Optimization of laser dosimetry based on patient-specific anatomical models for the ablation of pancreatic ductal adenocarcinoma tumor
Abstract Laser-induced thermotherapy has shown promising potential for the treatment of unresectable primary pancreatic ductal adenocarcinoma tumors. Nevertheless, heterogeneous tumor environment and complex thermal interaction phenomena that are established under hyperthermic conditions can lead to...
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Nature Portfolio
2023-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-37859-7 |
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| author | Pouya Namakshenas Francesco Maria Di Matteo Leonardo Bianchi Eliodoro Faiella Serena Stigliano Giuseppe Quero Paola Saccomandi |
| author_facet | Pouya Namakshenas Francesco Maria Di Matteo Leonardo Bianchi Eliodoro Faiella Serena Stigliano Giuseppe Quero Paola Saccomandi |
| author_sort | Pouya Namakshenas |
| collection | DOAJ |
| description | Abstract Laser-induced thermotherapy has shown promising potential for the treatment of unresectable primary pancreatic ductal adenocarcinoma tumors. Nevertheless, heterogeneous tumor environment and complex thermal interaction phenomena that are established under hyperthermic conditions can lead to under/over estimation of laser thermotherapy efficacy. Using numerical modeling, this paper presents an optimized laser setting for Nd:YAG laser delivered by a bare optical fiber (300 µm in diameter) at 1064 nm working in continuous mode within a power range of 2–10 W. For the thermal analysis, patient-specific 3D models were used, consisting of tumors in different portions of the pancreas. The optimized laser power and time for ablating the tumor completely and producing thermal toxic effects on the possible residual tumor cells beyond the tumor margins were found to be 5 W for 550 s, 7 W for 550 s, and 8 W for 550 s for the pancreatic tail, body, and head tumors, respectively. Based on the results, during the laser irradiation at the optimized doses, thermal injury was not evident either in the 15 mm lateral distances from the optical fiber or in the nearby healthy organs. The present computational-based predictions are also in line with the previous ex vivo and in vivo studies, hence, they can assist in the estimation of the therapeutic outcome of laser ablation for pancreatic neoplasms prior to clinical trials. |
| first_indexed | 2024-03-13T00:42:47Z |
| format | Article |
| id | doaj.art-a448e71a021b4b4fa12737d1de0e2656 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T00:42:47Z |
| publishDate | 2023-07-01 |
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| series | Scientific Reports |
| spelling | doaj.art-a448e71a021b4b4fa12737d1de0e26562023-07-09T11:12:45ZengNature PortfolioScientific Reports2045-23222023-07-0113111710.1038/s41598-023-37859-7Optimization of laser dosimetry based on patient-specific anatomical models for the ablation of pancreatic ductal adenocarcinoma tumorPouya Namakshenas0Francesco Maria Di Matteo1Leonardo Bianchi2Eliodoro Faiella3Serena Stigliano4Giuseppe Quero5Paola Saccomandi6Department of Mechanical Engineering, Politecnico di MilanoOperative Endoscopy Department, Fondazione Policlinico Universitario Campus BiomedicoDepartment of Mechanical Engineering, Politecnico di MilanoRadiology Unit, Fondazione Policlinico Universitario Campus BiomedicoOperative Endoscopy Department, Fondazione Policlinico Universitario Campus BiomedicoPancreatic Surgery Unit, Gemelli Pancreatic Advanced Research Center (CRMPG), Fondazione Policlinico Universitario Agostino Gemelli IRCCS di RomaDepartment of Mechanical Engineering, Politecnico di MilanoAbstract Laser-induced thermotherapy has shown promising potential for the treatment of unresectable primary pancreatic ductal adenocarcinoma tumors. Nevertheless, heterogeneous tumor environment and complex thermal interaction phenomena that are established under hyperthermic conditions can lead to under/over estimation of laser thermotherapy efficacy. Using numerical modeling, this paper presents an optimized laser setting for Nd:YAG laser delivered by a bare optical fiber (300 µm in diameter) at 1064 nm working in continuous mode within a power range of 2–10 W. For the thermal analysis, patient-specific 3D models were used, consisting of tumors in different portions of the pancreas. The optimized laser power and time for ablating the tumor completely and producing thermal toxic effects on the possible residual tumor cells beyond the tumor margins were found to be 5 W for 550 s, 7 W for 550 s, and 8 W for 550 s for the pancreatic tail, body, and head tumors, respectively. Based on the results, during the laser irradiation at the optimized doses, thermal injury was not evident either in the 15 mm lateral distances from the optical fiber or in the nearby healthy organs. The present computational-based predictions are also in line with the previous ex vivo and in vivo studies, hence, they can assist in the estimation of the therapeutic outcome of laser ablation for pancreatic neoplasms prior to clinical trials.https://doi.org/10.1038/s41598-023-37859-7 |
| spellingShingle | Pouya Namakshenas Francesco Maria Di Matteo Leonardo Bianchi Eliodoro Faiella Serena Stigliano Giuseppe Quero Paola Saccomandi Optimization of laser dosimetry based on patient-specific anatomical models for the ablation of pancreatic ductal adenocarcinoma tumor Scientific Reports |
| title | Optimization of laser dosimetry based on patient-specific anatomical models for the ablation of pancreatic ductal adenocarcinoma tumor |
| title_full | Optimization of laser dosimetry based on patient-specific anatomical models for the ablation of pancreatic ductal adenocarcinoma tumor |
| title_fullStr | Optimization of laser dosimetry based on patient-specific anatomical models for the ablation of pancreatic ductal adenocarcinoma tumor |
| title_full_unstemmed | Optimization of laser dosimetry based on patient-specific anatomical models for the ablation of pancreatic ductal adenocarcinoma tumor |
| title_short | Optimization of laser dosimetry based on patient-specific anatomical models for the ablation of pancreatic ductal adenocarcinoma tumor |
| title_sort | optimization of laser dosimetry based on patient specific anatomical models for the ablation of pancreatic ductal adenocarcinoma tumor |
| url | https://doi.org/10.1038/s41598-023-37859-7 |
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