IgA in human health and diseases: Potential regulator of commensal microbiota
Gut microbiota has extensive and tremendous impacts on human physiology and pathology. The regulation of microbiota is therefore a cardinal problem for the mutualistic relationship, as both microbial overgrowth and excessive immune reactions toward them could potentially be detrimental to host homeo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1024330/full |
| _version_ | 1828099093603287040 |
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| author | Tadashi Takeuchi Hiroshi Ohno Hiroshi Ohno |
| author_facet | Tadashi Takeuchi Hiroshi Ohno Hiroshi Ohno |
| author_sort | Tadashi Takeuchi |
| collection | DOAJ |
| description | Gut microbiota has extensive and tremendous impacts on human physiology and pathology. The regulation of microbiota is therefore a cardinal problem for the mutualistic relationship, as both microbial overgrowth and excessive immune reactions toward them could potentially be detrimental to host homeostasis. Growing evidence suggests that IgA, the most dominant secretory immunoglobulin in the intestine, regulates the colonization of commensal microbiota, and consequently, the microbiota-mediated intestinal and extra-intestinal diseases. In this review, we discuss the interactions between IgA and gut microbiota particularly relevant to human pathophysiology. We review current knowledge about how IgA regulates gut microbiota in humans and about the molecular mechanisms behind this interaction. We further discuss the potential role of IgA in regulating human diseases by extrapolating experimental findings, suggesting that IgA can be a future therapeutic strategy that functionally modulates gut microbiota. |
| first_indexed | 2024-04-11T08:11:50Z |
| format | Article |
| id | doaj.art-a43a237a44264081bf89266f7ef1a8d1 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T08:11:50Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-a43a237a44264081bf89266f7ef1a8d12022-12-22T04:35:19ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-11-011310.3389/fimmu.2022.10243301024330IgA in human health and diseases: Potential regulator of commensal microbiotaTadashi Takeuchi0Hiroshi Ohno1Hiroshi Ohno2Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, JapanLaboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, JapanGraduate School of Medical Life Science, Yokohama City University, Yokohama, JapanGut microbiota has extensive and tremendous impacts on human physiology and pathology. The regulation of microbiota is therefore a cardinal problem for the mutualistic relationship, as both microbial overgrowth and excessive immune reactions toward them could potentially be detrimental to host homeostasis. Growing evidence suggests that IgA, the most dominant secretory immunoglobulin in the intestine, regulates the colonization of commensal microbiota, and consequently, the microbiota-mediated intestinal and extra-intestinal diseases. In this review, we discuss the interactions between IgA and gut microbiota particularly relevant to human pathophysiology. We review current knowledge about how IgA regulates gut microbiota in humans and about the molecular mechanisms behind this interaction. We further discuss the potential role of IgA in regulating human diseases by extrapolating experimental findings, suggesting that IgA can be a future therapeutic strategy that functionally modulates gut microbiota.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1024330/fullimmunoglobulin Agut microbiotamicrobial metabolitehuman immunologyadaptive immunity |
| spellingShingle | Tadashi Takeuchi Hiroshi Ohno Hiroshi Ohno IgA in human health and diseases: Potential regulator of commensal microbiota Frontiers in Immunology immunoglobulin A gut microbiota microbial metabolite human immunology adaptive immunity |
| title | IgA in human health and diseases: Potential regulator of commensal microbiota |
| title_full | IgA in human health and diseases: Potential regulator of commensal microbiota |
| title_fullStr | IgA in human health and diseases: Potential regulator of commensal microbiota |
| title_full_unstemmed | IgA in human health and diseases: Potential regulator of commensal microbiota |
| title_short | IgA in human health and diseases: Potential regulator of commensal microbiota |
| title_sort | iga in human health and diseases potential regulator of commensal microbiota |
| topic | immunoglobulin A gut microbiota microbial metabolite human immunology adaptive immunity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1024330/full |
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