Duodenal plasmablastic lymphoma in an human immunodeficency virus-negative patient: a case report
Abstract Background Plasmablastic lymphoma is a rare type of non-Hodgkin lymphoma that generally presents an aggressive clinical course. It is strongly associated with human immunodeficency virus (HIV) infection, and the most common site of involvement is the oral cavity. Although extraoral PBL has...
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-023-04143-1 |
| _version_ | 1797452530157879296 |
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| author | Abbas Ali Hussain Aresha Masood Shah Sumeet Kumar |
| author_facet | Abbas Ali Hussain Aresha Masood Shah Sumeet Kumar |
| author_sort | Abbas Ali Hussain |
| collection | DOAJ |
| description | Abstract Background Plasmablastic lymphoma is a rare type of non-Hodgkin lymphoma that generally presents an aggressive clinical course. It is strongly associated with human immunodeficency virus (HIV) infection, and the most common site of involvement is the oral cavity. Although extraoral PBL has been reported in several places, small intestine involvement is extremely rare. Case presentation Here, we describe an exceptionally rare case of a 24-year-old immunocompetent Asian Male patient with newly diagnosed plasmablastic lymphoma of the duodenum. The patient was admitted to our oncology facility due to the patient's clinical course, which included persistent vomiting, hematemesis, weight loss, and generalized weakness. Computed tomography of the abdomen (triphasic) of the patient showed thickness at the 2nd part of the duodenum measuring 2.6 cm in width and 16 cm in length blocking the pancreatic and common bile ducts by entering the second section of the duodenum. The biopsy specimen's pathological investigation indicated abnormal cells with plasmacytoid characteristics and a high proliferation index. The diagnosis of PBL was confirmed by immunohistochemical profiling. Supportive therapies like blood transfusions, antacids, and antiemetics were started to manage the patient's symptoms. Palliative radiation was also anticipated for the lesion site. Conclusions Duodenal involvement to the extent seen in our patient is exceptionally rare and, to the best of our knowledge, has hardly been described. The main goal of the article is to review the literature and report a case. |
| first_indexed | 2024-03-09T15:10:02Z |
| format | Article |
| id | doaj.art-a44a346ab59741f68fb745bd21289c2b |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-03-09T15:10:02Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-a44a346ab59741f68fb745bd21289c2b2023-11-26T13:25:57ZengBMCJournal of Medical Case Reports1752-19472023-10-011711510.1186/s13256-023-04143-1Duodenal plasmablastic lymphoma in an human immunodeficency virus-negative patient: a case reportAbbas Ali Hussain0Aresha Masood Shah1Sumeet Kumar2Jinnah Postgraduate Medical Center JPMCJinnah Postgraduate Medical Center JPMCDow Medical CollegeAbstract Background Plasmablastic lymphoma is a rare type of non-Hodgkin lymphoma that generally presents an aggressive clinical course. It is strongly associated with human immunodeficency virus (HIV) infection, and the most common site of involvement is the oral cavity. Although extraoral PBL has been reported in several places, small intestine involvement is extremely rare. Case presentation Here, we describe an exceptionally rare case of a 24-year-old immunocompetent Asian Male patient with newly diagnosed plasmablastic lymphoma of the duodenum. The patient was admitted to our oncology facility due to the patient's clinical course, which included persistent vomiting, hematemesis, weight loss, and generalized weakness. Computed tomography of the abdomen (triphasic) of the patient showed thickness at the 2nd part of the duodenum measuring 2.6 cm in width and 16 cm in length blocking the pancreatic and common bile ducts by entering the second section of the duodenum. The biopsy specimen's pathological investigation indicated abnormal cells with plasmacytoid characteristics and a high proliferation index. The diagnosis of PBL was confirmed by immunohistochemical profiling. Supportive therapies like blood transfusions, antacids, and antiemetics were started to manage the patient's symptoms. Palliative radiation was also anticipated for the lesion site. Conclusions Duodenal involvement to the extent seen in our patient is exceptionally rare and, to the best of our knowledge, has hardly been described. The main goal of the article is to review the literature and report a case.https://doi.org/10.1186/s13256-023-04143-1Plasmablastic lymphomaDuodenal tumourNon-Hodgkin lymphomaHIVPBL |
| spellingShingle | Abbas Ali Hussain Aresha Masood Shah Sumeet Kumar Duodenal plasmablastic lymphoma in an human immunodeficency virus-negative patient: a case report Journal of Medical Case Reports Plasmablastic lymphoma Duodenal tumour Non-Hodgkin lymphoma HIV PBL |
| title | Duodenal plasmablastic lymphoma in an human immunodeficency virus-negative patient: a case report |
| title_full | Duodenal plasmablastic lymphoma in an human immunodeficency virus-negative patient: a case report |
| title_fullStr | Duodenal plasmablastic lymphoma in an human immunodeficency virus-negative patient: a case report |
| title_full_unstemmed | Duodenal plasmablastic lymphoma in an human immunodeficency virus-negative patient: a case report |
| title_short | Duodenal plasmablastic lymphoma in an human immunodeficency virus-negative patient: a case report |
| title_sort | duodenal plasmablastic lymphoma in an human immunodeficency virus negative patient a case report |
| topic | Plasmablastic lymphoma Duodenal tumour Non-Hodgkin lymphoma HIV PBL |
| url | https://doi.org/10.1186/s13256-023-04143-1 |
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