Low handgrip strength is associated with worse functional outcomes in long COVID
Abstract The diagnosis of long COVID is troublesome, even when functional limitations are present. Dynapenia is the loss of muscle strength and power production that is not caused by neurologic or muscular diseases, being mostly associated with changes in neurologic function and/or the intrinsic for...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-52401-z |
| _version_ | 1797276561599102976 |
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| author | Camila Miriam Suemi Sato Barros do Amaral Cássia da Luz Goulart Bernardo Maia da Silva Jefferson Valente Anna Gabriela Rezende Eduardo Fernandes Nadia Cubas-Vega Mayla Gabriela Silva Borba Vanderson Sampaio Wuelton Monteiro Gisely Cardoso de Melo Marcus Lacerda Guilherme Peixoto Tinoco Arêas Fernando Almeida-Val |
| author_facet | Camila Miriam Suemi Sato Barros do Amaral Cássia da Luz Goulart Bernardo Maia da Silva Jefferson Valente Anna Gabriela Rezende Eduardo Fernandes Nadia Cubas-Vega Mayla Gabriela Silva Borba Vanderson Sampaio Wuelton Monteiro Gisely Cardoso de Melo Marcus Lacerda Guilherme Peixoto Tinoco Arêas Fernando Almeida-Val |
| author_sort | Camila Miriam Suemi Sato Barros do Amaral |
| collection | DOAJ |
| description | Abstract The diagnosis of long COVID is troublesome, even when functional limitations are present. Dynapenia is the loss of muscle strength and power production that is not caused by neurologic or muscular diseases, being mostly associated with changes in neurologic function and/or the intrinsic force-generating properties of skeletal muscle, which altogether, may partially explain the limitations seen in long COVID. This study aimed to identify the distribution and possible associations of dynapenia with functional assessments in patients with long COVID. A total of 113 patients with COVID-19 were evaluated by functional assessment 120 days post-acute severe disease. Body composition, respiratory muscle strength, spirometry, six-minute walk test (6MWT, meters), and hand-grip strength (HGS, Kilogram-force) were assessed. Dynapenia was defined as HGS < 30 Kgf (men), and < 20 Kgf (women). Twenty-five (22%) participants were dynapenic, presenting lower muscle mass (p < 0.001), worse forced expiratory volume in the first second (FEV1) (p = 0.0001), lower forced vital capacity (p < 0.001), and inspiratory (p = 0.007) and expiratory (p = 0.002) peek pressures, as well as worse 6MWT performance (p < 0.001). Dynapenia, independently of age, was associated with worse FEV1, maximal expiratory pressure (MEP), and 6MWT, (p < 0.001) outcomes. Patients with dynapenia had higher intensive care unit (ICU) admission rates (p = 0.01) and need for invasive mechanical ventilation (p = 0.007) during hospitalization. The HGS is a simple, reliable, and low-cost measurement that can be performed in outpatient clinics in low- and middle-income countries. Thus, HGS may be used as a proxy indicator of functional impairment in this population. |
| first_indexed | 2024-03-07T15:29:56Z |
| format | Article |
| id | doaj.art-a436f9d85482467292fb4bb097f37c07 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:29:56Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a436f9d85482467292fb4bb097f37c072024-03-05T16:30:04ZengNature PortfolioScientific Reports2045-23222024-01-011411910.1038/s41598-024-52401-zLow handgrip strength is associated with worse functional outcomes in long COVIDCamila Miriam Suemi Sato Barros do Amaral0Cássia da Luz Goulart1Bernardo Maia da Silva2Jefferson Valente3Anna Gabriela Rezende4Eduardo Fernandes5Nadia Cubas-Vega6Mayla Gabriela Silva Borba7Vanderson Sampaio8Wuelton Monteiro9Gisely Cardoso de Melo10Marcus Lacerda11Guilherme Peixoto Tinoco Arêas12Fernando Almeida-Val13Fundação de Medicina Tropical Dr Heitor Vieira DouradoFundação de Medicina Tropical Dr Heitor Vieira DouradoFundação de Medicina Tropical Dr Heitor Vieira DouradoFundação de Medicina Tropical Dr Heitor Vieira DouradoUniversidade Federal do AmazonasUniversidade do Estado Do AmazonasUniversidad Nacional Autónoma de HondurasUniversidade do Estado Do AmazonasInstituto Todos Pela SaúdeFundação de Medicina Tropical Dr Heitor Vieira DouradoFundação de Medicina Tropical Dr Heitor Vieira DouradoFundação de Medicina Tropical Dr Heitor Vieira DouradoUniversidade Federal do AmazonasFundação de Medicina Tropical Dr Heitor Vieira DouradoAbstract The diagnosis of long COVID is troublesome, even when functional limitations are present. Dynapenia is the loss of muscle strength and power production that is not caused by neurologic or muscular diseases, being mostly associated with changes in neurologic function and/or the intrinsic force-generating properties of skeletal muscle, which altogether, may partially explain the limitations seen in long COVID. This study aimed to identify the distribution and possible associations of dynapenia with functional assessments in patients with long COVID. A total of 113 patients with COVID-19 were evaluated by functional assessment 120 days post-acute severe disease. Body composition, respiratory muscle strength, spirometry, six-minute walk test (6MWT, meters), and hand-grip strength (HGS, Kilogram-force) were assessed. Dynapenia was defined as HGS < 30 Kgf (men), and < 20 Kgf (women). Twenty-five (22%) participants were dynapenic, presenting lower muscle mass (p < 0.001), worse forced expiratory volume in the first second (FEV1) (p = 0.0001), lower forced vital capacity (p < 0.001), and inspiratory (p = 0.007) and expiratory (p = 0.002) peek pressures, as well as worse 6MWT performance (p < 0.001). Dynapenia, independently of age, was associated with worse FEV1, maximal expiratory pressure (MEP), and 6MWT, (p < 0.001) outcomes. Patients with dynapenia had higher intensive care unit (ICU) admission rates (p = 0.01) and need for invasive mechanical ventilation (p = 0.007) during hospitalization. The HGS is a simple, reliable, and low-cost measurement that can be performed in outpatient clinics in low- and middle-income countries. Thus, HGS may be used as a proxy indicator of functional impairment in this population.https://doi.org/10.1038/s41598-024-52401-z |
| spellingShingle | Camila Miriam Suemi Sato Barros do Amaral Cássia da Luz Goulart Bernardo Maia da Silva Jefferson Valente Anna Gabriela Rezende Eduardo Fernandes Nadia Cubas-Vega Mayla Gabriela Silva Borba Vanderson Sampaio Wuelton Monteiro Gisely Cardoso de Melo Marcus Lacerda Guilherme Peixoto Tinoco Arêas Fernando Almeida-Val Low handgrip strength is associated with worse functional outcomes in long COVID Scientific Reports |
| title | Low handgrip strength is associated with worse functional outcomes in long COVID |
| title_full | Low handgrip strength is associated with worse functional outcomes in long COVID |
| title_fullStr | Low handgrip strength is associated with worse functional outcomes in long COVID |
| title_full_unstemmed | Low handgrip strength is associated with worse functional outcomes in long COVID |
| title_short | Low handgrip strength is associated with worse functional outcomes in long COVID |
| title_sort | low handgrip strength is associated with worse functional outcomes in long covid |
| url | https://doi.org/10.1038/s41598-024-52401-z |
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