Hepatitis B Related Liver Cirrhosis in Oman
Objectives: An estimated 887 000 deaths were due to chronic hepatitis B (CHB) related complications in 2015 worldwide. Most of these deaths were related to decompensated liver cirrhosis and hepatocellular carcinoma (HCC). Oman is a country with an intermediate prevalence of CHB. The Hepatitis B vacc...
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| Format: | Article |
| Language: | English |
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Oman Medical Specialty Board
2022-05-01
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| Series: | Oman Medical Journal |
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| Online Access: | https://omjournal.org/articleDetails.aspx?coType=1&aId=3147 |
| _version_ | 1818550082869395456 |
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| author | Khalid Al-Naamani Rahma Al-Harthi Said A. Al-Busafi Haifa Al Zuhaibi Siham Al-Sinani Heba Omer Wasif Rasool |
| author_facet | Khalid Al-Naamani Rahma Al-Harthi Said A. Al-Busafi Haifa Al Zuhaibi Siham Al-Sinani Heba Omer Wasif Rasool |
| author_sort | Khalid Al-Naamani |
| collection | DOAJ |
| description | Objectives: An estimated 887 000 deaths were due to chronic hepatitis B (CHB) related complications in 2015 worldwide. Most of these deaths were related to decompensated liver cirrhosis and hepatocellular carcinoma (HCC). Oman is a country with an intermediate prevalence of CHB. The Hepatitis B vaccine was introduced in Oman in 1990, with a vaccine coverage rate of > 95% reported in 2005. Despite the association between CHB and liver cirrhosis and HCC, no available data from Oman demonstrates CHB-related liver cirrhosis. We sought to estimate the prevalence of CHB among patients with liver cirrhosis from Oman. Methods: We conducted a retrospective chart review of patients diagnosed with liver cirrhosis at Sultan Qaboos University Hospital and Armed Forces Hospital between January 2006 and April 2013. All pediatric and adult patients with liver cirrhosis were included. We collected demographic data and liver cirrhosis investigations. Results: A total of 419 patients were included. Two-thirds of the patients were males. The median age was 59 years. Omani patients represented the majority (97.1%) of patients with cirrhosis. Diabetes mellitus was present in almost half of the patients, and 22.2% indicated alcohol consumption. Evidence of previous or current hepatitis B virus (HBV) infection was found in about half of the cohort (51.3%). Only 3.3% of CHB patients were positive for hepatitis B viral protein. HBV DNA was detected in 47 patients (21.9%), of which 20 patients had a high viral load > 2000 IU/ml. More than a third (36.7%) had positive hepatitis B surface antibody (anti-HBs), indicating immunity to HBV, and 27.1% was due to previous HBV infection, 5.2% was immune due to vaccination, and 3.7% had positive anti-HBs and unknown anti-HBc status. Negative anti-HBs was found in 34.1% of the cohort and 29.9% had unknown immunity status. HBV coinfection with HCV was found in 24.7% of HBV patients with cirrhosis. Conclusions: Serological markers of CHB are common among liver cirrhosis patients in Oman. CHB related cirrhosis was more common in old age males than females (70.7% vs. 29.3%, respectively; p < 0.010). Evidence of past or present HBV infection was found in > 50% of the patients. |
| first_indexed | 2024-12-12T08:41:42Z |
| format | Article |
| id | doaj.art-a433350ec9db44b98341a6772500c318 |
| institution | Directory Open Access Journal |
| issn | 1999-768X 2070-5204 |
| language | English |
| last_indexed | 2024-12-12T08:41:42Z |
| publishDate | 2022-05-01 |
| publisher | Oman Medical Specialty Board |
| record_format | Article |
| series | Oman Medical Journal |
