Insecticide resistance and resistance mechanisms in bed bugs, Cimex spp. (Hemiptera: Cimicidae)
Abstract The worldwide resurgence of bed bugs [both Cimex lectularius L. and Cimex hemipterus (F.)] over the past two decades is believed in large part to be due to the development of insecticide resistance. The transcriptomic and genomic studies since 2010, as well as morphological, biochemical and...
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| Format: | Article |
| Language: | English |
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BMC
2017-06-01
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| Series: | Parasites & Vectors |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13071-017-2232-3 |
| _version_ | 1831659723744608256 |
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| author | Kai Dang Stephen L. Doggett G. Veera Singham Chow-Yang Lee |
| author_facet | Kai Dang Stephen L. Doggett G. Veera Singham Chow-Yang Lee |
| author_sort | Kai Dang |
| collection | DOAJ |
| description | Abstract The worldwide resurgence of bed bugs [both Cimex lectularius L. and Cimex hemipterus (F.)] over the past two decades is believed in large part to be due to the development of insecticide resistance. The transcriptomic and genomic studies since 2010, as well as morphological, biochemical and behavioral studies, have helped insecticide resistance research on bed bugs. Multiple resistance mechanisms, including penetration resistance through thickening or remodelling of the cuticle, metabolic resistance by increased activities of detoxification enzymes (e.g. cytochrome P450 monooxygenases and esterases), and knockdown resistance by kdr mutations, have been experimentally identified as conferring insecticide resistance in bed bugs. Other candidate resistance mechanisms, including behavioral resistance, some types of physiological resistance (e.g. increasing activities of esterases by point mutations, glutathione S-transferase, target site insensitivity including altered AChEs, GABA receptor insensitivity and altered nAChRs), symbiont-mediated resistance and other potential, yet undiscovered mechanisms may exist. This article reviews recent studies of resistance mechanisms and the genes governing insecticide resistance, potential candidate resistance mechanisms, and methods of monitoring insecticide resistance in bed bugs. This article provides an insight into the knowledge essential for the development of both insecticide resistance management (IRM) and integrated pest management (IPM) strategies for successful bed bug management. |
| first_indexed | 2024-12-19T18:03:33Z |
| format | Article |
| id | doaj.art-a44ac062945143c28aeea4c77367630f |
| institution | Directory Open Access Journal |
| issn | 1756-3305 |
| language | English |
| last_indexed | 2024-12-19T18:03:33Z |
| publishDate | 2017-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Parasites & Vectors |
| spelling | doaj.art-a44ac062945143c28aeea4c77367630f2022-12-21T20:11:31ZengBMCParasites & Vectors1756-33052017-06-0110113110.1186/s13071-017-2232-3Insecticide resistance and resistance mechanisms in bed bugs, Cimex spp. (Hemiptera: Cimicidae)Kai Dang0Stephen L. Doggett1G. Veera Singham2Chow-Yang Lee3Urban Entomology Laboratory, Vector Control Research Unit, School of Biological Sciences, Universiti Sains MalaysiaDepartment of Medical Entomology, NSW Health Pathology, Westmead HospitalCentre for Chemical Biology, Universiti Sains MalaysiaUrban Entomology Laboratory, Vector Control Research Unit, School of Biological Sciences, Universiti Sains MalaysiaAbstract The worldwide resurgence of bed bugs [both Cimex lectularius L. and Cimex hemipterus (F.)] over the past two decades is believed in large part to be due to the development of insecticide resistance. The transcriptomic and genomic studies since 2010, as well as morphological, biochemical and behavioral studies, have helped insecticide resistance research on bed bugs. Multiple resistance mechanisms, including penetration resistance through thickening or remodelling of the cuticle, metabolic resistance by increased activities of detoxification enzymes (e.g. cytochrome P450 monooxygenases and esterases), and knockdown resistance by kdr mutations, have been experimentally identified as conferring insecticide resistance in bed bugs. Other candidate resistance mechanisms, including behavioral resistance, some types of physiological resistance (e.g. increasing activities of esterases by point mutations, glutathione S-transferase, target site insensitivity including altered AChEs, GABA receptor insensitivity and altered nAChRs), symbiont-mediated resistance and other potential, yet undiscovered mechanisms may exist. This article reviews recent studies of resistance mechanisms and the genes governing insecticide resistance, potential candidate resistance mechanisms, and methods of monitoring insecticide resistance in bed bugs. This article provides an insight into the knowledge essential for the development of both insecticide resistance management (IRM) and integrated pest management (IPM) strategies for successful bed bug management.http://link.springer.com/article/10.1186/s13071-017-2232-3Bed bugCimex lectulariusCimex hemipterusInsecticide resistanceMechanismMolecular basis |
| spellingShingle | Kai Dang Stephen L. Doggett G. Veera Singham Chow-Yang Lee Insecticide resistance and resistance mechanisms in bed bugs, Cimex spp. (Hemiptera: Cimicidae) Parasites & Vectors Bed bug Cimex lectularius Cimex hemipterus Insecticide resistance Mechanism Molecular basis |
| title | Insecticide resistance and resistance mechanisms in bed bugs, Cimex spp. (Hemiptera: Cimicidae) |
| title_full | Insecticide resistance and resistance mechanisms in bed bugs, Cimex spp. (Hemiptera: Cimicidae) |
| title_fullStr | Insecticide resistance and resistance mechanisms in bed bugs, Cimex spp. (Hemiptera: Cimicidae) |
| title_full_unstemmed | Insecticide resistance and resistance mechanisms in bed bugs, Cimex spp. (Hemiptera: Cimicidae) |
| title_short | Insecticide resistance and resistance mechanisms in bed bugs, Cimex spp. (Hemiptera: Cimicidae) |
| title_sort | insecticide resistance and resistance mechanisms in bed bugs cimex spp hemiptera cimicidae |
| topic | Bed bug Cimex lectularius Cimex hemipterus Insecticide resistance Mechanism Molecular basis |
| url | http://link.springer.com/article/10.1186/s13071-017-2232-3 |
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