Vitamin D<sub>3</sub> Supplementation: Comparison of 1000 IU and 2000 IU Dose in Healthy Individuals
Background: Scientific studies point to a significant global vitamin D deficiency. The recommended dose of vitamin D for the adult population in Central Europe is 800–2000 IU/day. The aim of our study was to determine whether doses of 1000 IU or 2000 IU of vitamin D<sub>3</sub> are adequ...
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MDPI AG
2023-03-01
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| author | Eva Dědečková Roman Viták Michal Jirásko Markéta Králová Ondřej Topolčan Ladislav Pecen Tomáš Fürst Pavel Brož Radek Kučera |
| author_facet | Eva Dědečková Roman Viták Michal Jirásko Markéta Králová Ondřej Topolčan Ladislav Pecen Tomáš Fürst Pavel Brož Radek Kučera |
| author_sort | Eva Dědečková |
| collection | DOAJ |
| description | Background: Scientific studies point to a significant global vitamin D deficiency. The recommended dose of vitamin D for the adult population in Central Europe is 800–2000 IU/day. The aim of our study was to determine whether doses of 1000 IU or 2000 IU of vitamin D<sub>3</sub> are adequate to achieve the sufficiency reference values of [25(OH)D]. Methods: Seventy-two healthy volunteers, average age twenty-two, took part in the study. The study was conducted from October to March in order to eliminate intra-dermal vitamin D production. Vitamin D<sub>3</sub> in an oleaginous mixture was used. The participants used either 1000 IU or 2000 IU/daily for two 60-day periods with a 30-day break. Results: The dose of 1000 IU, taken for 60 days, increased vitamin D levels relatively little. Furthermore, serum vitamin D levels decreased in the 30 days following the cessation of supplementation. Taking 2000 IU daily led to a sharp increase in serum levels which plateaued 30 days after the subjects stopped using vitamin D<sub>3</sub> drops. Conclusions: Both doses, taken daily, can help maintain adequate vitamin D levels during the winter months. A daily dose of 2000 IU, however, maintained the desired levels of vitamin D for a longer period. |
| first_indexed | 2024-03-11T06:17:28Z |
| format | Article |
| id | doaj.art-a43243f4e0c84250b391932715662013 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T06:17:28Z |
| publishDate | 2023-03-01 |
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| record_format | Article |
| series | Life |
| spelling | doaj.art-a43243f4e0c84250b3919327156620132023-11-17T12:12:39ZengMDPI AGLife2075-17292023-03-0113380810.3390/life13030808Vitamin D<sub>3</sub> Supplementation: Comparison of 1000 IU and 2000 IU Dose in Healthy IndividualsEva Dědečková0Roman Viták1Michal Jirásko2Markéta Králová3Ondřej Topolčan4Ladislav Pecen5Tomáš Fürst6Pavel Brož7Radek Kučera8Department of Pharmacology and Toxicology, Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech RepublicDepartment of Pharmacology and Toxicology, Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech RepublicDepartment of Pharmacology and Toxicology, Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech RepublicDepartment of Pharmacology and Toxicology, Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech RepublicDepartment of Immunochemistry, University Hospital and Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech RepublicDepartment of Immunochemistry, University Hospital and Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech RepublicFaculty of Science, Palacky University in Olomouc, 779 00 Olomouc, Czech RepublicDepartment of Clinical Biochemistry and Hematology, University Hospital and Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech RepublicDepartment of Pharmacology and Toxicology, Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech RepublicBackground: Scientific studies point to a significant global vitamin D deficiency. The recommended dose of vitamin D for the adult population in Central Europe is 800–2000 IU/day. The aim of our study was to determine whether doses of 1000 IU or 2000 IU of vitamin D<sub>3</sub> are adequate to achieve the sufficiency reference values of [25(OH)D]. Methods: Seventy-two healthy volunteers, average age twenty-two, took part in the study. The study was conducted from October to March in order to eliminate intra-dermal vitamin D production. Vitamin D<sub>3</sub> in an oleaginous mixture was used. The participants used either 1000 IU or 2000 IU/daily for two 60-day periods with a 30-day break. Results: The dose of 1000 IU, taken for 60 days, increased vitamin D levels relatively little. Furthermore, serum vitamin D levels decreased in the 30 days following the cessation of supplementation. Taking 2000 IU daily led to a sharp increase in serum levels which plateaued 30 days after the subjects stopped using vitamin D<sub>3</sub> drops. Conclusions: Both doses, taken daily, can help maintain adequate vitamin D levels during the winter months. A daily dose of 2000 IU, however, maintained the desired levels of vitamin D for a longer period.https://www.mdpi.com/2075-1729/13/3/808vitamin Dvitamin D deficiencyvitamin D insufficiencysupplementationserum level |
| spellingShingle | Eva Dědečková Roman Viták Michal Jirásko Markéta Králová Ondřej Topolčan Ladislav Pecen Tomáš Fürst Pavel Brož Radek Kučera Vitamin D<sub>3</sub> Supplementation: Comparison of 1000 IU and 2000 IU Dose in Healthy Individuals Life vitamin D vitamin D deficiency vitamin D insufficiency supplementation serum level |
| title | Vitamin D<sub>3</sub> Supplementation: Comparison of 1000 IU and 2000 IU Dose in Healthy Individuals |
| title_full | Vitamin D<sub>3</sub> Supplementation: Comparison of 1000 IU and 2000 IU Dose in Healthy Individuals |
| title_fullStr | Vitamin D<sub>3</sub> Supplementation: Comparison of 1000 IU and 2000 IU Dose in Healthy Individuals |
| title_full_unstemmed | Vitamin D<sub>3</sub> Supplementation: Comparison of 1000 IU and 2000 IU Dose in Healthy Individuals |
| title_short | Vitamin D<sub>3</sub> Supplementation: Comparison of 1000 IU and 2000 IU Dose in Healthy Individuals |
| title_sort | vitamin d sub 3 sub supplementation comparison of 1000 iu and 2000 iu dose in healthy individuals |
| topic | vitamin D vitamin D deficiency vitamin D insufficiency supplementation serum level |
| url | https://www.mdpi.com/2075-1729/13/3/808 |
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