Stimulation of the Angular Gyrus Improves the Level of Consciousness
Background: Navigated repetitive transcranial magnetic stimulation (rTMS) is a promising tool for neuromodulation. In previous studies it has been shown that the activity of the default mode network (DMN) areas, particularly of its key region—the angular gyrus—is positively corre...
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| Format: | Article |
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MDPI AG
2019-05-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/9/5/103 |
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| author | Liudmila Legostaeva Alexandra Poydasheva Elizaveta Iazeva Dmitry Sinitsyn Dmitry Sergeev Ilya Bakulin Dmitry Lagoda Elena Kremneva Sofya Morozova Yulia Ryabinkina Natalia Suponeva Michael Piradov |
| author_facet | Liudmila Legostaeva Alexandra Poydasheva Elizaveta Iazeva Dmitry Sinitsyn Dmitry Sergeev Ilya Bakulin Dmitry Lagoda Elena Kremneva Sofya Morozova Yulia Ryabinkina Natalia Suponeva Michael Piradov |
| author_sort | Liudmila Legostaeva |
| collection | DOAJ |
| description | Background: Navigated repetitive transcranial magnetic stimulation (rTMS) is a promising tool for neuromodulation. In previous studies it has been shown that the activity of the default mode network (DMN) areas, particularly of its key region—the angular gyrus—is positively correlated with the level of consciousness. Our study aimed to explore the effect of rTMS of the angular gyrus as a new approach for disorders of consciousness (DOC) treatment; Methods: A 10-session 2-week high-frequency rTMS protocol was delivered over the left angular gyrus in 38 DOC patients with repeated neurobehavioral assessments obtained at baseline and in 2 days after the stimulation course was complete; Results: 20 Hz-rTMS over left angular gyrus improved the coma recovery scale revised (CRS-R) total score in minimally conscious state (MCS) patients. We observed no effects in vegetative state (VS) patients; and Conclusions: The left angular gyrus is likely to be effective target for rTMS in patients with present signs of consciousness. |
| first_indexed | 2024-12-11T19:14:01Z |
| format | Article |
| id | doaj.art-a43f8254a88f40ce924435a3f0d91cf8 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-12-11T19:14:01Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-a43f8254a88f40ce924435a3f0d91cf82022-12-22T00:53:42ZengMDPI AGBrain Sciences2076-34252019-05-019510310.3390/brainsci9050103brainsci9050103Stimulation of the Angular Gyrus Improves the Level of ConsciousnessLiudmila Legostaeva0Alexandra Poydasheva1Elizaveta Iazeva2Dmitry Sinitsyn3Dmitry Sergeev4Ilya Bakulin5Dmitry Lagoda6Elena Kremneva7Sofya Morozova8Yulia Ryabinkina9Natalia Suponeva10Michael Piradov11Research Center of Neurology, Volokolamskoe shosse, 80, Moscow 125367, RussiaResearch Center of Neurology, Volokolamskoe shosse, 80, Moscow 125367, RussiaResearch Center of Neurology, Volokolamskoe shosse, 80, Moscow 125367, RussiaResearch Center of Neurology, Volokolamskoe shosse, 80, Moscow 125367, RussiaResearch Center of Neurology, Volokolamskoe shosse, 80, Moscow 125367, RussiaResearch Center of Neurology, Volokolamskoe shosse, 80, Moscow 125367, RussiaResearch Center of Neurology, Volokolamskoe shosse, 80, Moscow 125367, RussiaResearch Center of Neurology, Volokolamskoe shosse, 80, Moscow 125367, RussiaResearch Center of Neurology, Volokolamskoe shosse, 80, Moscow 125367, RussiaResearch Center of Neurology, Volokolamskoe shosse, 80, Moscow 125367, RussiaResearch Center of Neurology, Volokolamskoe shosse, 80, Moscow 125367, RussiaResearch Center of Neurology, Volokolamskoe shosse, 80, Moscow 125367, RussiaBackground: Navigated repetitive transcranial magnetic stimulation (rTMS) is a promising tool for neuromodulation. In previous studies it has been shown that the activity of the default mode network (DMN) areas, particularly of its key region—the angular gyrus—is positively correlated with the level of consciousness. Our study aimed to explore the effect of rTMS of the angular gyrus as a new approach for disorders of consciousness (DOC) treatment; Methods: A 10-session 2-week high-frequency rTMS protocol was delivered over the left angular gyrus in 38 DOC patients with repeated neurobehavioral assessments obtained at baseline and in 2 days after the stimulation course was complete; Results: 20 Hz-rTMS over left angular gyrus improved the coma recovery scale revised (CRS-R) total score in minimally conscious state (MCS) patients. We observed no effects in vegetative state (VS) patients; and Conclusions: The left angular gyrus is likely to be effective target for rTMS in patients with present signs of consciousness.https://www.mdpi.com/2076-3425/9/5/103disorders of consciousnessangular gyrusrepetitive transcranial magnetic stimulationneuromodulationvegetative statenon-invasive brain stimulation |
| spellingShingle | Liudmila Legostaeva Alexandra Poydasheva Elizaveta Iazeva Dmitry Sinitsyn Dmitry Sergeev Ilya Bakulin Dmitry Lagoda Elena Kremneva Sofya Morozova Yulia Ryabinkina Natalia Suponeva Michael Piradov Stimulation of the Angular Gyrus Improves the Level of Consciousness Brain Sciences disorders of consciousness angular gyrus repetitive transcranial magnetic stimulation neuromodulation vegetative state non-invasive brain stimulation |
| title | Stimulation of the Angular Gyrus Improves the Level of Consciousness |
| title_full | Stimulation of the Angular Gyrus Improves the Level of Consciousness |
| title_fullStr | Stimulation of the Angular Gyrus Improves the Level of Consciousness |
| title_full_unstemmed | Stimulation of the Angular Gyrus Improves the Level of Consciousness |
| title_short | Stimulation of the Angular Gyrus Improves the Level of Consciousness |
| title_sort | stimulation of the angular gyrus improves the level of consciousness |
| topic | disorders of consciousness angular gyrus repetitive transcranial magnetic stimulation neuromodulation vegetative state non-invasive brain stimulation |
| url | https://www.mdpi.com/2076-3425/9/5/103 |
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