| spelling | doaj.art-a433350ec9db44b98341a6772500c3182022-12-22T00:30:46ZengOman Medical Specialty BoardOman Medical Journal1999-768X2070-52042022-05-01373e384e38410.5001/omj.2022.54Hepatitis B Related Liver Cirrhosis in OmanKhalid Al-Naamani0Rahma Al-Harthi1Said A. Al-Busafi2Haifa Al Zuhaibi3Siham Al-Sinani4Heba Omer5Wasif Rasool6Department of Internal Medicine, Division of Gastroenterology and Hepatology, Armed Forces Hospital, Muscat, OmanProfessional Competence Affairs, Oman Medical Specialty Board, Muscat, OmanDepartment of Medicine, Division of Gastroenterology, Sultan Qaboos University Hospital, Muscat, OmanDepartment of Medicine, Division of Gastroenterology, Sultan Qaboos University Hospital, Muscat, OmanProfessional Competence Affairs, Oman Medical Specialty Board, Muscat, OmanEndemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Giza, EgyptDepartment of Medicine, Division of Gastroenterology, Sultan Qaboos University Hospital, Muscat, OmanObjectives: An estimated 887 000 deaths were due to chronic hepatitis B (CHB) related complications in 2015 worldwide. Most of these deaths were related to decompensated liver cirrhosis and hepatocellular carcinoma (HCC). Oman is a country with an intermediate prevalence of CHB. The Hepatitis B vaccine was introduced in Oman in 1990, with a vaccine coverage rate of > 95% reported in 2005. Despite the association between CHB and liver cirrhosis and HCC, no available data from Oman demonstrates CHB-related liver cirrhosis. We sought to estimate the prevalence of CHB among patients with liver cirrhosis from Oman. Methods: We conducted a retrospective chart review of patients diagnosed with liver cirrhosis at Sultan Qaboos University Hospital and Armed Forces Hospital between January 2006 and April 2013. All pediatric and adult patients with liver cirrhosis were included. We collected demographic data and liver cirrhosis investigations. Results: A total of 419 patients were included. Two-thirds of the patients were males. The median age was 59 years. Omani patients represented the majority (97.1%) of patients with cirrhosis. Diabetes mellitus was present in almost half of the patients, and 22.2% indicated alcohol consumption. Evidence of previous or current hepatitis B virus (HBV) infection was found in about half of the cohort (51.3%). Only 3.3% of CHB patients were positive for hepatitis B viral protein. HBV DNA was detected in 47 patients (21.9%), of which 20 patients had a high viral load > 2000 IU/ml. More than a third (36.7%) had positive hepatitis B surface antibody (anti-HBs), indicating immunity to HBV, and 27.1% was due to previous HBV infection, 5.2% was immune due to vaccination, and 3.7% had positive anti-HBs and unknown anti-HBc status. Negative anti-HBs was found in 34.1% of the cohort and 29.9% had unknown immunity status. HBV coinfection with HCV was found in 24.7% of HBV patients with cirrhosis. Conclusions: Serological markers of CHB are common among liver cirrhosis patients in Oman. CHB related cirrhosis was more common in old age males than females (70.7% vs. 29.3%, respectively; p < 0.010). Evidence of past or present HBV infection was found in > 50% of the patients.https://omjournal.org/articleDetails.aspx?coType=1&aId=3147hepatitis b virushepatitis bchronicliver cirrhosisoman |
| spellingShingle | Khalid Al-Naamani Rahma Al-Harthi Said A. Al-Busafi Haifa Al Zuhaibi Siham Al-Sinani Heba Omer Wasif Rasool Hepatitis B Related Liver Cirrhosis in Oman Oman Medical Journal hepatitis b virus hepatitis b chronic liver cirrhosis oman |
| title | Hepatitis B Related Liver Cirrhosis in Oman |
| title_full | Hepatitis B Related Liver Cirrhosis in Oman |
| title_fullStr | Hepatitis B Related Liver Cirrhosis in Oman |
| title_full_unstemmed | Hepatitis B Related Liver Cirrhosis in Oman |
| title_short | Hepatitis B Related Liver Cirrhosis in Oman |
| title_sort | hepatitis b related liver cirrhosis in oman |
| topic | hepatitis b virus hepatitis b chronic liver cirrhosis oman |
| url | https://omjournal.org/articleDetails.aspx?coType=1&aId=3147 |
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