Shotgun proteomics of extracellular matrix in late senescent human dermal fibroblasts reveals a down-regulated fibronectin-centered network

Shotgun proteomics of extracellular matrix in late senescent human dermal fibroblasts reveals a down-regulated fibronectin-centered network

Abstract Extracellular matrix (ECM) proteins play a pivotal role in cell growth and differentiation. To characterize aged ECM proteins, we compared the proteomes by shotgun method of young (passage #15) and late senescent (passage #40) human dermal fibroblasts (HDFs) using SDS-PAGE coupled with LC–M...

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Bibliographic Details
Main Authors:	Kun Cho, Kyeong Eun Yang, Soo-Bin Nam, Song-I. Lee, Eui-Ju Yeo, Jong-Soon Choi
Format:	Article
Language:	English
Published:	SpringerOpen 2022-06-01
Series:	Journal of Analytical Science and Technology
Subjects:	Extracellular matrix Human dermal fibroblasts Late senescence Shotgun proteomics Protein network analysis
Online Access:	https://doi.org/10.1186/s40543-022-00329-2

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