A Novel Synthetic Dihydroindeno[1,2-b] Indole Derivative (LS-2-3j) Reverses ABCB1- and ABCG2-Mediated Multidrug Resistance in Cancer Cells

A Novel Synthetic Dihydroindeno[1,2-b] Indole Derivative (LS-2-3j) Reverses ABCB1- and ABCG2-Mediated Multidrug Resistance in Cancer Cells

10-oxo-5-(3-(pyrrolidin-1-yl) propyl)-5,10-dihydroindeno [1,2-b] indol-9-yl propionate (LS-2-3j) is a new chemically synthesized indole compound and some related analogues are known to be inhibitors (such as alectinib and Ko143) of ATP-binding cassette (ABC) transporters, especially the ABC transpor...

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Bibliographic Details
Main Authors: Chao Guo, Fangyuan Liu, Jie Qi, Jiahui Ma, Shiqi Lin, Caiyun Zhang, Qian Zhang, Hangyu Zhang, Rong Lu, Xia Li
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Molecules
Subjects:
indole derivative
multidrug resistance
K562/A02 cell line
MCF-7/ABCG2 cell line
ABCB1
ABCG2
Online Access:https://www.mdpi.com/1420-3049/23/12/3264

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