Recent Advances in the Development of Biosensors for Malaria Diagnosis
The impact of malaria on global health has continually prompted the need to develop more effective diagnostic strategies that could overcome deficiencies in accurate and early detection. In this review, we examine the various biosensor-based methods for malaria diagnostic biomarkers, namely; <i&g...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/20/3/799 |
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| author | Francis D. Krampa Yaw Aniweh Prosper Kanyong Gordon A. Awandare |
| author_facet | Francis D. Krampa Yaw Aniweh Prosper Kanyong Gordon A. Awandare |
| author_sort | Francis D. Krampa |
| collection | DOAJ |
| description | The impact of malaria on global health has continually prompted the need to develop more effective diagnostic strategies that could overcome deficiencies in accurate and early detection. In this review, we examine the various biosensor-based methods for malaria diagnostic biomarkers, namely; <i>Plasmodium falciparum</i> histidine-rich protein 2 (PfHRP-2), parasite lactate dehydrogenase (pLDH), aldolase, glutamate dehydrogenase (GDH), and the biocrystal hemozoin. The models that demonstrate a potential for field application have been discussed, looking at the fabrication and analytical performance characteristics, including (but not exclusively limited to): response time, sensitivity, detection limit, linear range, and storage stability, which are first summarized in a tabular form and then described in detail. The conclusion summarizes the state-of-the-art technologies applied in the field, the current challenges and the emerging prospects for malaria biosensors. |
| first_indexed | 2024-04-13T06:46:48Z |
| format | Article |
| id | doaj.art-a4305efe36e24223b7392cbb95bf1b2d |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-13T06:46:48Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-a4305efe36e24223b7392cbb95bf1b2d2022-12-22T02:57:33ZengMDPI AGSensors1424-82202020-02-0120379910.3390/s20030799s20030799Recent Advances in the Development of Biosensors for Malaria DiagnosisFrancis D. Krampa0Yaw Aniweh1Prosper Kanyong2Gordon A. Awandare3West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, P.O. Box LG 25, Legon, Accra, GhanaWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, P.O. Box LG 25, Legon, Accra, GhanaWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, P.O. Box LG 25, Legon, Accra, GhanaWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, P.O. Box LG 25, Legon, Accra, GhanaThe impact of malaria on global health has continually prompted the need to develop more effective diagnostic strategies that could overcome deficiencies in accurate and early detection. In this review, we examine the various biosensor-based methods for malaria diagnostic biomarkers, namely; <i>Plasmodium falciparum</i> histidine-rich protein 2 (PfHRP-2), parasite lactate dehydrogenase (pLDH), aldolase, glutamate dehydrogenase (GDH), and the biocrystal hemozoin. The models that demonstrate a potential for field application have been discussed, looking at the fabrication and analytical performance characteristics, including (but not exclusively limited to): response time, sensitivity, detection limit, linear range, and storage stability, which are first summarized in a tabular form and then described in detail. The conclusion summarizes the state-of-the-art technologies applied in the field, the current challenges and the emerging prospects for malaria biosensors.https://www.mdpi.com/1424-8220/20/3/799malaria biomarkersbiosensorsclinical diagnosismedical devicesbiosensing |
| spellingShingle | Francis D. Krampa Yaw Aniweh Prosper Kanyong Gordon A. Awandare Recent Advances in the Development of Biosensors for Malaria Diagnosis Sensors malaria biomarkers biosensors clinical diagnosis medical devices biosensing |
| title | Recent Advances in the Development of Biosensors for Malaria Diagnosis |
| title_full | Recent Advances in the Development of Biosensors for Malaria Diagnosis |
| title_fullStr | Recent Advances in the Development of Biosensors for Malaria Diagnosis |
| title_full_unstemmed | Recent Advances in the Development of Biosensors for Malaria Diagnosis |
| title_short | Recent Advances in the Development of Biosensors for Malaria Diagnosis |
| title_sort | recent advances in the development of biosensors for malaria diagnosis |
| topic | malaria biomarkers biosensors clinical diagnosis medical devices biosensing |
| url | https://www.mdpi.com/1424-8220/20/3/799 |
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