When the Embryo Meets the Endometrium: Identifying the Features Required for Successful Embryo Implantation
Evaluation of the optimal number of embryos, their quality, and the precise timing for transfer are critical determinants in reproductive success, although still remaining one of the main challenges in assisted reproduction technologies (ART). Indeed, the success of in vitro fertilization (IVF) trea...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/5/2834 |
| _version_ | 1797264378184073216 |
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| author | Valentina Lacconi Micol Massimiani Ilenia Carriero Claudia Bianco Carlo Ticconi Valentina Pavone Alessandra Alteri Ludovico Muzii Rocco Rago Valerio Pisaturo Luisa Campagnolo |
| author_facet | Valentina Lacconi Micol Massimiani Ilenia Carriero Claudia Bianco Carlo Ticconi Valentina Pavone Alessandra Alteri Ludovico Muzii Rocco Rago Valerio Pisaturo Luisa Campagnolo |
| author_sort | Valentina Lacconi |
| collection | DOAJ |
| description | Evaluation of the optimal number of embryos, their quality, and the precise timing for transfer are critical determinants in reproductive success, although still remaining one of the main challenges in assisted reproduction technologies (ART). Indeed, the success of in vitro fertilization (IVF) treatments relies on a multitude of events and factors involving both the endometrium and the embryo. Despite concerted efforts on both fronts, the overall success rates of IVF techniques continue to range between 25% and 30%. The role of the endometrium in implantation has been recently recognized, leading to the hypothesis that both the “soil” and the “seed” play a central role in a successful pregnancy. In this respect, identification of the molecular signature of endometrial receptivity together with the selection of the best embryo for transfer become crucial in ART. Currently, efforts have been made to develop accurate, predictive, and personalized tests to identify the window of implantation and the best quality embryo. However, the value of these tests is still debated, as conflicting results are reported in the literature. The purpose of this review is to summarize and critically report the available criteria to optimize the success of embryo transfer and to better understand current limitations and potential areas for improvement. |
| first_indexed | 2024-04-25T00:27:57Z |
| format | Article |
| id | doaj.art-a42da3a10ec0490586ac42001284e307 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-25T00:27:57Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a42da3a10ec0490586ac42001284e3072024-03-12T16:46:29ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-02-01255283410.3390/ijms25052834When the Embryo Meets the Endometrium: Identifying the Features Required for Successful Embryo ImplantationValentina Lacconi0Micol Massimiani1Ilenia Carriero2Claudia Bianco3Carlo Ticconi4Valentina Pavone5Alessandra Alteri6Ludovico Muzii7Rocco Rago8Valerio Pisaturo9Luisa Campagnolo10Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, ItalySaint Camillus International University of Health Sciences, Via di Sant’Alessandro 8, 00131 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, ItalyDepartment of Surgical Sciences, Section of Gynaecology and Obstetrics, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, ItalyReproductive Sciences Laboratory, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyObstetrics and Gynaecology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyDepartment of Maternal and Child Health and Urological Sciences, “Sapienza” University of Rome, Policlinico Umberto I, 00161 Rome, ItalyPhysiopathology of Reproduction and Andrology Unit, Sandro Pertini Hospital, Via dei Monti Tiburtini 385/389, 00157 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, “Sapienza” University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, ItalyEvaluation of the optimal number of embryos, their quality, and the precise timing for transfer are critical determinants in reproductive success, although still remaining one of the main challenges in assisted reproduction technologies (ART). Indeed, the success of in vitro fertilization (IVF) treatments relies on a multitude of events and factors involving both the endometrium and the embryo. Despite concerted efforts on both fronts, the overall success rates of IVF techniques continue to range between 25% and 30%. The role of the endometrium in implantation has been recently recognized, leading to the hypothesis that both the “soil” and the “seed” play a central role in a successful pregnancy. In this respect, identification of the molecular signature of endometrial receptivity together with the selection of the best embryo for transfer become crucial in ART. Currently, efforts have been made to develop accurate, predictive, and personalized tests to identify the window of implantation and the best quality embryo. However, the value of these tests is still debated, as conflicting results are reported in the literature. The purpose of this review is to summarize and critically report the available criteria to optimize the success of embryo transfer and to better understand current limitations and potential areas for improvement.https://www.mdpi.com/1422-0067/25/5/2834IVFendometrial receptivityimplantationblastocystembryoART |
| spellingShingle | Valentina Lacconi Micol Massimiani Ilenia Carriero Claudia Bianco Carlo Ticconi Valentina Pavone Alessandra Alteri Ludovico Muzii Rocco Rago Valerio Pisaturo Luisa Campagnolo When the Embryo Meets the Endometrium: Identifying the Features Required for Successful Embryo Implantation International Journal of Molecular Sciences IVF endometrial receptivity implantation blastocyst embryo ART |
| title | When the Embryo Meets the Endometrium: Identifying the Features Required for Successful Embryo Implantation |
| title_full | When the Embryo Meets the Endometrium: Identifying the Features Required for Successful Embryo Implantation |
| title_fullStr | When the Embryo Meets the Endometrium: Identifying the Features Required for Successful Embryo Implantation |
| title_full_unstemmed | When the Embryo Meets the Endometrium: Identifying the Features Required for Successful Embryo Implantation |
| title_short | When the Embryo Meets the Endometrium: Identifying the Features Required for Successful Embryo Implantation |
| title_sort | when the embryo meets the endometrium identifying the features required for successful embryo implantation |
| topic | IVF endometrial receptivity implantation blastocyst embryo ART |
| url | https://www.mdpi.com/1422-0067/25/5/2834 |
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