Dysfunctional Glucose Metabolism in Alzheimer’s Disease Onset and Potential Pharmacological Interventions
Alzheimer’s disease (AD) is the most common age-related dementia. The alteration in metabolic characteristics determines the prognosis. Patients at risk show reduced glucose uptake in the brain. Additionally, type 2 diabetes mellitus increases the risk of AD with increasing age. Therefore, changes i...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/17/9540 |
| _version_ | 1797495335931609088 |
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| author | Vijay Kumar So-Hyeon Kim Kausik Bishayee |
| author_facet | Vijay Kumar So-Hyeon Kim Kausik Bishayee |
| author_sort | Vijay Kumar |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is the most common age-related dementia. The alteration in metabolic characteristics determines the prognosis. Patients at risk show reduced glucose uptake in the brain. Additionally, type 2 diabetes mellitus increases the risk of AD with increasing age. Therefore, changes in glucose uptake in the cerebral cortex may predict the histopathological diagnosis of AD. The shifts in glucose uptake and metabolism, insulin resistance, oxidative stress, and abnormal autophagy advance the pathogenesis of AD syndrome. Here, we summarize the role of altered glucose metabolism in type 2 diabetes for AD prognosis. Additionally, we discuss diagnosis and potential pharmacological interventions for glucose metabolism defects in AD to encourage the development of novel therapeutic methods. |
| first_indexed | 2024-03-10T01:47:21Z |
| format | Article |
| id | doaj.art-a437314a63bb449481bd37c4fcbd4947 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:47:21Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a437314a63bb449481bd37c4fcbd49472023-11-23T13:12:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012317954010.3390/ijms23179540Dysfunctional Glucose Metabolism in Alzheimer’s Disease Onset and Potential Pharmacological InterventionsVijay Kumar0So-Hyeon Kim1Kausik Bishayee2Department of Biochemistry, Institute of Cell Differentiation and Aging, College of Medicine, Hallym University, Chuncheon 24252, KoreaBiomedical Science Core-Facility, Soonchunhyang Institute of Medi-Bio Science, Soonchunhyang University, Cheonan 31151, KoreaBiomedical Science Core-Facility, Soonchunhyang Institute of Medi-Bio Science, Soonchunhyang University, Cheonan 31151, KoreaAlzheimer’s disease (AD) is the most common age-related dementia. The alteration in metabolic characteristics determines the prognosis. Patients at risk show reduced glucose uptake in the brain. Additionally, type 2 diabetes mellitus increases the risk of AD with increasing age. Therefore, changes in glucose uptake in the cerebral cortex may predict the histopathological diagnosis of AD. The shifts in glucose uptake and metabolism, insulin resistance, oxidative stress, and abnormal autophagy advance the pathogenesis of AD syndrome. Here, we summarize the role of altered glucose metabolism in type 2 diabetes for AD prognosis. Additionally, we discuss diagnosis and potential pharmacological interventions for glucose metabolism defects in AD to encourage the development of novel therapeutic methods.https://www.mdpi.com/1422-0067/23/17/9540Alzheimer’s diseasediabetesglycolysisROSgenetic mutationtherapy |
| spellingShingle | Vijay Kumar So-Hyeon Kim Kausik Bishayee Dysfunctional Glucose Metabolism in Alzheimer’s Disease Onset and Potential Pharmacological Interventions International Journal of Molecular Sciences Alzheimer’s disease diabetes glycolysis ROS genetic mutation therapy |
| title | Dysfunctional Glucose Metabolism in Alzheimer’s Disease Onset and Potential Pharmacological Interventions |
| title_full | Dysfunctional Glucose Metabolism in Alzheimer’s Disease Onset and Potential Pharmacological Interventions |
| title_fullStr | Dysfunctional Glucose Metabolism in Alzheimer’s Disease Onset and Potential Pharmacological Interventions |
| title_full_unstemmed | Dysfunctional Glucose Metabolism in Alzheimer’s Disease Onset and Potential Pharmacological Interventions |
| title_short | Dysfunctional Glucose Metabolism in Alzheimer’s Disease Onset and Potential Pharmacological Interventions |
| title_sort | dysfunctional glucose metabolism in alzheimer s disease onset and potential pharmacological interventions |
| topic | Alzheimer’s disease diabetes glycolysis ROS genetic mutation therapy |
| url | https://www.mdpi.com/1422-0067/23/17/9540 |
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