Vitamin D Level in Patients with Consecutive Acute Coronary Syndrome Is Not Correlated with the Parameters of Platelet Activity

Coronary artery disease continues to be the leading cause of death in developed countries. Elevated mean platelet volume (MPV) is associated with an increased incidence of myocardial infarction (MI) and MI-related mortality. Vitamin D concentrations affect the level and function of platelets, which...

Full description

Bibliographic Details
Main Authors: Ewelina A. Dziedzic, Jakub S. Gąsior, Izabela Sowińska, Marek Dąbrowski, Piotr Jankowski
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Journal of Clinical Medicine
Subjects:
Online Access:https://www.mdpi.com/2077-0383/11/3/707
_version_ 1797486914656272384
author Ewelina A. Dziedzic
Jakub S. Gąsior
Izabela Sowińska
Marek Dąbrowski
Piotr Jankowski
author_facet Ewelina A. Dziedzic
Jakub S. Gąsior
Izabela Sowińska
Marek Dąbrowski
Piotr Jankowski
author_sort Ewelina A. Dziedzic
collection DOAJ
description Coronary artery disease continues to be the leading cause of death in developed countries. Elevated mean platelet volume (MPV) is associated with an increased incidence of myocardial infarction (MI) and MI-related mortality. Vitamin D concentrations affect the level and function of platelets, which are the crucial mediator of atherothrombosis and plaque rupture. The main aim of this study was to examine the relationship of serum 25-hydroxyvitamin D (25(OH)D) levels with the platelet activity in patients with a history of an acute coronary syndrome (ACS). This prospective study recruited 268 patients with a history of MI who underwent coronary angiography due to the suspicion of another ACS. Serum 25(OH)D concentration was determined by electrochemiluminescence. Platelet activity was assessed using the MPV and platelet-large cell ratio (P-LCR) parameters. There was no significant difference in MPV and P-LCR values between patients diagnosed with subsequent MI and patients with chronic coronary syndrome (CCS). A significantly lower level of 25(OH)D was demonstrated in patients who had another MI compared to those with CCS (<i>p</i> < 0.05). No significant correlation of 25(OH)D concentrations with platelet activity parameters values was found. The subgroup of patients with consecutive MI was characterized by significantly lower serum vitamin D levels, but this was not related to the analyzed parameters of platelet activity.
first_indexed 2024-03-09T23:41:08Z
format Article
id doaj.art-a42e849cd47d4f8fa65a7669556d08cc
institution Directory Open Access Journal
issn 2077-0383
language English
last_indexed 2024-03-09T23:41:08Z
publishDate 2022-01-01
publisher MDPI AG
record_format Article
series Journal of Clinical Medicine
spelling doaj.art-a42e849cd47d4f8fa65a7669556d08cc2023-11-23T16:52:44ZengMDPI AGJournal of Clinical Medicine2077-03832022-01-0111370710.3390/jcm11030707Vitamin D Level in Patients with Consecutive Acute Coronary Syndrome Is Not Correlated with the Parameters of Platelet ActivityEwelina A. Dziedzic0Jakub S. Gąsior1Izabela Sowińska2Marek Dąbrowski3Piotr Jankowski4Medical Faculty, Lazarski University in Warsaw, 02-662 Warsaw, PolandDepartment of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, 02-091 Warsaw, PolandMedical Faculty, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Cardiology, Bielanski Hospital, 01-809 Warsaw, PolandDepartment of Internal Medicine and Geriatric Cardiology, Centre of Postgraduate Medical Education, 01-813 Warsaw, PolandCoronary artery disease continues to be the leading cause of death in developed countries. Elevated mean platelet volume (MPV) is associated with an increased incidence of myocardial infarction (MI) and MI-related mortality. Vitamin D concentrations affect the level and function of platelets, which are the crucial mediator of atherothrombosis and plaque rupture. The main aim of this study was to examine the relationship of serum 25-hydroxyvitamin D (25(OH)D) levels with the platelet activity in patients with a history of an acute coronary syndrome (ACS). This prospective study recruited 268 patients with a history of MI who underwent coronary angiography due to the suspicion of another ACS. Serum 25(OH)D concentration was determined by electrochemiluminescence. Platelet activity was assessed using the MPV and platelet-large cell ratio (P-LCR) parameters. There was no significant difference in MPV and P-LCR values between patients diagnosed with subsequent MI and patients with chronic coronary syndrome (CCS). A significantly lower level of 25(OH)D was demonstrated in patients who had another MI compared to those with CCS (<i>p</i> < 0.05). No significant correlation of 25(OH)D concentrations with platelet activity parameters values was found. The subgroup of patients with consecutive MI was characterized by significantly lower serum vitamin D levels, but this was not related to the analyzed parameters of platelet activity.https://www.mdpi.com/2077-0383/11/3/707myocardial infarctionacute coronary syndromevitamin D25-hydroxyvitamin Dplateletsatherothrombosis
spellingShingle Ewelina A. Dziedzic
Jakub S. Gąsior
Izabela Sowińska
Marek Dąbrowski
Piotr Jankowski
Vitamin D Level in Patients with Consecutive Acute Coronary Syndrome Is Not Correlated with the Parameters of Platelet Activity
Journal of Clinical Medicine
myocardial infarction
acute coronary syndrome
vitamin D
25-hydroxyvitamin D
platelets
atherothrombosis
title Vitamin D Level in Patients with Consecutive Acute Coronary Syndrome Is Not Correlated with the Parameters of Platelet Activity
title_full Vitamin D Level in Patients with Consecutive Acute Coronary Syndrome Is Not Correlated with the Parameters of Platelet Activity
title_fullStr Vitamin D Level in Patients with Consecutive Acute Coronary Syndrome Is Not Correlated with the Parameters of Platelet Activity
title_full_unstemmed Vitamin D Level in Patients with Consecutive Acute Coronary Syndrome Is Not Correlated with the Parameters of Platelet Activity
title_short Vitamin D Level in Patients with Consecutive Acute Coronary Syndrome Is Not Correlated with the Parameters of Platelet Activity
title_sort vitamin d level in patients with consecutive acute coronary syndrome is not correlated with the parameters of platelet activity
topic myocardial infarction
acute coronary syndrome
vitamin D
25-hydroxyvitamin D
platelets
atherothrombosis
url https://www.mdpi.com/2077-0383/11/3/707
work_keys_str_mv AT ewelinaadziedzic vitamindlevelinpatientswithconsecutiveacutecoronarysyndromeisnotcorrelatedwiththeparametersofplateletactivity
AT jakubsgasior vitamindlevelinpatientswithconsecutiveacutecoronarysyndromeisnotcorrelatedwiththeparametersofplateletactivity
AT izabelasowinska vitamindlevelinpatientswithconsecutiveacutecoronarysyndromeisnotcorrelatedwiththeparametersofplateletactivity
AT marekdabrowski vitamindlevelinpatientswithconsecutiveacutecoronarysyndromeisnotcorrelatedwiththeparametersofplateletactivity
AT piotrjankowski vitamindlevelinpatientswithconsecutiveacutecoronarysyndromeisnotcorrelatedwiththeparametersofplateletactivity