Neutralizing Ability of a Single Domain VNAR Antibody: In Vitro Neutralization of SARS-CoV-2 Variants of Concern

Neutralizing Ability of a Single Domain VNAR Antibody: In Vitro Neutralization of SARS-CoV-2 Variants of Concern

Severe Acute Respiratory Syndrome Coronavirus 2 is the causal pathogen of coronavirus disease 2019 (COVID-19). The emergence of new variants with different mutational patterns has limited the therapeutic options available and complicated the development of effective neutralizing antibodies targeting...

Full description

Bibliographic Details
Main Authors:	Blanca J. Valdovino-Navarro, Salvador Dueñas, G. Isaí Flores-Acosta, Jahaziel Gasperin-Bulbarela, Johanna Bernaldez-Sarabia, Olivia Cabanillas-Bernal, Karla E. Cervantes-Luevano, Alexei F. Licea-Navarro
Format:	Article
Language:	English
Published:	MDPI AG 2022-10-01
Series:	International Journal of Molecular Sciences
Subjects:	COVID-19 neutralizing antibody SARS-CoV-2 single-domain antibody spike protein VNAR therapy
Online Access:	https://www.mdpi.com/1422-0067/23/20/12267

Similar Items

Unleashing the power of shark variable single domains (VNARs): broadly neutralizing tools for combating SARS-CoV-2
by: Olivia Cabanillas-Bernal, et al.
Published: (2023-09-01)

Identification and characterization of IgNAR and VNAR repertoire from the ocellate spot skate (Okamejei kenojei)
by: Jianqing Wen, et al.
Published: (2023-05-01)

COVID-19 Neutralizing Antibodies in Breast Milk of Mothers Vaccinated with Three Different Vaccines in Mexico
by: Olivia Cabanillas-Bernal, et al.
Published: (2022-04-01)

Chimeric Peptides from <i>Californiconus californicus</i> and <i>Heterodontus francisci</i> with Antigen-Binding Capacity: A Conotoxin Scaffold to Create Non-Natural Antibodies (NoNaBodies)
by: Salvador Dueñas, et al.
Published: (2023-04-01)

Intraocular Penetration of a vNAR: In Vivo and In Vitro VEGF165 Neutralization
by: Tanya A. Camacho-Villegas, et al.
Published: (2018-03-01)

Identification of Anti-TNFα VNAR Single Domain Antibodies from Whitespotted Bambooshark (<i>Chiloscyllium plagiosum</i>)
by: Linfei Zhao, et al.
Published: (2022-04-01)

Identification and characterization of shark VNARs targeting the Helicobacter pylori adhesin HpaA
by: Yanchun Gao, et al.
Published: (2023-12-01)

Screening and Characterization of Shark-Derived VNARs against SARS-CoV-2 Spike RBD Protein
by: Yu-Lei Chen, et al.
Published: (2022-09-01)

vNARs as Neutralizing Intracellular Therapeutic Agents: Glioblastoma as a Target
by: Alejandro Manzanares-Guzmán, et al.
Published: (2024-03-01)

Brain Delivery of Single-Domain Antibodies: A Focus on VHH and VNAR
by: Elodie Pothin, et al.
Published: (2020-09-01)

Evaluation of variable new antigen receptors (vNARs) as a novel cathepsin S (CTSS) targeting strategy
by: P. Smyth, et al.
Published: (2023-12-01)

Preparation of pH-sensitive nanogels bioconjugated with shark antibodies (VNAR) for targeted drug delivery with potential applications in colon cancer therapies.
by: Lizbeth A Manzanares-Guevara, et al.
Published: (2024-01-01)

Preparation of pH-sensitive nanogels bioconjugated with shark antibodies (VNAR) for targeted drug delivery with potential applications in colon cancer therapies
by: Lizbeth A. Manzanares-Guevara, et al.
Published: (2024-01-01)

VNAR development through antigen immunization of Japanese topeshark (Hemitriakis japanica)
by: Hiroyuki Takeda, et al.
Published: (2023-09-01)

The influence of antibody humanization on shark variable domain (VNAR) binding site ensembles
by: Monica L. Fernández-Quintero, et al.
Published: (2022-09-01)

First pan-specific vNAR against human TGF-β as a potential therapeutic application: in silico modeling assessment
by: Mirna Burciaga-Flores, et al.
Published: (2023-03-01)

