Seroprevalence of Hantavirus in Forestry Workers, Northern France, 2019–2020
We aimed to estimate the seroprevalence of <i>Puumala orthohantavirus</i> (PUUV) among forestry workers in northern France, and to explore sociodemographic risk factors. We conducted a random cross-sectional seroprevalence survey among 1777 forestry workers in 2019–2020. The presence of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/2/338 |
| _version_ | 1797617803042226176 |
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| author | Catarina Krug Emma Rigaud Dieyenaba Siby-Diakite Laetitia Bénézet Pavlos Papadopoulos Henriette de Valk Gaëtan Deffontaines Alexandra Septfons Jean-Marc Reynes |
| author_facet | Catarina Krug Emma Rigaud Dieyenaba Siby-Diakite Laetitia Bénézet Pavlos Papadopoulos Henriette de Valk Gaëtan Deffontaines Alexandra Septfons Jean-Marc Reynes |
| author_sort | Catarina Krug |
| collection | DOAJ |
| description | We aimed to estimate the seroprevalence of <i>Puumala orthohantavirus</i> (PUUV) among forestry workers in northern France, and to explore sociodemographic risk factors. We conducted a random cross-sectional seroprevalence survey among 1777 forestry workers in 2019–2020. The presence of immunoglobulin G against PUUV antigens in serum was assessed using enzyme-linked immunosorbent assay and confirmed using immunofluorescence assay. Poisson regression models were used to explore factors associated with seropositivity. Weighted seroprevalence was 5% (3–6) in northeastern France, 4% (2–6) in north central France, and 1% in two regions located in the center of the country (Auvergne and Limousin). There were no seropositive workers detected in northwestern France. Seropositivity was associated with age, sex, and cumulative seniority in the forestry sector. Seroprevalence was highest in known endemic areas of the northeast and lowest in the northwest. Nevertheless, we found serological evidence of PUUV infection in two regions located in the center of the country, suggesting circulation of the virus in these regions, previously thought to be non-endemic. |
| first_indexed | 2024-03-11T08:00:58Z |
| format | Article |
| id | doaj.art-a42fb2734d2d4592b164d419bf556589 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T08:00:58Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-a42fb2734d2d4592b164d419bf5565892023-11-16T23:47:44ZengMDPI AGViruses1999-49152023-01-0115233810.3390/v15020338Seroprevalence of Hantavirus in Forestry Workers, Northern France, 2019–2020Catarina Krug0Emma Rigaud1Dieyenaba Siby-Diakite2Laetitia Bénézet3Pavlos Papadopoulos4Henriette de Valk5Gaëtan Deffontaines6Alexandra Septfons7Jean-Marc Reynes8Santé Publique France, 94410 Saint-Maurice, FranceCaisse Centrale de la Mutualité Sociale Agricole, 93000 Bobigny, FranceInstitut Pasteur, Université Paris Cité, 75015 Paris, FranceSanté Publique France, 94410 Saint-Maurice, FranceInstitut Pasteur, Université Paris Cité, 75015 Paris, FranceSanté Publique France, 94410 Saint-Maurice, FranceCaisse Centrale de la Mutualité Sociale Agricole, 93000 Bobigny, FranceSanté Publique France, 94410 Saint-Maurice, FranceInstitut Pasteur, Université Paris Cité, 75015 Paris, FranceWe aimed to estimate the seroprevalence of <i>Puumala orthohantavirus</i> (PUUV) among forestry workers in northern France, and to explore sociodemographic risk factors. We conducted a random cross-sectional seroprevalence survey among 1777 forestry workers in 2019–2020. The presence of immunoglobulin G against PUUV antigens in serum was assessed using enzyme-linked immunosorbent assay and confirmed using immunofluorescence assay. Poisson regression models were used to explore factors associated with seropositivity. Weighted seroprevalence was 5% (3–6) in northeastern France, 4% (2–6) in north central France, and 1% in two regions located in the center of the country (Auvergne and Limousin). There were no seropositive workers detected in northwestern France. Seropositivity was associated with age, sex, and cumulative seniority in the forestry sector. Seroprevalence was highest in known endemic areas of the northeast and lowest in the northwest. Nevertheless, we found serological evidence of PUUV infection in two regions located in the center of the country, suggesting circulation of the virus in these regions, previously thought to be non-endemic.https://www.mdpi.com/1999-4915/15/2/338Franceseroepidemiologic studiesoccupational exposuresHantavirusPuumala virus |
| spellingShingle | Catarina Krug Emma Rigaud Dieyenaba Siby-Diakite Laetitia Bénézet Pavlos Papadopoulos Henriette de Valk Gaëtan Deffontaines Alexandra Septfons Jean-Marc Reynes Seroprevalence of Hantavirus in Forestry Workers, Northern France, 2019–2020 Viruses France seroepidemiologic studies occupational exposures Hantavirus Puumala virus |
| title | Seroprevalence of Hantavirus in Forestry Workers, Northern France, 2019–2020 |
| title_full | Seroprevalence of Hantavirus in Forestry Workers, Northern France, 2019–2020 |
| title_fullStr | Seroprevalence of Hantavirus in Forestry Workers, Northern France, 2019–2020 |
| title_full_unstemmed | Seroprevalence of Hantavirus in Forestry Workers, Northern France, 2019–2020 |
| title_short | Seroprevalence of Hantavirus in Forestry Workers, Northern France, 2019–2020 |
| title_sort | seroprevalence of hantavirus in forestry workers northern france 2019 2020 |
| topic | France seroepidemiologic studies occupational exposures Hantavirus Puumala virus |
| url | https://www.mdpi.com/1999-4915/15/2/338 |
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