Stable thyroid function despite regular use of povidone-iodine throat spray for SARS-CoV-2 prophylaxis
Background It is unclear whether unintentional ingestion of povidone-iodine following its application to the oropharyngeal space could affect thyroid function.Objective To examine thyroid function among individuals who regularly apply povidone-iodine throat spray for SARS-CoV-2 prophylaxis.Methods W...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Annals of Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2022.2108132 |
| _version_ | 1811219799647191040 |
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| author | Amy May Lin Quek Mei Yen Ng Ooiean Teng Nicole-Ann Lim Geelyn Jeng Lin Ng Samantha Peiling Yang Mikael Hartman Paul Anantharajah Tambyah Alex R. Cook Raymond Chee Seong Seet |
| author_facet | Amy May Lin Quek Mei Yen Ng Ooiean Teng Nicole-Ann Lim Geelyn Jeng Lin Ng Samantha Peiling Yang Mikael Hartman Paul Anantharajah Tambyah Alex R. Cook Raymond Chee Seong Seet |
| author_sort | Amy May Lin Quek |
| collection | DOAJ |
| description | Background It is unclear whether unintentional ingestion of povidone-iodine following its application to the oropharyngeal space could affect thyroid function.Objective To examine thyroid function among individuals who regularly apply povidone-iodine throat spray for SARS-CoV-2 prophylaxis.Methods We designed a case-control study to compare thyroid function among participants who received povidone-iodine throat spray three times a day for 42 days (‘cases’) and those who received vitamin C (‘controls’). Thyroid function was assessed by profiling serum TSH, free T3, and free T4; iodine status was estimated using serum thyroglobulin level, while infection status was determined by measuring anti-SARS-CoV-2 antibody against the nucleocapsid antigen. All measurements were performed in pairs, at baseline and 42 days later. Pre-post changes in thyroid function were compared between groups, before and after stratification according to baseline TSH quartiles.Results A total of 177 men (117 cases and 60 controls) (mean age, 32.2 years) were included. Despite comparable demographics and clinical profiles, no clinically or statistically significant differences were observed in thyroid indices between ‘cases’ and ‘controls’ before and after stratification according to TSH quartiles. None of the participants developed symptomatic hypo- or hyperthyroidism throughout the study. Post-hoc analysis did not reveal differences in thyroid function according to infection status.Conclusions Data from this study support the overall safety of povidone-iodine use in the oropharyngeal space for SARS-CoV-2 prophylaxis among individuals with normal thyroid function and subclinical thyroid disease. |
| first_indexed | 2024-04-12T07:31:26Z |
| format | Article |
| id | doaj.art-a434cbc161764494b3b0337a1ea30715 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-04-12T07:31:26Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-a434cbc161764494b3b0337a1ea307152022-12-22T03:42:03ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602022-12-015413299330510.1080/07853890.2022.2108132Stable thyroid function despite regular use of povidone-iodine throat spray for SARS-CoV-2 prophylaxisAmy May Lin Quek0Mei Yen Ng1Ooiean Teng2Nicole-Ann Lim3Geelyn Jeng Lin Ng4Samantha Peiling Yang5Mikael Hartman6Paul Anantharajah Tambyah7Alex R. Cook8Raymond Chee Seong Seet9Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeBackground It is unclear whether unintentional ingestion of povidone-iodine following its application to the oropharyngeal space could affect thyroid function.Objective To examine thyroid function among individuals who regularly apply povidone-iodine throat spray for SARS-CoV-2 prophylaxis.Methods We designed a case-control study to compare thyroid function among participants who received povidone-iodine throat spray three times a day for 42 days (‘cases’) and those who received vitamin C (‘controls’). Thyroid function was assessed by profiling serum TSH, free T3, and free T4; iodine status was estimated using serum thyroglobulin level, while infection status was determined by measuring anti-SARS-CoV-2 antibody against the nucleocapsid antigen. All measurements were performed in pairs, at baseline and 42 days later. Pre-post changes in thyroid function were compared between groups, before and after stratification according to baseline TSH quartiles.Results A total of 177 men (117 cases and 60 controls) (mean age, 32.2 years) were included. Despite comparable demographics and clinical profiles, no clinically or statistically significant differences were observed in thyroid indices between ‘cases’ and ‘controls’ before and after stratification according to TSH quartiles. None of the participants developed symptomatic hypo- or hyperthyroidism throughout the study. Post-hoc analysis did not reveal differences in thyroid function according to infection status.Conclusions Data from this study support the overall safety of povidone-iodine use in the oropharyngeal space for SARS-CoV-2 prophylaxis among individuals with normal thyroid function and subclinical thyroid disease.https://www.tandfonline.com/doi/10.1080/07853890.2022.2108132Povidone-iodineSARS-CoV-2thyroid function |
| spellingShingle | Amy May Lin Quek Mei Yen Ng Ooiean Teng Nicole-Ann Lim Geelyn Jeng Lin Ng Samantha Peiling Yang Mikael Hartman Paul Anantharajah Tambyah Alex R. Cook Raymond Chee Seong Seet Stable thyroid function despite regular use of povidone-iodine throat spray for SARS-CoV-2 prophylaxis Annals of Medicine Povidone-iodine SARS-CoV-2 thyroid function |
| title | Stable thyroid function despite regular use of povidone-iodine throat spray for SARS-CoV-2 prophylaxis |
| title_full | Stable thyroid function despite regular use of povidone-iodine throat spray for SARS-CoV-2 prophylaxis |
| title_fullStr | Stable thyroid function despite regular use of povidone-iodine throat spray for SARS-CoV-2 prophylaxis |
| title_full_unstemmed | Stable thyroid function despite regular use of povidone-iodine throat spray for SARS-CoV-2 prophylaxis |
| title_short | Stable thyroid function despite regular use of povidone-iodine throat spray for SARS-CoV-2 prophylaxis |
| title_sort | stable thyroid function despite regular use of povidone iodine throat spray for sars cov 2 prophylaxis |
| topic | Povidone-iodine SARS-CoV-2 thyroid function |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2022.2108132 |
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