Hyperhomocysteinemia in developing age and nutritional aspects of folates: an early cardiovascular risk factor
elevated plasma levels of homocysteine are associated with an increased risk of atherosclerosis and cardiovascular ischemic events. Despite this evidence, however, there are still concerns about the mechanisms(s) by which homocysteine exerts its pro-atherogenic effect, and it is unclear whether the...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2016-02-01
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| Series: | Monaldi Archives for Chest Disease |
| Subjects: | |
| Online Access: | https://www.monaldi-archives.org/index.php/macd/article/view/519 |
| _version_ | 1818332687113388032 |
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| author | Giuseppe Caramia Romualdo Belardinelli |
| author_facet | Giuseppe Caramia Romualdo Belardinelli |
| author_sort | Giuseppe Caramia |
| collection | DOAJ |
| description | elevated plasma levels of homocysteine are associated with an increased risk of atherosclerosis and cardiovascular ischemic events. Despite this evidence, however, there are still concerns about the mechanisms(s) by which homocysteine exerts its pro-atherogenic effect, and it is unclear whether the decreased plasma levels of homocysteine through diet or drugs may be paralleled by a reduction in cardiovascular risk. Experimental studies have shown that many possible mechanisms are implicated in the pro-atherogenic effect of homocysteine. Endothelial function is altered in subjects with hyperhomocysteinemia, and endothelial dysfunction is correlated with plasma levels of homocysteine. Exercise training reduces plasma levels of homocysteine and improves endothelial function, however without evidence of a better outcome. Larger studies are needed in order to demonstrate that the reduction of plasma levels of homocysteine by oral supplementation with folates and vitamins B6 and B12 translates into a decreased incidence of ischemic events, in particular in patients with documented coronary artery disease and ischemic encephalopathy. |
| first_indexed | 2024-12-13T13:39:42Z |
| format | Article |
| id | doaj.art-a447d9240ddf46e5bb09006166f24f71 |
| institution | Directory Open Access Journal |
| issn | 1122-0643 2532-5264 |
| language | English |
| last_indexed | 2024-12-13T13:39:42Z |
| publishDate | 2016-02-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Monaldi Archives for Chest Disease |
| spelling | doaj.art-a447d9240ddf46e5bb09006166f24f712022-12-21T23:43:37ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642016-02-0166410.4081/monaldi.2006.519Hyperhomocysteinemia in developing age and nutritional aspects of folates: an early cardiovascular risk factorGiuseppe Caramia0Romualdo Belardinelli1Azienda Ospedaliera Materno-Infantile “G. Salesi”, AnconaCardiologia Riabilitativa, Presidio Cardiologico “GM Lancisi”, Anconaelevated plasma levels of homocysteine are associated with an increased risk of atherosclerosis and cardiovascular ischemic events. Despite this evidence, however, there are still concerns about the mechanisms(s) by which homocysteine exerts its pro-atherogenic effect, and it is unclear whether the decreased plasma levels of homocysteine through diet or drugs may be paralleled by a reduction in cardiovascular risk. Experimental studies have shown that many possible mechanisms are implicated in the pro-atherogenic effect of homocysteine. Endothelial function is altered in subjects with hyperhomocysteinemia, and endothelial dysfunction is correlated with plasma levels of homocysteine. Exercise training reduces plasma levels of homocysteine and improves endothelial function, however without evidence of a better outcome. Larger studies are needed in order to demonstrate that the reduction of plasma levels of homocysteine by oral supplementation with folates and vitamins B6 and B12 translates into a decreased incidence of ischemic events, in particular in patients with documented coronary artery disease and ischemic encephalopathy.https://www.monaldi-archives.org/index.php/macd/article/view/519hyperhomocysteinemiaarteriosclerotic vascular diseasecardiovascular risk factorsfolic acid5-methyltetrahydrofolate |
| spellingShingle | Giuseppe Caramia Romualdo Belardinelli Hyperhomocysteinemia in developing age and nutritional aspects of folates: an early cardiovascular risk factor Monaldi Archives for Chest Disease hyperhomocysteinemia arteriosclerotic vascular disease cardiovascular risk factors folic acid 5-methyltetrahydrofolate |
| title | Hyperhomocysteinemia in developing age and nutritional aspects of folates: an early cardiovascular risk factor |
| title_full | Hyperhomocysteinemia in developing age and nutritional aspects of folates: an early cardiovascular risk factor |
| title_fullStr | Hyperhomocysteinemia in developing age and nutritional aspects of folates: an early cardiovascular risk factor |
| title_full_unstemmed | Hyperhomocysteinemia in developing age and nutritional aspects of folates: an early cardiovascular risk factor |
| title_short | Hyperhomocysteinemia in developing age and nutritional aspects of folates: an early cardiovascular risk factor |
| title_sort | hyperhomocysteinemia in developing age and nutritional aspects of folates an early cardiovascular risk factor |
| topic | hyperhomocysteinemia arteriosclerotic vascular disease cardiovascular risk factors folic acid 5-methyltetrahydrofolate |
| url | https://www.monaldi-archives.org/index.php/macd/article/view/519 |
| work_keys_str_mv | AT giuseppecaramia hyperhomocysteinemiaindevelopingageandnutritionalaspectsoffolatesanearlycardiovascularriskfactor AT romualdobelardinelli hyperhomocysteinemiaindevelopingageandnutritionalaspectsoffolatesanearlycardiovascularriskfactor |