Human chromatin remodeler cofactor, RNA interactor, eraser and writer sperm RNAs responding to obesity
In the United States almost 33% of adults are considered obese (BMI > 30 kg/m2). Both animal models and to a lesser extent human studies, have associated BMI, a measure of obesity, with alterations in sperm DNA methylation and RNAs. Sperm RNAs from the Assessment of Multiple Gestations from Ovari...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-02-01
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| Series: | Epigenetics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15592294.2019.1644880 |
| _version_ | 1797678904322818048 |
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| author | Grace M. Swanson Molly Estill Michael P. Diamond Richard S. Legro Christos Coutifaris Kurt T. Barnhart Hao Huang Karl R. Hansen J. C. Trussell R. Matthew Coward Heping Zhang Robert Goodrich Stephen A. Krawetz |
| author_facet | Grace M. Swanson Molly Estill Michael P. Diamond Richard S. Legro Christos Coutifaris Kurt T. Barnhart Hao Huang Karl R. Hansen J. C. Trussell R. Matthew Coward Heping Zhang Robert Goodrich Stephen A. Krawetz |
| author_sort | Grace M. Swanson |
| collection | DOAJ |
| description | In the United States almost 33% of adults are considered obese (BMI > 30 kg/m2). Both animal models and to a lesser extent human studies, have associated BMI, a measure of obesity, with alterations in sperm DNA methylation and RNAs. Sperm RNAs from the Assessment of Multiple Gestations from Ovarian Stimulation trial, were isolated and sequenced. A Generalized Linear Model identified 487 BMI associated human sperm RNA elements (short exon-sized sequences). They partitioned into four patterns; a continual increase with BMI, increase once obese (BMI>30 kg/m2); a steady decrease with BMI; and decrease once overweight (BMI 25 - 30 kg/m2). Gene Ontology revealed a unique relationship between BMI and transcripts associated with chromosome organization, adipogenesis, cellular stress and obesity-related inflammation. Coregulatory networks linked by Chromatin remodeler cofactors, RNA interactors, Erasers and Writers (CREWs) were uncovered to reveal a hierarchical epigenetic response pathway. |
| first_indexed | 2024-03-11T23:06:43Z |
| format | Article |
| id | doaj.art-a43e5e59145946e6a1ab8f2caf6f3025 |
| institution | Directory Open Access Journal |
| issn | 1559-2294 1559-2308 |
| language | English |
| last_indexed | 2024-03-11T23:06:43Z |
| publishDate | 2020-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj.art-a43e5e59145946e6a1ab8f2caf6f30252023-09-21T13:09:22ZengTaylor & Francis GroupEpigenetics1559-22941559-23082020-02-01151-2324610.1080/15592294.2019.16448801644880Human chromatin remodeler cofactor, RNA interactor, eraser and writer sperm RNAs responding to obesityGrace M. Swanson0Molly Estill1Michael P. Diamond2Richard S. Legro3Christos Coutifaris4Kurt T. Barnhart5Hao Huang6Karl R. Hansen7J. C. Trussell8R. Matthew Coward9Heping Zhang10Robert Goodrich11Stephen A. Krawetz12Wayne State University School of MedicineWayne State University School of MedicineAugusta UniversityPennsylvania State UniversityUniversity of Pennsylvania School of MedicineUniversity of Pennsylvania School of MedicineYale University School of Public HealthUniversity of Oklahoma College of MedicineUpstate Medical UniversityUniversity of North Carolina School of MedicineYale University School of Public HealthWayne State University School of MedicineWayne State University School of MedicineIn the United States almost 33% of adults are considered obese (BMI > 30 kg/m2). Both animal models and to a lesser extent human studies, have associated BMI, a measure of obesity, with alterations in sperm DNA methylation and RNAs. Sperm RNAs from the Assessment of Multiple Gestations from Ovarian Stimulation trial, were isolated and sequenced. A Generalized Linear Model identified 487 BMI associated human sperm RNA elements (short exon-sized sequences). They partitioned into four patterns; a continual increase with BMI, increase once obese (BMI>30 kg/m2); a steady decrease with BMI; and decrease once overweight (BMI 25 - 30 kg/m2). Gene Ontology revealed a unique relationship between BMI and transcripts associated with chromosome organization, adipogenesis, cellular stress and obesity-related inflammation. Coregulatory networks linked by Chromatin remodeler cofactors, RNA interactors, Erasers and Writers (CREWs) were uncovered to reveal a hierarchical epigenetic response pathway.http://dx.doi.org/10.1080/15592294.2019.1644880bmisperm rnaobesitycrews - chromatin remodeler cofactor rna interactor eraser and writer rnas |
| spellingShingle | Grace M. Swanson Molly Estill Michael P. Diamond Richard S. Legro Christos Coutifaris Kurt T. Barnhart Hao Huang Karl R. Hansen J. C. Trussell R. Matthew Coward Heping Zhang Robert Goodrich Stephen A. Krawetz Human chromatin remodeler cofactor, RNA interactor, eraser and writer sperm RNAs responding to obesity Epigenetics bmi sperm rna obesity crews - chromatin remodeler cofactor rna interactor eraser and writer rnas |
| title | Human chromatin remodeler cofactor, RNA interactor, eraser and writer sperm RNAs responding to obesity |
| title_full | Human chromatin remodeler cofactor, RNA interactor, eraser and writer sperm RNAs responding to obesity |
| title_fullStr | Human chromatin remodeler cofactor, RNA interactor, eraser and writer sperm RNAs responding to obesity |
| title_full_unstemmed | Human chromatin remodeler cofactor, RNA interactor, eraser and writer sperm RNAs responding to obesity |
| title_short | Human chromatin remodeler cofactor, RNA interactor, eraser and writer sperm RNAs responding to obesity |
| title_sort | human chromatin remodeler cofactor rna interactor eraser and writer sperm rnas responding to obesity |
| topic | bmi sperm rna obesity crews - chromatin remodeler cofactor rna interactor eraser and writer rnas |
| url | http://dx.doi.org/10.1080/15592294.2019.1644880 |
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