Design, synthesis, and anticancer activity of novel 4,6-dimorpholinyl-1,3,5-triazine compounds
The chalcone structure was introduced into the 4,6-dimorpholinyl-1,3,5-triazine molecule through the C-N bond, and a series of new compounds were obtained. Among them, the pyridyl-containing 6o exhibits anti-proliferation activity similar to that of cisplatin on SW620. Interestingly, the phenyl-cont...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2023-06-01
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| Series: | Heterocyclic Communications |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/hc-2022-0152 |
| _version_ | 1797743802822164480 |
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| author | Li Jinjing Li Linbo Liu Yuxiao Zhang Jie Shi Chengyang Zhou Shujing Qiu Hongbin |
| author_facet | Li Jinjing Li Linbo Liu Yuxiao Zhang Jie Shi Chengyang Zhou Shujing Qiu Hongbin |
| author_sort | Li Jinjing |
| collection | DOAJ |
| description | The chalcone structure was introduced into the 4,6-dimorpholinyl-1,3,5-triazine molecule through the C-N bond, and a series of new compounds were obtained. Among them, the pyridyl-containing 6o exhibits anti-proliferation activity similar to that of cisplatin on SW620. Interestingly, the phenyl-containing 6a exhibits a certain selectivity for the anti-proliferation activity of SW620. |
| first_indexed | 2024-03-12T15:00:42Z |
| format | Article |
| id | doaj.art-a4336f0d34eb47478d787580abcdae7f |
| institution | Directory Open Access Journal |
| issn | 2191-0197 |
| language | English |
| last_indexed | 2024-03-12T15:00:42Z |
| publishDate | 2023-06-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Heterocyclic Communications |
| spelling | doaj.art-a4336f0d34eb47478d787580abcdae7f2023-08-14T07:06:12ZengDe GruyterHeterocyclic Communications2191-01972023-06-01291673610.1515/hc-2022-0152Design, synthesis, and anticancer activity of novel 4,6-dimorpholinyl-1,3,5-triazine compoundsLi Jinjing0Li Linbo1Liu Yuxiao2Zhang Jie3Shi Chengyang4Zhou Shujing5Qiu Hongbin6College of Pharmacy, Jiamusi University, Jiamusi, 154007, ChinaCollege of Pharmacy, Jiamusi University, Jiamusi, 154007, ChinaCollege of Pharmacy, Jiamusi University, Jiamusi, 154007, ChinaCollege of Pharmacy, Jiamusi University, Jiamusi, 154007, ChinaCollege of Pharmacy, Jiamusi University, Jiamusi, 154007, ChinaInstitute of Pharmacy in Heilongjiang Province, Jiamusi, 154007, ChinaJiamusi University, Jiamusi, 154007, ChinaThe chalcone structure was introduced into the 4,6-dimorpholinyl-1,3,5-triazine molecule through the C-N bond, and a series of new compounds were obtained. Among them, the pyridyl-containing 6o exhibits anti-proliferation activity similar to that of cisplatin on SW620. Interestingly, the phenyl-containing 6a exhibits a certain selectivity for the anti-proliferation activity of SW620.https://doi.org/10.1515/hc-2022-0152chalcones4,6-dimorpholinyl-1,3,5-triazineanticancer activity |
| spellingShingle | Li Jinjing Li Linbo Liu Yuxiao Zhang Jie Shi Chengyang Zhou Shujing Qiu Hongbin Design, synthesis, and anticancer activity of novel 4,6-dimorpholinyl-1,3,5-triazine compounds Heterocyclic Communications chalcones 4,6-dimorpholinyl-1,3,5-triazine anticancer activity |
| title | Design, synthesis, and anticancer activity of novel 4,6-dimorpholinyl-1,3,5-triazine compounds |
| title_full | Design, synthesis, and anticancer activity of novel 4,6-dimorpholinyl-1,3,5-triazine compounds |
| title_fullStr | Design, synthesis, and anticancer activity of novel 4,6-dimorpholinyl-1,3,5-triazine compounds |
| title_full_unstemmed | Design, synthesis, and anticancer activity of novel 4,6-dimorpholinyl-1,3,5-triazine compounds |
| title_short | Design, synthesis, and anticancer activity of novel 4,6-dimorpholinyl-1,3,5-triazine compounds |
| title_sort | design synthesis and anticancer activity of novel 4 6 dimorpholinyl 1 3 5 triazine compounds |
| topic | chalcones 4,6-dimorpholinyl-1,3,5-triazine anticancer activity |
| url | https://doi.org/10.1515/hc-2022-0152 |
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