Developmental eye motion plasticity after unilateral embryonic ear removal in Xenopus laevis
Summary: Gaze stabilization relies on bilateral mirror-symmetric vestibular endorgans, central circuits, and extraocular motor effectors. Embryonic removal of one inner ear before the formation of these structures was used to evaluate the extent to which motor outputs in the presence of a singular i...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-10-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222014377 |
| _version_ | 1811204875326849024 |
|---|---|
| author | Clayton Gordy Hans Straka |
| author_facet | Clayton Gordy Hans Straka |
| author_sort | Clayton Gordy |
| collection | DOAJ |
| description | Summary: Gaze stabilization relies on bilateral mirror-symmetric vestibular endorgans, central circuits, and extraocular motor effectors. Embryonic removal of one inner ear before the formation of these structures was used to evaluate the extent to which motor outputs in the presence of a singular inner ear can develop. Near-congenital one-eared tadpoles subjected to separate or combinatorial visuo-vestibular motion stimulation exhibited comparable eye movements, though smaller in gain to controls, whereas isolated visuo-motor responses were unaltered. Surprisingly, vestibulo-ocular reflexes were robust during off-direction motion toward the missing ear in most cases and often attenuated during on-direction motion. This bidirectional plasticity of signal encoding appears to occur at the expense of vestibular reflexes during motion in the normally preferential activation direction of the singular ear. Consequently, formation of central vestibulo-motor circuits in one-eared animals likely relies on multi-neuronal homeostatic strategies, including enhanced afferent fiber activity in the attempt to adjust bilateral sensorimotor transformations. |
| first_indexed | 2024-04-12T03:21:01Z |
| format | Article |
| id | doaj.art-a446536745bc4abea658541f20409025 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-12T03:21:01Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-a446536745bc4abea658541f204090252022-12-22T03:49:55ZengElsevieriScience2589-00422022-10-012510105165Developmental eye motion plasticity after unilateral embryonic ear removal in Xenopus laevisClayton Gordy0Hans Straka1Faculty of Biology, Ludwig-Maximilians-University Munich, Großhaderner Str. 2, 82152 Planegg, Germany; Graduate School of Systemic Neurosciences, Ludwig-Maximilians-University Munich, Großhaderner Str. 2, 82152 Planegg, GermanyFaculty of Biology, Ludwig-Maximilians-University Munich, Großhaderner Str. 2, 82152 Planegg, Germany; Corresponding authorSummary: Gaze stabilization relies on bilateral mirror-symmetric vestibular endorgans, central circuits, and extraocular motor effectors. Embryonic removal of one inner ear before the formation of these structures was used to evaluate the extent to which motor outputs in the presence of a singular inner ear can develop. Near-congenital one-eared tadpoles subjected to separate or combinatorial visuo-vestibular motion stimulation exhibited comparable eye movements, though smaller in gain to controls, whereas isolated visuo-motor responses were unaltered. Surprisingly, vestibulo-ocular reflexes were robust during off-direction motion toward the missing ear in most cases and often attenuated during on-direction motion. This bidirectional plasticity of signal encoding appears to occur at the expense of vestibular reflexes during motion in the normally preferential activation direction of the singular ear. Consequently, formation of central vestibulo-motor circuits in one-eared animals likely relies on multi-neuronal homeostatic strategies, including enhanced afferent fiber activity in the attempt to adjust bilateral sensorimotor transformations.http://www.sciencedirect.com/science/article/pii/S2589004222014377Biological sciencesNeuroscienceBehavioral neuroscienceSensory neuroscience |
| spellingShingle | Clayton Gordy Hans Straka Developmental eye motion plasticity after unilateral embryonic ear removal in Xenopus laevis iScience Biological sciences Neuroscience Behavioral neuroscience Sensory neuroscience |
| title | Developmental eye motion plasticity after unilateral embryonic ear removal in Xenopus laevis |
| title_full | Developmental eye motion plasticity after unilateral embryonic ear removal in Xenopus laevis |
| title_fullStr | Developmental eye motion plasticity after unilateral embryonic ear removal in Xenopus laevis |
| title_full_unstemmed | Developmental eye motion plasticity after unilateral embryonic ear removal in Xenopus laevis |
| title_short | Developmental eye motion plasticity after unilateral embryonic ear removal in Xenopus laevis |
| title_sort | developmental eye motion plasticity after unilateral embryonic ear removal in xenopus laevis |
| topic | Biological sciences Neuroscience Behavioral neuroscience Sensory neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222014377 |
| work_keys_str_mv | AT claytongordy developmentaleyemotionplasticityafterunilateralembryonicearremovalinxenopuslaevis AT hansstraka developmentaleyemotionplasticityafterunilateralembryonicearremovalinxenopuslaevis |