Isolation and Characterization of Targeting-HBsAg VNAR Single Domain Antibodies from Whitespotted Bamboo Sharks (<i>Chiloscyllium plagiosum</i>)
by: Xierui Jiang, et al.
Published: (2023-04-01)

Shark IgNAR: The Next Broad Application Antibody in Clinical Diagnoses and Tumor Therapies?
by: Xiaofeng Jiang, et al.
Published: (2023-09-01)

Single Domain Antibodies as New Biomarker Detectors
by: Chiuan Herng Leow, et al.
Published: (2017-10-01)

A New Neutralization Epitope in the Spike Protein of Porcine Epidemic Diarrhea Virus
by: Jianbo Liu, et al.
Published: (2022-08-01)

Detection of SARS-CoV-2 Nucleocapsid, Spike, and Neutralizing Antibodies in Vaccinated Japanese
by: Rie Midorikawa, et al.
Published: (2022-05-01)

Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2
by: Wael Bahnan, et al.
Published: (2022-01-01)

Transportation of Single-Domain Antibodies through the Blood–Brain Barrier
by: Eduardo Ruiz-López, et al.
Published: (2021-07-01)

SARS-CoV-2 spike S2-specific neutralizing antibodies
by: Chia-Jung Li, et al.
Published: (2023-12-01)

A Structural Update of Neutralizing Epitopes on the HIV Envelope, a Moving Target
by: Emma Parker Miller, et al.
Published: (2021-09-01)

Kinetics of Nucleocapsid, Spike and Neutralizing Antibodies, and Viral Load in Patients with Severe COVID-19 Treated with Convalescent Plasma
by: Thomas P. Thomopoulos, et al.
Published: (2021-09-01)

Systematical assessment of the impact of single spike mutations of SARS-CoV-2 Omicron sub-variants on the neutralization capacity of post-vaccination sera
by: Maeva Katzmarzyk, et al.
Published: (2023-11-01)

Novel Neutralizing Epitope of PEDV S1 Protein Identified by IgM Monoclonal Antibody
by: Techit Thavorasak, et al.
Published: (2022-01-01)

Determining the SARS-CoV-2 Anti-Spike Cutoff Level Denoting Neutralizing Activity Using Two Commercial Kits
by: Engy Mohamed El-Ghitany, et al.
Published: (2022-11-01)

Validation of a SARS-CoV-2 Surrogate Virus Neutralization Test in Recovered and Vaccinated Healthcare Workers
by: Lina Mouna, et al.
Published: (2023-02-01)

Neutralizing Monoclonal Anti-SARS-CoV-2 Antibodies Isolated from Immunized Rabbits Define Novel Vulnerable Spike-Protein Epitope
by: Efi Makdasi, et al.
Published: (2021-03-01)

Anti-SARS-CoV-2 Spike Antibody Titers and Neutralizing Antibodies in Vaccinated Rheumatoid Arthritis Patients
by: Hiroshi Furukawa, et al.
Published: (2022-08-01)

Effect of COVID-19 Vaccination on the Levels of SARS-CoV-2 Neutralizing Antibodies in COVID-19 Naive, Hybrid, and Breakthrough SARS-CoV-2 Recovered Indian Individuals
by: Gujjarlapudi Deepika, et al.
Published: (2023-09-01)

Functional epitopes and neutralizing antibodies of vaccinia virus
by: Fenghao Peng, et al.
Published: (2023-10-01)

Structural Analysis of Neutralizing Epitopes of the SARS-CoV-2 Spike to Guide Therapy and Vaccine Design Strategies
by: Maxwell T. Finkelstein, et al.
Published: (2021-01-01)

Neutralizing and enhancing antibodies against SARS-CoV-2
by: Yafei Liu, et al.
Published: (2022-12-01)

The Screening of Broadly Neutralizing Antibodies Targeting the SARS-CoV-2 Spike Protein by mRNA Immunization in Mice
by: Zhiyin An, et al.
Published: (2023-05-01)

Broadly Neutralizing Bovine Antibodies: Highly Effective New Tools against Evasive Pathogens?
by: Matthew J. Burke, et al.
Published: (2020-04-01)

Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein
by: Shuyuan Zhang, et al.
Published: (2022-09-01)

Five Commercial Immunoassays for SARS-CoV-2 Antibody Determination and Their Comparison and Correlation with the Virus Neutralization Test
by: Václav Šimánek, et al.
Published: (2021-03-01)