Maternal prenatal screening programs that predict trisomy 21, trisomy 18, and neural tube defects in offspring
<h4>Objective</h4> To determine the efficacy of three different maternal screening programs (first-trimester screening [FTS], individual second-trimester screening [ISTS], and first- and second-trimester combined screening [FSTCS]) in predicting offspring with trisomy 21, trisomy 18, and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942960/?tool=EBI |
| _version_ | 1797894612610711552 |
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| author | Yiming Chen Wenwen Ning Yezhen Shi Yijie Chen Wen Zhang Liyao Li Xiaoying Wang |
| author_facet | Yiming Chen Wenwen Ning Yezhen Shi Yijie Chen Wen Zhang Liyao Li Xiaoying Wang |
| author_sort | Yiming Chen |
| collection | DOAJ |
| description | <h4>Objective</h4> To determine the efficacy of three different maternal screening programs (first-trimester screening [FTS], individual second-trimester screening [ISTS], and first- and second-trimester combined screening [FSTCS]) in predicting offspring with trisomy 21, trisomy 18, and neural tube defects (NTDs). <h4>Methods</h4> A retrospective cohort involving 108,118 pregnant women who received prenatal screening tests during the first (9–13+6 weeks) and second trimester (15–20+6 weeks) in Hangzhou, China from January–December 2019, as follows: FTS, 72,096; ISTS, 36,022; and FSTCS, 67,631 gravidas. <h4>Result</h4> The high and intermediate risk positivity rates for trisomy 21 screening with FSTCS (2.40% and 5.57%) were lower than ISTS (9.02% and 16.14%) and FTS (2.71% and 7.19%); there were statistically significant differences in the positivity rates among the screening programs (all P < 0.05). Detection of trisomy 21 was as follows: ISTS, 68.75%; FSTCS, 63.64%; and FTS, 48.57%. Detection of trisomy 18 was as follows; FTS and FSTCS, 66.67%; and ISTS, 60.00%. There were no statistical differences in the detection rates for trisomy 21 and 18 among the 3 screening programs (all P > 0.05). The positive predictive values (PPVs) for trisomy 21 and 18 were highest with FTS, while the false positive rate (FPR) was lowest with FSTCS. <h4>Conclusion</h4> FSTCS was superior to FTS and ISTS screening and substantially reduced the number of high risk pregnancies for trisomy 21 and 18; however, FSTCS was not significantly different in detecting fetal trisomy 21 and 18 and other confirmed cases with chromosomal abnormalities. |
| first_indexed | 2024-04-10T07:13:11Z |
| format | Article |
| id | doaj.art-a4481cdfdbd84e89aafa99c12f28062f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T07:13:11Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a4481cdfdbd84e89aafa99c12f28062f2023-02-26T05:31:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01182Maternal prenatal screening programs that predict trisomy 21, trisomy 18, and neural tube defects in offspringYiming ChenWenwen NingYezhen ShiYijie ChenWen ZhangLiyao LiXiaoying Wang<h4>Objective</h4> To determine the efficacy of three different maternal screening programs (first-trimester screening [FTS], individual second-trimester screening [ISTS], and first- and second-trimester combined screening [FSTCS]) in predicting offspring with trisomy 21, trisomy 18, and neural tube defects (NTDs). <h4>Methods</h4> A retrospective cohort involving 108,118 pregnant women who received prenatal screening tests during the first (9–13+6 weeks) and second trimester (15–20+6 weeks) in Hangzhou, China from January–December 2019, as follows: FTS, 72,096; ISTS, 36,022; and FSTCS, 67,631 gravidas. <h4>Result</h4> The high and intermediate risk positivity rates for trisomy 21 screening with FSTCS (2.40% and 5.57%) were lower than ISTS (9.02% and 16.14%) and FTS (2.71% and 7.19%); there were statistically significant differences in the positivity rates among the screening programs (all P < 0.05). Detection of trisomy 21 was as follows: ISTS, 68.75%; FSTCS, 63.64%; and FTS, 48.57%. Detection of trisomy 18 was as follows; FTS and FSTCS, 66.67%; and ISTS, 60.00%. There were no statistical differences in the detection rates for trisomy 21 and 18 among the 3 screening programs (all P > 0.05). The positive predictive values (PPVs) for trisomy 21 and 18 were highest with FTS, while the false positive rate (FPR) was lowest with FSTCS. <h4>Conclusion</h4> FSTCS was superior to FTS and ISTS screening and substantially reduced the number of high risk pregnancies for trisomy 21 and 18; however, FSTCS was not significantly different in detecting fetal trisomy 21 and 18 and other confirmed cases with chromosomal abnormalities.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942960/?tool=EBI |
| spellingShingle | Yiming Chen Wenwen Ning Yezhen Shi Yijie Chen Wen Zhang Liyao Li Xiaoying Wang Maternal prenatal screening programs that predict trisomy 21, trisomy 18, and neural tube defects in offspring PLoS ONE |
| title | Maternal prenatal screening programs that predict trisomy 21, trisomy 18, and neural tube defects in offspring |
| title_full | Maternal prenatal screening programs that predict trisomy 21, trisomy 18, and neural tube defects in offspring |
| title_fullStr | Maternal prenatal screening programs that predict trisomy 21, trisomy 18, and neural tube defects in offspring |
| title_full_unstemmed | Maternal prenatal screening programs that predict trisomy 21, trisomy 18, and neural tube defects in offspring |
| title_short | Maternal prenatal screening programs that predict trisomy 21, trisomy 18, and neural tube defects in offspring |
| title_sort | maternal prenatal screening programs that predict trisomy 21 trisomy 18 and neural tube defects in offspring |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942960/?tool=EBI |
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