Refining Stereotaxic Neurosurgery Techniques and Welfare Assessment for Long-Term Intracerebroventricular Device Implantation in Rodents

Refining Stereotaxic Neurosurgery Techniques and Welfare Assessment for Long-Term Intracerebroventricular Device Implantation in Rodents

Stereotaxic surgeries enable precise access to specific brain regions, being of particular interest for chronic intracerebroventricular drug delivery. However, the challenge of long-term studies at this level is to allow the implantation of drug storage devices and their correct intrathecal connecti...

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Bibliographic Details
Main Authors: Ester Pérez-Martín, Almudena Coto-Vilcapoma, Juan Castilla-Silgado, María Rodríguez-Cañón, Catuxa Prado, Gabriel Álvarez, Marco Antonio Álvarez-Vega, Benjamín Fernández-García, Manuel Menéndez-González, Cristina Tomás-Zapico
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Animals
Subjects:
3Rs
animal research
animal welfare
cannula fixation
intrathecal implantation
preclinical neurosurgery
Online Access:https://www.mdpi.com/2076-2615/13/16/2627

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