Baseline and average platelet count can predict the outcome of patients with aneurysmal subarachnoid hemorrhage
Background: Baseline values and the change of platelet count (PLT) during disease were reported to be associated with prognosis of patients with cancer and intensive care treatment. We aimed to evaluate the association between PLT with the course and prognosis of aneurysmal subarachnoid hemorrhage (...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-04-01
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| Series: | World Neurosurgery: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590139724000334 |
| _version_ | 1797271341006585856 |
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| author | Christoph Rieß Marvin Darkwah Oppong Thiemo-Florin Dinger Jan Rodemerk Laurèl Rauschenbach Meltem Gümüs Benedikt Frank Philipp Dammann Karsten Henning Wrede Ulrich Sure Ramazan Jabbarli |
| author_facet | Christoph Rieß Marvin Darkwah Oppong Thiemo-Florin Dinger Jan Rodemerk Laurèl Rauschenbach Meltem Gümüs Benedikt Frank Philipp Dammann Karsten Henning Wrede Ulrich Sure Ramazan Jabbarli |
| author_sort | Christoph Rieß |
| collection | DOAJ |
| description | Background: Baseline values and the change of platelet count (PLT) during disease were reported to be associated with prognosis of patients with cancer and intensive care treatment. We aimed to evaluate the association between PLT with the course and prognosis of aneurysmal subarachnoid hemorrhage (SAH). Methods: Admission (AdmPLT) and the 14-days mean PLT (MeanPLT) values of 763 SAH patients treated between 01/2005 and 06/2016 were recorded and, for further analysis, divided into four categories: <150, 150–260, 261–400 and > 400 × 109/L. Primary endpoints were cerebral infarcts in follow-up computed tomography scans, in-hospital mortality and unfavorable outcome at 6-months follow-up defined as modified Rankin scale>3. Adverse events during SAH were assessed as secondary endpoints. Results: Higher PLT values were independently associated with lower risk of cerebral infarction (MeanPLT: aOR = 0.65 per-PLT-category-increase, p = 0.001), in-hospital mortality (AdmPLT: aOR = 0.64, p = 0.017; MeanPLT: aOR = 0.23, p < 0.0001) and unfavorable outcome (AdmPLT: aOR = 0.70, p = 0.031; MeanPLT: aOR = 0.35, p < 0.0001). Moreover, individuals with poorer outcome were less prone to PLT increase during SAH (mean values: -+20.3 vs + 30.5 × 109/L for cerebral infarction; +9.3 vs + 32.8 × 109/L for in-hospital mortality; +14.4 vs + 31.1 × 109/L for unfavorable outcome). The following adverse events during SAH were related to AdmPLT and/or MeanPLT: non-aneurysm related secondary rebleeding, intracranial hypertension requiring conservative treatment or decompressive craniectomy, sepsis and acute kidney failure. Conclusion: Low PLT at admission and their less prominent increase during SAH were strongly linked with poor outcome of SAH. Further analysis is required to clarify the background of this association and potential therapeutic implications. |
| first_indexed | 2024-03-07T14:00:18Z |
| format | Article |
| id | doaj.art-a44d5c9553d540baab0a66882b4e29ea |
| institution | Directory Open Access Journal |
| issn | 2590-1397 |
| language | English |
| last_indexed | 2024-03-07T14:00:18Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Neurosurgery: X |
| spelling | doaj.art-a44d5c9553d540baab0a66882b4e29ea2024-03-07T05:29:18ZengElsevierWorld Neurosurgery: X2590-13972024-04-0122100302Baseline and average platelet count can predict the outcome of patients with aneurysmal subarachnoid hemorrhageChristoph Rieß0Marvin Darkwah Oppong1Thiemo-Florin Dinger2Jan Rodemerk3Laurèl Rauschenbach4Meltem Gümüs5Benedikt Frank6Philipp Dammann7Karsten Henning Wrede8Ulrich Sure9Ramazan Jabbarli10Department of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; Corresponding author. Department of Neurosurgery and Spine Surgery, University Hospital Essen, D-45147, Essen, Germany.Department of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, 45147, Essen, GermanyDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, GermanyBackground: Baseline values and the change of platelet count (PLT) during disease were reported to be associated with prognosis of patients with cancer and intensive care treatment. We aimed to evaluate the association between PLT with the course and prognosis of aneurysmal subarachnoid hemorrhage (SAH). Methods: Admission (AdmPLT) and the 14-days mean PLT (MeanPLT) values of 763 SAH patients treated between 01/2005 and 06/2016 were recorded and, for further analysis, divided into four categories: <150, 150–260, 261–400 and > 400 × 109/L. Primary endpoints were cerebral infarcts in follow-up computed tomography scans, in-hospital mortality and unfavorable outcome at 6-months follow-up defined as modified Rankin scale>3. Adverse events during SAH were assessed as secondary endpoints. Results: Higher PLT values were independently associated with lower risk of cerebral infarction (MeanPLT: aOR = 0.65 per-PLT-category-increase, p = 0.001), in-hospital mortality (AdmPLT: aOR = 0.64, p = 0.017; MeanPLT: aOR = 0.23, p < 0.0001) and unfavorable outcome (AdmPLT: aOR = 0.70, p = 0.031; MeanPLT: aOR = 0.35, p < 0.0001). Moreover, individuals with poorer outcome were less prone to PLT increase during SAH (mean values: -+20.3 vs + 30.5 × 109/L for cerebral infarction; +9.3 vs + 32.8 × 109/L for in-hospital mortality; +14.4 vs + 31.1 × 109/L for unfavorable outcome). The following adverse events during SAH were related to AdmPLT and/or MeanPLT: non-aneurysm related secondary rebleeding, intracranial hypertension requiring conservative treatment or decompressive craniectomy, sepsis and acute kidney failure. Conclusion: Low PLT at admission and their less prominent increase during SAH were strongly linked with poor outcome of SAH. Further analysis is required to clarify the background of this association and potential therapeutic implications.http://www.sciencedirect.com/science/article/pii/S2590139724000334Platelet countAneurysmatic subarachnoid hemorrhageMortality |
| spellingShingle | Christoph Rieß Marvin Darkwah Oppong Thiemo-Florin Dinger Jan Rodemerk Laurèl Rauschenbach Meltem Gümüs Benedikt Frank Philipp Dammann Karsten Henning Wrede Ulrich Sure Ramazan Jabbarli Baseline and average platelet count can predict the outcome of patients with aneurysmal subarachnoid hemorrhage World Neurosurgery: X Platelet count Aneurysmatic subarachnoid hemorrhage Mortality |
| title | Baseline and average platelet count can predict the outcome of patients with aneurysmal subarachnoid hemorrhage |
| title_full | Baseline and average platelet count can predict the outcome of patients with aneurysmal subarachnoid hemorrhage |
| title_fullStr | Baseline and average platelet count can predict the outcome of patients with aneurysmal subarachnoid hemorrhage |
| title_full_unstemmed | Baseline and average platelet count can predict the outcome of patients with aneurysmal subarachnoid hemorrhage |
| title_short | Baseline and average platelet count can predict the outcome of patients with aneurysmal subarachnoid hemorrhage |
| title_sort | baseline and average platelet count can predict the outcome of patients with aneurysmal subarachnoid hemorrhage |
| topic | Platelet count Aneurysmatic subarachnoid hemorrhage Mortality |
| url | http://www.sciencedirect.com/science/article/pii/S2590139724000334 |
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