PREVALENCE OF THALASSEMIA IN THE VIETNAMESE POPULATION AND BUILDING A CLINICAL DECISION SUPPORT SYSTEM FOR PRENATAL SCREENING FOR THALASSEMIA
Background and objectives. Investigating the prevalence of thalassemia in the Vietnamese population, building a clinical decision support system for prenatal screening for thalassemia. Methods. A cross-sectional study was conducted on pregnant women and their husbands visiting Vietnam National H...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2023-04-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/5249 |
| _version_ | 1826906612538802176 |
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| author | Danh Cuong Tran Anh Linh Dang Thi Ngoc Lan Hoang Chi Thanh Nguyen Thi Ngoc Mai Dinh Van Anh Tran Thi Kim Phuong Doan Thi Trang Nguyen |
| author_facet | Danh Cuong Tran Anh Linh Dang Thi Ngoc Lan Hoang Chi Thanh Nguyen Thi Ngoc Mai Dinh Van Anh Tran Thi Kim Phuong Doan Thi Trang Nguyen |
| author_sort | Danh Cuong Tran |
| collection | DOAJ |
| description |
Background and objectives. Investigating the prevalence of thalassemia in the Vietnamese population, building a clinical decision support system for prenatal screening for thalassemia.
Methods. A cross-sectional study was conducted on pregnant women and their husbands visiting Vietnam National Hospital of Obstetrics and Gynecology from October 2020 to December 2021.
Results. The clinical decision support system including 2 different types of systems for prenatal screening for thalassemia (expert system and 4 AI-based CDSS) was built. Accuracy of expert system and AI-based CDSS was compared. The rate of patients with Alpha thalassemia is 10.73%, the rate of patients with beta-thalassemia is 2.24%, and 0.29% of patients carry both alpha-thalassemia and beta-thalassemia gene mutations. The expert system showed an accuracy of 98.45%. Among the AI-based CDSS developed, the MLP model was the most stable regardless of the training database.
Conclusions. When comparing the expert system with the AI-based CDSS, the accuracy of the expert system and AI-based models was found to be comparable. The developed expert system for prenatal thalassemia screening showed high accuracy. AI-based CDSS showed satisfactory results and can be applied in clinical practice.
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| first_indexed | 2024-04-09T15:22:49Z |
| format | Article |
| id | doaj.art-a444ca84e8374d7eaa3be5f5d850dcb8 |
| institution | Directory Open Access Journal |
| issn | 2035-3006 |
| language | English |
| last_indexed | 2025-02-17T08:50:06Z |
| publishDate | 2023-04-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj.art-a444ca84e8374d7eaa3be5f5d850dcb82025-01-02T20:14:53ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062023-04-0115110.4084/MJHID.2023.026PREVALENCE OF THALASSEMIA IN THE VIETNAMESE POPULATION AND BUILDING A CLINICAL DECISION SUPPORT SYSTEM FOR PRENATAL SCREENING FOR THALASSEMIADanh Cuong Tran0Anh Linh Dang1Thi Ngoc Lan Hoang2Chi Thanh Nguyen3Thi Ngoc Mai Dinh4Van Anh Tran5Thi Kim Phuong Doan6Thi Trang Nguyen7National Hospital of Obstetrics and GynecologyNational Hospital of Obstetrics and GynecologyHanoi Medical UniversityAcademy of Military Science and TechnologyHanoi Medical UniversityHanoi Medical UniversityHanoi Medical Universitya:1:{s:5:"en_US";s:24:"Hanoi Medical University";} Background and objectives. Investigating the prevalence of thalassemia in the Vietnamese population, building a clinical decision support system for prenatal screening for thalassemia. Methods. A cross-sectional study was conducted on pregnant women and their husbands visiting Vietnam National Hospital of Obstetrics and Gynecology from October 2020 to December 2021. Results. The clinical decision support system including 2 different types of systems for prenatal screening for thalassemia (expert system and 4 AI-based CDSS) was built. Accuracy of expert system and AI-based CDSS was compared. The rate of patients with Alpha thalassemia is 10.73%, the rate of patients with beta-thalassemia is 2.24%, and 0.29% of patients carry both alpha-thalassemia and beta-thalassemia gene mutations. The expert system showed an accuracy of 98.45%. Among the AI-based CDSS developed, the MLP model was the most stable regardless of the training database. Conclusions. When comparing the expert system with the AI-based CDSS, the accuracy of the expert system and AI-based models was found to be comparable. The developed expert system for prenatal thalassemia screening showed high accuracy. AI-based CDSS showed satisfactory results and can be applied in clinical practice. http://www.mjhid.org/index.php/mjhid/article/view/5249ThalassemiaVietnamese populationclinical decision support systemexpert systemAI-based system |
| spellingShingle | Danh Cuong Tran Anh Linh Dang Thi Ngoc Lan Hoang Chi Thanh Nguyen Thi Ngoc Mai Dinh Van Anh Tran Thi Kim Phuong Doan Thi Trang Nguyen PREVALENCE OF THALASSEMIA IN THE VIETNAMESE POPULATION AND BUILDING A CLINICAL DECISION SUPPORT SYSTEM FOR PRENATAL SCREENING FOR THALASSEMIA Mediterranean Journal of Hematology and Infectious Diseases Thalassemia Vietnamese population clinical decision support system expert system AI-based system |
| title | PREVALENCE OF THALASSEMIA IN THE VIETNAMESE POPULATION AND BUILDING A CLINICAL DECISION SUPPORT SYSTEM FOR PRENATAL SCREENING FOR THALASSEMIA |
| title_full | PREVALENCE OF THALASSEMIA IN THE VIETNAMESE POPULATION AND BUILDING A CLINICAL DECISION SUPPORT SYSTEM FOR PRENATAL SCREENING FOR THALASSEMIA |
| title_fullStr | PREVALENCE OF THALASSEMIA IN THE VIETNAMESE POPULATION AND BUILDING A CLINICAL DECISION SUPPORT SYSTEM FOR PRENATAL SCREENING FOR THALASSEMIA |
| title_full_unstemmed | PREVALENCE OF THALASSEMIA IN THE VIETNAMESE POPULATION AND BUILDING A CLINICAL DECISION SUPPORT SYSTEM FOR PRENATAL SCREENING FOR THALASSEMIA |
| title_short | PREVALENCE OF THALASSEMIA IN THE VIETNAMESE POPULATION AND BUILDING A CLINICAL DECISION SUPPORT SYSTEM FOR PRENATAL SCREENING FOR THALASSEMIA |
| title_sort | prevalence of thalassemia in the vietnamese population and building a clinical decision support system for prenatal screening for thalassemia |
| topic | Thalassemia Vietnamese population clinical decision support system expert system AI-based system |
| url | http://www.mjhid.org/index.php/mjhid/article/view/5249 |
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