Effect of Novel Melanocortin Type 2 Receptor (MC2R) Antagonists on the Corticosterone Response to ACTH in the Neonatal Rat Adrenal Gland in vivo and in vitro.

Effect of Novel Melanocortin Type 2 Receptor (MC2R) Antagonists on the Corticosterone Response to ACTH in the Neonatal Rat Adrenal Gland in vivo and in vitro.

Stress-induced increases in neonatal corticosterone demonstrate a unique shift from ACTH-independence to ACTH-dependence between post-natal day two (PD2) and eight (PD8) in newborn rats. This shift could be due to binding of a bioactive, non-immunoreactive, plasma ligand to the adrenocortical MC2R (...

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Bibliographic Details
Main Authors: Nasha K Nensey, Jonathan eBodager, Ashley L Gehrand, Hershel eRaff
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Endocrinology
Subjects:
Corticosterone
ACTH
adrenal
antagonist
MC2R
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00023/full

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