Preoperative Serum Metabolites and Potential Biomarkers for Perioperative Cognitive Decline in Elderly Patients
Perioperative cognitive decline is one of the perioperative neurocognitive disorders common to see in elderly patients. Although POCD increases patient mortality and hospitalization time, the exact inflammatory and related mechanisms are still unknown. Besides, the diagnosis of POCD lacks a unified...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-05-01
|
| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.665097/full |
| _version_ | 1818572980955906048 |
|---|---|
| author | Wenbin Lu Zhengyu Jiang Zhengyu Jiang Jie Huang Jinjun Bian Xiya Yu |
| author_facet | Wenbin Lu Zhengyu Jiang Zhengyu Jiang Jie Huang Jinjun Bian Xiya Yu |
| author_sort | Wenbin Lu |
| collection | DOAJ |
| description | Perioperative cognitive decline is one of the perioperative neurocognitive disorders common to see in elderly patients. Although POCD increases patient mortality and hospitalization time, the exact inflammatory and related mechanisms are still unknown. Besides, the diagnosis of POCD lacks a unified and straightforward evaluation neuropsychological scale. Metabolites could reveal chemical fingerprints left behind by the cellular process, which provides a new aspect to understand the biological process behind. According to the post-operative MMSE score, 56 patients who received elective orthopedics surgery were included and divided into POCD and Non-POCD groups. Preoperative serum metabolites in both groups and post-operative serum metabolites were analyzed. We then performed an SVM model using 10 differential metabolites in preoperative samples as features to evaluate the patients' risk of POCD, which appeared to be positively associated with POCD and could be a potential biomarker. We also analyzed differential serum metabolites from preoperative and post-operative samples of POCD patients. By analyzing their overlap differential metabolites with between POCD and Non-POCD patients, we further inferred seven metabolites positively related to the POCD mechanism. Our results provide a more convenient method to aid POCD diagnosis and prevention using biomarkers and explore the possible mechanism behind. |
| first_indexed | 2024-12-15T00:04:59Z |
| format | Article |
| id | doaj.art-a44bf724095a487b8d051cde59807b1a |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-15T00:04:59Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-a44bf724095a487b8d051cde59807b1a2022-12-21T22:42:46ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-05-011210.3389/fpsyt.2021.665097665097Preoperative Serum Metabolites and Potential Biomarkers for Perioperative Cognitive Decline in Elderly PatientsWenbin Lu0Zhengyu Jiang1Zhengyu Jiang2Jie Huang3Jinjun Bian4Xiya Yu5Faculty of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, ChinaFaculty of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Anesthesiology, Naval Medical Center, Naval Medical University, Shanghai, ChinaFaculty of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, ChinaFaculty of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, ChinaFaculty of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, ChinaPerioperative cognitive decline is one of the perioperative neurocognitive disorders common to see in elderly patients. Although POCD increases patient mortality and hospitalization time, the exact inflammatory and related mechanisms are still unknown. Besides, the diagnosis of POCD lacks a unified and straightforward evaluation neuropsychological scale. Metabolites could reveal chemical fingerprints left behind by the cellular process, which provides a new aspect to understand the biological process behind. According to the post-operative MMSE score, 56 patients who received elective orthopedics surgery were included and divided into POCD and Non-POCD groups. Preoperative serum metabolites in both groups and post-operative serum metabolites were analyzed. We then performed an SVM model using 10 differential metabolites in preoperative samples as features to evaluate the patients' risk of POCD, which appeared to be positively associated with POCD and could be a potential biomarker. We also analyzed differential serum metabolites from preoperative and post-operative samples of POCD patients. By analyzing their overlap differential metabolites with between POCD and Non-POCD patients, we further inferred seven metabolites positively related to the POCD mechanism. Our results provide a more convenient method to aid POCD diagnosis and prevention using biomarkers and explore the possible mechanism behind.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.665097/fullpost-operative cognitive declinemetabolomicsanesthesiabiomarkersgeriatric |
| spellingShingle | Wenbin Lu Zhengyu Jiang Zhengyu Jiang Jie Huang Jinjun Bian Xiya Yu Preoperative Serum Metabolites and Potential Biomarkers for Perioperative Cognitive Decline in Elderly Patients Frontiers in Psychiatry post-operative cognitive decline metabolomics anesthesia biomarkers geriatric |
| title | Preoperative Serum Metabolites and Potential Biomarkers for Perioperative Cognitive Decline in Elderly Patients |
| title_full | Preoperative Serum Metabolites and Potential Biomarkers for Perioperative Cognitive Decline in Elderly Patients |
| title_fullStr | Preoperative Serum Metabolites and Potential Biomarkers for Perioperative Cognitive Decline in Elderly Patients |
| title_full_unstemmed | Preoperative Serum Metabolites and Potential Biomarkers for Perioperative Cognitive Decline in Elderly Patients |
| title_short | Preoperative Serum Metabolites and Potential Biomarkers for Perioperative Cognitive Decline in Elderly Patients |
| title_sort | preoperative serum metabolites and potential biomarkers for perioperative cognitive decline in elderly patients |
| topic | post-operative cognitive decline metabolomics anesthesia biomarkers geriatric |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.665097/full |
| work_keys_str_mv | AT wenbinlu preoperativeserummetabolitesandpotentialbiomarkersforperioperativecognitivedeclineinelderlypatients AT zhengyujiang preoperativeserummetabolitesandpotentialbiomarkersforperioperativecognitivedeclineinelderlypatients AT zhengyujiang preoperativeserummetabolitesandpotentialbiomarkersforperioperativecognitivedeclineinelderlypatients AT jiehuang preoperativeserummetabolitesandpotentialbiomarkersforperioperativecognitivedeclineinelderlypatients AT jinjunbian preoperativeserummetabolitesandpotentialbiomarkersforperioperativecognitivedeclineinelderlypatients AT xiyayu preoperativeserummetabolitesandpotentialbiomarkersforperioperativecognitivedeclineinelderlypatients |