences, Isfahan, Iran Objective: Incidental prostate cancer (IPCa) is defined as a symptom-free cancer unexpectedly discovered upon microscopic examination of resected tissue. The aim of this study was to report the correlation between some specific clinical criteria in patients incidentally diagnosed with prostate cancer (PCa) during transurethral resection of the prostate (TURP) or open prostatectomy (OP) after clinically suspected benign prostatic hyperplasia.Patients and methods: This was a cross-sectional, retrospective study. Data were collected from Shohada-e-Tajrish Hospital database during November 2006 to October 2016. Four hundred and twenty three men suffering from symptomatic benign prostatic hyperplasia who underwent either TURP or OP that provided a prostate specimen were evaluated. The data analysis was performed using Pearson correlation test and independent t-test using SPSS version 20 software.Results: The mean age of subjects was 68.74±9.87 years old (45–93 years). The mean prostate specific antigen (PSA) level was 21.47±13.44 ng/mL (0.6–47.1 ng/mL). Results showed that 84 patients (19.9%) had PCa (40 patients who underwent TURP [12.6%] and 44 patients who underwent OP [40.7%] groups). Cut-off point of PSA for detecting IPCa was 3.8 ng/mL in our study, and this showed sensitivity, specificity, negative predictive value, and positive predictive value of 26.08%, 100%, 100%, and 29.79%, respectively. Twenty two patients with cancer had a positive family history for PCa; thus, a significant relationship between familial history of PCa and its occurrence was shown (p=0.0001).Conclusion: According to the results of this study, the cut-off point for PSA levels in detecting PCa was 3.8 ng/mL, which is similar to that reported by other studies. Familial history of PCa and PSA levels were two predictors in determining the PCa. Keywords: incidental prostate cancer, transurethral resection of the prostate, open prostatectomy, prostate cancer, Iran |
| first_indexed | 2024-12-20T02:44:56Z |
| format | Article |
| id | doaj.art-a42cef9fe13945779578f6f442a53642 |
| institution | Directory Open Access Journal |
| issn | 2253-2447 |
| language | English |
| last_indexed | 2024-12-20T02:44:56Z |
| publishDate | 2018-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Research and Reports in Urology |
| spelling | doaj.art-a42cef9fe13945779578f6f442a536422022-12-21T19:56:12ZengDove Medical PressResearch and Reports in Urology2253-24472018-01-01Volume 101636290Incidental prostate cancer: a 10-year review of a tertiary center, Tehran, IranAbedi ARFallah-Karkan MAllameh FRanjbar AShadmehr AAmir-reza Abedi,1 Morteza Fallah-Karkan,2 Farzad Allameh,1 Arash Ranjbar,1 Afshin Shadmehr3 1Urology Department, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Urology Department, Shohada-e-Tajrish Hospital, Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Urology Department, Isfahan University of Medical Sciences, Isfahan, Iran Objective: Incidental prostate cancer (IPCa) is defined as a symptom-free cancer unexpectedly discovered upon microscopic examination of resected tissue. The aim of this study was to report the correlation between some specific clinical criteria in patients incidentally diagnosed with prostate cancer (PCa) during transurethral resection of the prostate (TURP) or open prostatectomy (OP) after clinically suspected benign prostatic hyperplasia.Patients and methods: This was a cross-sectional, retrospective study. Data were collected from Shohada-e-Tajrish Hospital database during November 2006 to October 2016. Four hundred and twenty three men suffering from symptomatic benign prostatic hyperplasia who underwent either TURP or OP that provided a prostate specimen were evaluated. The data analysis was performed using Pearson correlation test and independent t-test using SPSS version 20 software.Results: The mean age of subjects was 68.74±9.87 years old (45–93 years). The mean prostate specific antigen (PSA) level was 21.47±13.44 ng/mL (0.6–47.1 ng/mL). Results showed that 84 patients (19.9%) had PCa (40 patients who underwent TURP [12.6%] and 44 patients who underwent OP [40.7%] groups). Cut-off point of PSA for detecting IPCa was 3.8 ng/mL in our study, and this showed sensitivity, specificity, negative predictive value, and positive predictive value of 26.08%, 100%, 100%, and 29.79%, respectively. Twenty two patients with cancer had a positive family history for PCa; thus, a significant relationship between familial history of PCa and its occurrence was shown (p=0.0001).Conclusion: According to the results of this study, the cut-off point for PSA levels in detecting PCa was 3.8 ng/mL, which is similar to that reported by other studies. Familial history of PCa and PSA levels were two predictors in determining the PCa. Keywords: incidental prostate cancer, transurethral resection of the prostate, open prostatectomy, prostate cancer, Iranhttps://www.dovepress.com/incidental-prostate-cancer-a-10-year-review-of-a-tertiary-center-tehra-peer-reviewed-article-RRUIncidental prostate cancertransurethral resection of the prostateopen prostatectomyProstate CancerIran |
| spellingShingle | Abedi AR Fallah-Karkan M Allameh F Ranjbar A Shadmehr A Incidental prostate cancer: a 10-year review of a tertiary center, Tehran, Iran Research and Reports in Urology Incidental prostate cancer transurethral resection of the prostate open prostatectomy Prostate Cancer Iran |
| title | Incidental prostate cancer: a 10-year review of a tertiary center, Tehran, Iran |
| title_full | Incidental prostate cancer: a 10-year review of a tertiary center, Tehran, Iran |
| title_fullStr | Incidental prostate cancer: a 10-year review of a tertiary center, Tehran, Iran |
| title_full_unstemmed | Incidental prostate cancer: a 10-year review of a tertiary center, Tehran, Iran |
| title_short | Incidental prostate cancer: a 10-year review of a tertiary center, Tehran, Iran |
| title_sort | incidental prostate cancer a 10 year review of a tertiary center tehran iran |
| topic | Incidental prostate cancer transurethral resection of the prostate open prostatectomy Prostate Cancer Iran |
| url | https://www.dovepress.com/incidental-prostate-cancer-a-10-year-review-of-a-tertiary-center-tehra-peer-reviewed-article-RRU |
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