Single Shot vs. Cocktail: A Comparison of Mono- and Combinative Application of miRNA-Targeted Mesyl Oligonucleotides for Efficient Antitumor Therapy

Single Shot vs. Cocktail: A Comparison of Mono- and Combinative Application of miRNA-Targeted Mesyl Oligonucleotides for Efficient Antitumor Therapy

Rational combinations of sequence-specific inhibitors of pro-oncogenic miRNAs can efficiently interfere with specific tumor survival pathways, offering great promise for targeted therapy of oncological diseases. Herein, we uncovered the potential of multicomponent therapy by double or triple combina...

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Bibliographic Details
Main Authors: Svetlana Gaponova, Olga Patutina, Aleksandra Sen’kova, Ekaterina Burakova, Innokenty Savin, Andrey Markov, Elena Shmendel, Mikhail Maslov, Dmitry Stetsenko, Valentin Vlassov, Marina Zenkova
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cancers
Subjects:
antisense oligonucleotide
mesyl phosphoramidate
oligonucleotide cocktail
anti-miRNA therapy
oncogenic microRNA
lymphosarcoma
Online Access:https://www.mdpi.com/2072-6694/14/18/4396

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