Circulating Lymphocyte Subsets Induce Secondary Infection in Acute Pancreatitis
Acute pancreatitis (AP) is considered a cascade of immune responses triggered by acinar cell necrosis. AP involves two main processes of systemic inflammatory response syndrome and subsequent compensatory anti-inflammatory response syndrome. Although great efforts have been made regarding AP therapy...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-03-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcimb.2020.00128/full |
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| author | Lili Ding Yimin Yang Hongxiang Li Haijiao Wang Pujun Gao |
| author_facet | Lili Ding Yimin Yang Hongxiang Li Haijiao Wang Pujun Gao |
| author_sort | Lili Ding |
| collection | DOAJ |
| description | Acute pancreatitis (AP) is considered a cascade of immune responses triggered by acinar cell necrosis. AP involves two main processes of systemic inflammatory response syndrome and subsequent compensatory anti-inflammatory response syndrome. Although great efforts have been made regarding AP therapy, the mortality rate of AP remains high. Secondary infection acts a lethal factor in AP. Lymphocytes act as major immune mediators in immune responses in the course of this disease. However, the relationship between lymphocytes and secondary infection in AP is unclear. This review summarizes the variation of lymphocytes and infection in AP. Knowledge of the characterization of circulating lymphocyte abnormalities is relevant for understanding the pathophysiology of AP. |
| first_indexed | 2024-12-24T13:06:58Z |
| format | Article |
| id | doaj.art-a438338b3e68455eaff3c05eb0be2fd6 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-24T13:06:58Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-a438338b3e68455eaff3c05eb0be2fd62022-12-21T16:53:58ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882020-03-011010.3389/fcimb.2020.00128504379Circulating Lymphocyte Subsets Induce Secondary Infection in Acute PancreatitisLili Ding0Yimin Yang1Hongxiang Li2Haijiao Wang3Pujun Gao4Department of Intensive Care Unit, The First Hospital of Jilin University, Changchun, ChinaDepartment of Intensive Care Unit, The First Hospital of Jilin University, Changchun, ChinaDepartment of Intensive Care Unit, The First Hospital of Jilin University, Changchun, ChinaDepartment of Gynecology Oncology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Hepatology, The First Hospital of Jilin University, Jilin University, Changchun, ChinaAcute pancreatitis (AP) is considered a cascade of immune responses triggered by acinar cell necrosis. AP involves two main processes of systemic inflammatory response syndrome and subsequent compensatory anti-inflammatory response syndrome. Although great efforts have been made regarding AP therapy, the mortality rate of AP remains high. Secondary infection acts a lethal factor in AP. Lymphocytes act as major immune mediators in immune responses in the course of this disease. However, the relationship between lymphocytes and secondary infection in AP is unclear. This review summarizes the variation of lymphocytes and infection in AP. Knowledge of the characterization of circulating lymphocyte abnormalities is relevant for understanding the pathophysiology of AP.https://www.frontiersin.org/article/10.3389/fcimb.2020.00128/fullacute pancreatitislymphocytelymphopeniaimmunosuppressionsecondary infection |
| spellingShingle | Lili Ding Yimin Yang Hongxiang Li Haijiao Wang Pujun Gao Circulating Lymphocyte Subsets Induce Secondary Infection in Acute Pancreatitis Frontiers in Cellular and Infection Microbiology acute pancreatitis lymphocyte lymphopenia immunosuppression secondary infection |
| title | Circulating Lymphocyte Subsets Induce Secondary Infection in Acute Pancreatitis |
| title_full | Circulating Lymphocyte Subsets Induce Secondary Infection in Acute Pancreatitis |
| title_fullStr | Circulating Lymphocyte Subsets Induce Secondary Infection in Acute Pancreatitis |
| title_full_unstemmed | Circulating Lymphocyte Subsets Induce Secondary Infection in Acute Pancreatitis |
| title_short | Circulating Lymphocyte Subsets Induce Secondary Infection in Acute Pancreatitis |
| title_sort | circulating lymphocyte subsets induce secondary infection in acute pancreatitis |
| topic | acute pancreatitis lymphocyte lymphopenia immunosuppression secondary infection |
| url | https://www.frontiersin.org/article/10.3389/fcimb.2020.00128/full |
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