Comparison of NF-κB from the protists Capsaspora owczarzaki and Acanthoeca spectabilis reveals extensive evolutionary diversification of this transcription factor
Transcription factor NF-ĸB is a key regulator of immunity in mammals, but its function in protists like Capsaspora and choanoflagellates is not known. Here, Leah Williams et al. characterize and compare the structure, activity, and regulation of NF-ĸB from Capsaspora and one choanoflagellate, provid...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-12-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02924-2 |
| _version_ | 1828138728089976832 |
|---|---|
| author | Leah M. Williams Sainetra Sridhar Jason Samaroo Jada Peart Ebubechi K. Adindu Anvitha Addanki Christopher J. DiRusso BB522 Molecular Biology Laboratory Pablo J. Aguirre Carrión Nahomie Rodriguez-Sastre Trevor Siggers Thomas D. Gilmore |
| author_facet | Leah M. Williams Sainetra Sridhar Jason Samaroo Jada Peart Ebubechi K. Adindu Anvitha Addanki Christopher J. DiRusso BB522 Molecular Biology Laboratory Pablo J. Aguirre Carrión Nahomie Rodriguez-Sastre Trevor Siggers Thomas D. Gilmore |
| author_sort | Leah M. Williams |
| collection | DOAJ |
| description | Transcription factor NF-ĸB is a key regulator of immunity in mammals, but its function in protists like Capsaspora and choanoflagellates is not known. Here, Leah Williams et al. characterize and compare the structure, activity, and regulation of NF-ĸB from Capsaspora and one choanoflagellate, providing further insight into the origins of NF-ĸB. |
| first_indexed | 2024-04-11T18:40:58Z |
| format | Article |
| id | doaj.art-a43d1a02e3784cfb97982cdcc7351ace |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-11T18:40:58Z |
| publishDate | 2021-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-a43d1a02e3784cfb97982cdcc7351ace2022-12-22T04:08:58ZengNature PortfolioCommunications Biology2399-36422021-12-014111410.1038/s42003-021-02924-2Comparison of NF-κB from the protists Capsaspora owczarzaki and Acanthoeca spectabilis reveals extensive evolutionary diversification of this transcription factorLeah M. Williams0Sainetra Sridhar1Jason Samaroo2Jada Peart3Ebubechi K. Adindu4Anvitha Addanki5Christopher J. DiRusso6BB522 Molecular Biology Laboratory7Pablo J. Aguirre Carrión8Nahomie Rodriguez-Sastre9Trevor Siggers10Thomas D. Gilmore11Department of Biology, Boston UniversityDepartment of Biology, Boston UniversityDepartment of Biology, Boston UniversityDepartment of Biology, Boston UniversityDepartment of Biology, Boston UniversityDepartment of Biology, Boston UniversityDepartment of Biology, Boston UniversityProgram in Biochemistry & Molecular Biology, Boston UniversityDepartment of Biology, Boston UniversityDepartment of Biology, Boston UniversityDepartment of Biology, Boston UniversityDepartment of Biology, Boston UniversityTranscription factor NF-ĸB is a key regulator of immunity in mammals, but its function in protists like Capsaspora and choanoflagellates is not known. Here, Leah Williams et al. characterize and compare the structure, activity, and regulation of NF-ĸB from Capsaspora and one choanoflagellate, providing further insight into the origins of NF-ĸB.https://doi.org/10.1038/s42003-021-02924-2 |
| spellingShingle | Leah M. Williams Sainetra Sridhar Jason Samaroo Jada Peart Ebubechi K. Adindu Anvitha Addanki Christopher J. DiRusso BB522 Molecular Biology Laboratory Pablo J. Aguirre Carrión Nahomie Rodriguez-Sastre Trevor Siggers Thomas D. Gilmore Comparison of NF-κB from the protists Capsaspora owczarzaki and Acanthoeca spectabilis reveals extensive evolutionary diversification of this transcription factor Communications Biology |
| title | Comparison of NF-κB from the protists Capsaspora owczarzaki and Acanthoeca spectabilis reveals extensive evolutionary diversification of this transcription factor |
| title_full | Comparison of NF-κB from the protists Capsaspora owczarzaki and Acanthoeca spectabilis reveals extensive evolutionary diversification of this transcription factor |
| title_fullStr | Comparison of NF-κB from the protists Capsaspora owczarzaki and Acanthoeca spectabilis reveals extensive evolutionary diversification of this transcription factor |
| title_full_unstemmed | Comparison of NF-κB from the protists Capsaspora owczarzaki and Acanthoeca spectabilis reveals extensive evolutionary diversification of this transcription factor |
| title_short | Comparison of NF-κB from the protists Capsaspora owczarzaki and Acanthoeca spectabilis reveals extensive evolutionary diversification of this transcription factor |
| title_sort | comparison of nf κb from the protists capsaspora owczarzaki and acanthoeca spectabilis reveals extensive evolutionary diversification of this transcription factor |
| url | https://doi.org/10.1038/s42003-021-02924-2 |
| work_keys_str_mv | AT leahmwilliams comparisonofnfkbfromtheprotistscapsasporaowczarzakiandacanthoecaspectabilisrevealsextensiveevolutionarydiversificationofthistranscriptionfactor AT sainetrasridhar comparisonofnfkbfromtheprotistscapsasporaowczarzakiandacanthoecaspectabilisrevealsextensiveevolutionarydiversificationofthistranscriptionfactor AT jasonsamaroo comparisonofnfkbfromtheprotistscapsasporaowczarzakiandacanthoecaspectabilisrevealsextensiveevolutionarydiversificationofthistranscriptionfactor AT jadapeart comparisonofnfkbfromtheprotistscapsasporaowczarzakiandacanthoecaspectabilisrevealsextensiveevolutionarydiversificationofthistranscriptionfactor AT ebubechikadindu comparisonofnfkbfromtheprotistscapsasporaowczarzakiandacanthoecaspectabilisrevealsextensiveevolutionarydiversificationofthistranscriptionfactor AT anvithaaddanki comparisonofnfkbfromtheprotistscapsasporaowczarzakiandacanthoecaspectabilisrevealsextensiveevolutionarydiversificationofthistranscriptionfactor AT christopherjdirusso comparisonofnfkbfromtheprotistscapsasporaowczarzakiandacanthoecaspectabilisrevealsextensiveevolutionarydiversificationofthistranscriptionfactor AT bb522molecularbiologylaboratory comparisonofnfkbfromtheprotistscapsasporaowczarzakiandacanthoecaspectabilisrevealsextensiveevolutionarydiversificationofthistranscriptionfactor AT pablojaguirrecarrion comparisonofnfkbfromtheprotistscapsasporaowczarzakiandacanthoecaspectabilisrevealsextensiveevolutionarydiversificationofthistranscriptionfactor AT nahomierodriguezsastre comparisonofnfkbfromtheprotistscapsasporaowczarzakiandacanthoecaspectabilisrevealsextensiveevolutionarydiversificationofthistranscriptionfactor AT trevorsiggers comparisonofnfkbfromtheprotistscapsasporaowczarzakiandacanthoecaspectabilisrevealsextensiveevolutionarydiversificationofthistranscriptionfactor AT thomasdgilmore comparisonofnfkbfromtheprotistscapsasporaowczarzakiandacanthoecaspectabilisrevealsextensiveevolutionarydiversificationofthistranscriptionfactor |