Alteration in TET1 as potential biomarker for immune checkpoint blockade in multiple cancers

Alteration in TET1 as potential biomarker for immune checkpoint blockade in multiple cancers

Abstract Background Immune checkpoint inhibitors (ICIs) have achieved impressive success in different cancer types, yet responses vary and predictive biomarkers are urgently needed. Growing evidence points to a link between DNA methylation and anti-tumor immunity, while clinical data on the associat...

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Bibliographic Details
Main Authors: Hao-Xiang Wu, Yan-Xing Chen, Zi-Xian Wang, Qi Zhao, Ming-Ming He, Ying-Nan Wang, Feng Wang, Rui-Hua Xu
Format: Article
Language:English
Published: BMJ Publishing Group 2019-10-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Biomarker
DNA methylation
Immune checkpoint blockade
Pan-cancer
TET1
Online Access:http://link.springer.com/article/10.1186/s40425-019-0737-3

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