Photodynamic activity of tetraazachlorin derivate studied in vivo
<p>The results of investigation for photodynamic activity of new tetraazachlorin derivate – tetramethyltribenzotetraazachlorin, synthesized in Research Institute of Organic Intermediates and Dyes. The study was performed on female mice of СВА line. The tumor model was transferred solid ascetic...
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| Format: | Article |
| Language: | Russian |
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Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
2013-01-01
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| Series: | Biomedical Photonics |
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| Online Access: | http://www.pdt-journal.com:80/jour/article/view/12 |
| _version_ | 1818515377076830208 |
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| author | V. I. Ivanova-Radkevich Е. А. Machinskaya |
| author_facet | V. I. Ivanova-Radkevich Е. А. Machinskaya |
| author_sort | V. I. Ivanova-Radkevich |
| collection | DOAJ |
| description | <p>The results of investigation for photodynamic activity of new tetraazachlorin derivate – tetramethyltribenzotetraazachlorin, synthesized in Research Institute of Organic Intermediates and Dyes. The study was performed on female mice of СВА line. The tumor model was transferred solid ascetic sarcoma S-37. The samples of photosensitizer, previously solubilized in 10% aqueou s solution ofCremophor EL, injected to mice intravenously on the 7th day of tumor growth in dose of 1–2 mg/kg. Two hours later the irradiation of sensitized tumor using light emitting diode device in a maximal wavelength of 755 nm (light power density – 50 mW/cm<span><sup>2</sup></span>, maximal total light dose – 300 J/cm<span><sup>2</sup></span>) was performed. The efficacy of photodynamic therapy was assessed by growth inhibition rates in the study group comparing with control group. The study showed that photodynamic therapy with investigated sample in dose of 2 mg/kg and light dose of 300 J/cm<span><sup>2</sup></span> significantly inhibited the tumor growth (inhibition rate of 70–80% within 20 days), indicating prospectivity of subsequent investigations of tetraazachlorin as photosensitizer for photodynamic therapy of malignant tumors.</p><p> </p> |
| first_indexed | 2024-12-11T00:28:07Z |
| format | Article |
| id | doaj.art-a42e1f4e6a5c44fe907d0f3c37aa6305 |
| institution | Directory Open Access Journal |
| issn | 2413-9432 |
| language | Russian |
| last_indexed | 2024-12-11T00:28:07Z |
| publishDate | 2013-01-01 |
| publisher | Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" |
| record_format | Article |
| series | Biomedical Photonics |
| spelling | doaj.art-a42e1f4e6a5c44fe907d0f3c37aa63052022-12-22T01:27:28ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322013-01-0122131812Photodynamic activity of tetraazachlorin derivate studied in vivoV. I. Ivanova-Radkevich0Е. А. Machinskaya1Российский Университет дружбы народов, Москва, Россия; Научно-исследовательский институт органических полупродуктов и красителей, Москва, РоссияНаучно-исследовательский институт органических полупродуктов и красителей, Москва, Россия<p>The results of investigation for photodynamic activity of new tetraazachlorin derivate – tetramethyltribenzotetraazachlorin, synthesized in Research Institute of Organic Intermediates and Dyes. The study was performed on female mice of СВА line. The tumor model was transferred solid ascetic sarcoma S-37. The samples of photosensitizer, previously solubilized in 10% aqueou s solution ofCremophor EL, injected to mice intravenously on the 7th day of tumor growth in dose of 1–2 mg/kg. Two hours later the irradiation of sensitized tumor using light emitting diode device in a maximal wavelength of 755 nm (light power density – 50 mW/cm<span><sup>2</sup></span>, maximal total light dose – 300 J/cm<span><sup>2</sup></span>) was performed. The efficacy of photodynamic therapy was assessed by growth inhibition rates in the study group comparing with control group. The study showed that photodynamic therapy with investigated sample in dose of 2 mg/kg and light dose of 300 J/cm<span><sup>2</sup></span> significantly inhibited the tumor growth (inhibition rate of 70–80% within 20 days), indicating prospectivity of subsequent investigations of tetraazachlorin as photosensitizer for photodynamic therapy of malignant tumors.</p><p> </p>http://www.pdt-journal.com:80/jour/article/view/12фотодинамическая терапияфотодинамическая активностьтетраазахлоринфотосенсибилизаторсаркома S-37 |
| spellingShingle | V. I. Ivanova-Radkevich Е. А. Machinskaya Photodynamic activity of tetraazachlorin derivate studied in vivo Biomedical Photonics фотодинамическая терапия фотодинамическая активность тетраазахлорин фотосенсибилизатор саркома S-37 |
| title | Photodynamic activity of tetraazachlorin derivate studied in vivo |
| title_full | Photodynamic activity of tetraazachlorin derivate studied in vivo |
| title_fullStr | Photodynamic activity of tetraazachlorin derivate studied in vivo |
| title_full_unstemmed | Photodynamic activity of tetraazachlorin derivate studied in vivo |
| title_short | Photodynamic activity of tetraazachlorin derivate studied in vivo |
| title_sort | photodynamic activity of tetraazachlorin derivate studied in vivo |
| topic | фотодинамическая терапия фотодинамическая активность тетраазахлорин фотосенсибилизатор саркома S-37 |
| url | http://www.pdt-journal.com:80/jour/article/view/12 |
| work_keys_str_mv | AT viivanovaradkevich photodynamicactivityoftetraazachlorinderivatestudiedinvivo AT eamachinskaya photodynamicactivityoftetraazachlorinderivatestudiedinvivo |