Factors affecting drug-induced liver injury: antithyroid drugs as instances
Methimazole and propylthiouracil have been used in the management of hyperthyroidism for more than half a century. However, hepatotoxicity is one of the most deleterious side effects associated with these medications. The mechanism(s) of hepatic injury induced by antithyroid agents is not fully reco...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of the Liver
2014-09-01
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| Series: | Clinical and Molecular Hepatology |
| Subjects: | |
| Online Access: | http://e-cmh.org/upload/pdf/cmh-20-237.pdf |
| _version_ | 1818945965842759680 |
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| author | Reza Heidari Hossein Niknahad Akram Jamshidzadeh Narges Abdoli |
| author_facet | Reza Heidari Hossein Niknahad Akram Jamshidzadeh Narges Abdoli |
| author_sort | Reza Heidari |
| collection | DOAJ |
| description | Methimazole and propylthiouracil have been used in the management of hyperthyroidism for more than half a century. However, hepatotoxicity is one of the most deleterious side effects associated with these medications. The mechanism(s) of hepatic injury induced by antithyroid agents is not fully recognized yet. Furthermore, there are no specific tools for predicting the occurrence of hepatotoxicity induced by these drugs. The purpose of this article is to give an overview on possible susceptibility factors in liver injury induced by antithyroid agents. Age, gender, metabolism characteristics, alcohol consumption, underlying diseases, immunologic mechanisms, and drug interactions are involved in enhancing antithyroid drugs-induced hepatic damage. An outline on the clinically used treatments for antithyroid drugs-induced hepatotoxicity and the potential therapeutic strategies found to be effective against this complication are also discussed. |
| first_indexed | 2024-12-20T08:07:30Z |
| format | Article |
| id | doaj.art-a43c0f2ab91e4c8ab41d9fb74804cafe |
| institution | Directory Open Access Journal |
| issn | 2287-2728 2287-285X |
| language | English |
| last_indexed | 2024-12-20T08:07:30Z |
| publishDate | 2014-09-01 |
| publisher | Korean Association for the Study of the Liver |
| record_format | Article |
| series | Clinical and Molecular Hepatology |
| spelling | doaj.art-a43c0f2ab91e4c8ab41d9fb74804cafe2022-12-21T19:47:22ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2014-09-0120323724810.3350/cmh.2014.20.3.2371086Factors affecting drug-induced liver injury: antithyroid drugs as instancesReza Heidari0Hossein Niknahad1Akram Jamshidzadeh2Narges Abdoli3Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.Pharmacology and Toxicology Department, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.Methimazole and propylthiouracil have been used in the management of hyperthyroidism for more than half a century. However, hepatotoxicity is one of the most deleterious side effects associated with these medications. The mechanism(s) of hepatic injury induced by antithyroid agents is not fully recognized yet. Furthermore, there are no specific tools for predicting the occurrence of hepatotoxicity induced by these drugs. The purpose of this article is to give an overview on possible susceptibility factors in liver injury induced by antithyroid agents. Age, gender, metabolism characteristics, alcohol consumption, underlying diseases, immunologic mechanisms, and drug interactions are involved in enhancing antithyroid drugs-induced hepatic damage. An outline on the clinically used treatments for antithyroid drugs-induced hepatotoxicity and the potential therapeutic strategies found to be effective against this complication are also discussed.http://e-cmh.org/upload/pdf/cmh-20-237.pdfDrug induced liver injury (DILI)EndocrinologyHepatotoxicityIdiosyncratic hepatic injuryRisk factors |
| spellingShingle | Reza Heidari Hossein Niknahad Akram Jamshidzadeh Narges Abdoli Factors affecting drug-induced liver injury: antithyroid drugs as instances Clinical and Molecular Hepatology Drug induced liver injury (DILI) Endocrinology Hepatotoxicity Idiosyncratic hepatic injury Risk factors |
| title | Factors affecting drug-induced liver injury: antithyroid drugs as instances |
| title_full | Factors affecting drug-induced liver injury: antithyroid drugs as instances |
| title_fullStr | Factors affecting drug-induced liver injury: antithyroid drugs as instances |
| title_full_unstemmed | Factors affecting drug-induced liver injury: antithyroid drugs as instances |
| title_short | Factors affecting drug-induced liver injury: antithyroid drugs as instances |
| title_sort | factors affecting drug induced liver injury antithyroid drugs as instances |
| topic | Drug induced liver injury (DILI) Endocrinology Hepatotoxicity Idiosyncratic hepatic injury Risk factors |
| url | http://e-cmh.org/upload/pdf/cmh-20-237.pdf |
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