Behavioral and electrophysiological aspects of cognition in neonate rats lactated by morphine addicted mothers
<em><strong>Objective(s):</strong></em> In addition to genetic factors, environmental phenomena during postnatal age highly affect development and, in turn, function of the brain. The present work evaluates if morphine consumption during lactation period influences the spatia...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2019-09-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/article_13434_6a007a5d774d407c77ea631868f81343.pdf |
| _version_ | 1811265331233030144 |
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| author | Fatemeh Aghighi Mojgan Mohammadifar Hamidreza Banafshe Mahmoud Salami Sayyed Alireza Talaei |
| author_facet | Fatemeh Aghighi Mojgan Mohammadifar Hamidreza Banafshe Mahmoud Salami Sayyed Alireza Talaei |
| author_sort | Fatemeh Aghighi |
| collection | DOAJ |
| description | <em><strong>Objective(s):</strong></em> In addition to genetic factors, environmental phenomena during postnatal age highly affect development and, in turn, function of the brain. The present work evaluates if morphine consumption during lactation period influences the spatial performances and synaptic plasticity in rats at neonatal period of age. <br /><em><strong>Materials and Methods:</strong> </em>Three groups of mothers were subcutaneously administered by 5 (M5), 10 (M10) or 20 (M20) mg/kg morphine every 12 hours during the lactation period. At 45 days old, their offspring were introduced to Morris water maze for assessment of spatial learning and memory. Basic field excitatory post-synaptic potentials (fEPSPs) were recorded in the CA1 area of hippocampus and, then, long term potentiation (LTP) was induced by tetanic stimulation. <br /><em><strong>Results:</strong></em> We found that the M10 and M20 rats spent more time and traveled longer distance to find the hidden platform of maze when compared to the control animals (P<em><strong>Conclusion:</strong></em> The present study provides behavioral and electrophysiological proofs for negative effect of morphine on the hippocampal-related function in the neonatally morphine-exposed rats. |
| first_indexed | 2024-04-12T20:21:43Z |
| format | Article |
| id | doaj.art-a439d3d6ad1e45eca3b58166b171c710 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-04-12T20:21:43Z |
| publishDate | 2019-09-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-a439d3d6ad1e45eca3b58166b171c7102022-12-22T03:17:59ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742019-09-012291059106410.22038/ijbms.2019.36892.878913434Behavioral and electrophysiological aspects of cognition in neonate rats lactated by morphine addicted mothersFatemeh Aghighi0Mojgan Mohammadifar1Hamidreza Banafshe2Mahmoud Salami3Sayyed Alireza Talaei4Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, IranPhysiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, IranPhysiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, IranPhysiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, IranPhysiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran<em><strong>Objective(s):</strong></em> In addition to genetic factors, environmental phenomena during postnatal age highly affect development and, in turn, function of the brain. The present work evaluates if morphine consumption during lactation period influences the spatial performances and synaptic plasticity in rats at neonatal period of age. <br /><em><strong>Materials and Methods:</strong> </em>Three groups of mothers were subcutaneously administered by 5 (M5), 10 (M10) or 20 (M20) mg/kg morphine every 12 hours during the lactation period. At 45 days old, their offspring were introduced to Morris water maze for assessment of spatial learning and memory. Basic field excitatory post-synaptic potentials (fEPSPs) were recorded in the CA1 area of hippocampus and, then, long term potentiation (LTP) was induced by tetanic stimulation. <br /><em><strong>Results:</strong></em> We found that the M10 and M20 rats spent more time and traveled longer distance to find the hidden platform of maze when compared to the control animals (P<em><strong>Conclusion:</strong></em> The present study provides behavioral and electrophysiological proofs for negative effect of morphine on the hippocampal-related function in the neonatally morphine-exposed rats.http://ijbms.mums.ac.ir/article_13434_6a007a5d774d407c77ea631868f81343.pdfHippocampusLactationMaze learningMorphineRatsSpatial MemorySynaptic plasticity |
| spellingShingle | Fatemeh Aghighi Mojgan Mohammadifar Hamidreza Banafshe Mahmoud Salami Sayyed Alireza Talaei Behavioral and electrophysiological aspects of cognition in neonate rats lactated by morphine addicted mothers Iranian Journal of Basic Medical Sciences Hippocampus Lactation Maze learning Morphine Rats Spatial Memory Synaptic plasticity |
| title | Behavioral and electrophysiological aspects of cognition in neonate rats lactated by morphine addicted mothers |
| title_full | Behavioral and electrophysiological aspects of cognition in neonate rats lactated by morphine addicted mothers |
| title_fullStr | Behavioral and electrophysiological aspects of cognition in neonate rats lactated by morphine addicted mothers |
| title_full_unstemmed | Behavioral and electrophysiological aspects of cognition in neonate rats lactated by morphine addicted mothers |
| title_short | Behavioral and electrophysiological aspects of cognition in neonate rats lactated by morphine addicted mothers |
| title_sort | behavioral and electrophysiological aspects of cognition in neonate rats lactated by morphine addicted mothers |
| topic | Hippocampus Lactation Maze learning Morphine Rats Spatial Memory Synaptic plasticity |
| url | http://ijbms.mums.ac.ir/article_13434_6a007a5d774d407c77ea631868f81343.pdf |
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