Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate.
The mortality rates of COVID-19 vary widely across countries, but the underlying mechanisms remain unelucidated. We aimed at the elucidation of relationship between gut microbiota and the mortality rates of COVID-19 across countries. Raw sequencing data of 16S rRNA V3-V5 regions of gut microbiota in...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0260451&type=printable |
| _version_ | 1826554700446564352 |
|---|---|
| author | Masaaki Hirayama Hiroshi Nishiwaki Tomonari Hamaguchi Mikako Ito Jun Ueyama Tetsuya Maeda Kenichi Kashihara Yoshio Tsuboi Kinji Ohno |
| author_facet | Masaaki Hirayama Hiroshi Nishiwaki Tomonari Hamaguchi Mikako Ito Jun Ueyama Tetsuya Maeda Kenichi Kashihara Yoshio Tsuboi Kinji Ohno |
| author_sort | Masaaki Hirayama |
| collection | DOAJ |
| description | The mortality rates of COVID-19 vary widely across countries, but the underlying mechanisms remain unelucidated. We aimed at the elucidation of relationship between gut microbiota and the mortality rates of COVID-19 across countries. Raw sequencing data of 16S rRNA V3-V5 regions of gut microbiota in 953 healthy subjects in ten countries were obtained from the public database. We made a generalized linear model (GLM) to predict the COVID-19 mortality rates using gut microbiota. GLM revealed that low genus Collinsella predicted high COVID-19 mortality rates with a markedly low p-value. Unsupervised clustering of gut microbiota in 953 subjects yielded five enterotypes. The mortality rates were increased from enterotypes 1 to 5, whereas the abundances of Collinsella were decreased from enterotypes 1 to 5 except for enterotype 2. Collinsella produces ursodeoxycholate. Ursodeoxycholate was previously reported to inhibit binding of SARS-CoV-2 to angiotensin-converting enzyme 2; suppress pro-inflammatory cytokines like TNF-α, IL-1β, IL-2, IL-4, and IL-6; have antioxidant and anti-apoptotic effects; and increase alveolar fluid clearance in acute respiratory distress syndrome. Ursodeoxycholate produced by Collinsella may prevent COVID-19 infection and ameliorate acute respiratory distress syndrome in COVID-19 by suppressing cytokine storm syndrome. |
| first_indexed | 2024-04-11T20:17:15Z |
| format | Article |
| id | doaj.art-a4427b6e874647a68ff3451e2dcb739f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2025-03-14T07:45:05Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a4427b6e874647a68ff3451e2dcb739f2025-03-03T05:33:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011611e026045110.1371/journal.pone.0260451Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate.Masaaki HirayamaHiroshi NishiwakiTomonari HamaguchiMikako ItoJun UeyamaTetsuya MaedaKenichi KashiharaYoshio TsuboiKinji OhnoThe mortality rates of COVID-19 vary widely across countries, but the underlying mechanisms remain unelucidated. We aimed at the elucidation of relationship between gut microbiota and the mortality rates of COVID-19 across countries. Raw sequencing data of 16S rRNA V3-V5 regions of gut microbiota in 953 healthy subjects in ten countries were obtained from the public database. We made a generalized linear model (GLM) to predict the COVID-19 mortality rates using gut microbiota. GLM revealed that low genus Collinsella predicted high COVID-19 mortality rates with a markedly low p-value. Unsupervised clustering of gut microbiota in 953 subjects yielded five enterotypes. The mortality rates were increased from enterotypes 1 to 5, whereas the abundances of Collinsella were decreased from enterotypes 1 to 5 except for enterotype 2. Collinsella produces ursodeoxycholate. Ursodeoxycholate was previously reported to inhibit binding of SARS-CoV-2 to angiotensin-converting enzyme 2; suppress pro-inflammatory cytokines like TNF-α, IL-1β, IL-2, IL-4, and IL-6; have antioxidant and anti-apoptotic effects; and increase alveolar fluid clearance in acute respiratory distress syndrome. Ursodeoxycholate produced by Collinsella may prevent COVID-19 infection and ameliorate acute respiratory distress syndrome in COVID-19 by suppressing cytokine storm syndrome.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0260451&type=printable |
| spellingShingle | Masaaki Hirayama Hiroshi Nishiwaki Tomonari Hamaguchi Mikako Ito Jun Ueyama Tetsuya Maeda Kenichi Kashihara Yoshio Tsuboi Kinji Ohno Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate. PLoS ONE |
| title | Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate. |
| title_full | Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate. |
| title_fullStr | Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate. |
| title_full_unstemmed | Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate. |
| title_short | Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate. |
| title_sort | intestinal collinsella may mitigate infection and exacerbation of covid 19 by producing ursodeoxycholate |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0260451&type=printable |
| work_keys_str_mv | AT masaakihirayama intestinalcollinsellamaymitigateinfectionandexacerbationofcovid19byproducingursodeoxycholate AT hiroshinishiwaki intestinalcollinsellamaymitigateinfectionandexacerbationofcovid19byproducingursodeoxycholate AT tomonarihamaguchi intestinalcollinsellamaymitigateinfectionandexacerbationofcovid19byproducingursodeoxycholate AT mikakoito intestinalcollinsellamaymitigateinfectionandexacerbationofcovid19byproducingursodeoxycholate AT junueyama intestinalcollinsellamaymitigateinfectionandexacerbationofcovid19byproducingursodeoxycholate AT tetsuyamaeda intestinalcollinsellamaymitigateinfectionandexacerbationofcovid19byproducingursodeoxycholate AT kenichikashihara intestinalcollinsellamaymitigateinfectionandexacerbationofcovid19byproducingursodeoxycholate AT yoshiotsuboi intestinalcollinsellamaymitigateinfectionandexacerbationofcovid19byproducingursodeoxycholate AT kinjiohno intestinalcollinsellamaymitigateinfectionandexacerbationofcovid19byproducingursodeoxycholate |