Safety and immunogenicity of intramuscular, single-dose V590 (rVSV-SARS-CoV-2 Vaccine) in healthy adults: Results from a phase 1 randomised, double-blind, placebo-controlled, dose-ranging trial

Safety and immunogenicity of intramuscular, single-dose V590 (rVSV-SARS-CoV-2 Vaccine) in healthy adults: Results from a phase 1 randomised, double-blind, placebo-controlled, dose-ranging trial

Summary: Background: Vaccines against COVID-19 are needed to overcome challenges associated with mitigating the global pandemic. We report the safety and immunogenicity of V590, a live recombinant vesicular stomatitis virus-based COVID-19 vaccine candidate. Methods: In this placebo-controlled, doub...

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Bibliographic Details
Main Authors: Jonathan A. Robbins, Dereck Tait, Qinlei Huang, Sheri Dubey, Tami Crumley, Josee Cote, Julie Luk, Jeffrey R. Sachs, Kathryn Rutkowski, Harriet Park, Robert Schwab, William Joseph Howitt, Juan Carlos Rondon, Martha Hernandez-Illas, Terry O'Reilly, William Smith, Jakub Simon, Cathy Hardalo, Xuemei Zhao, Richard Wnek, Alethea Cope, Eseng Lai, Paula Annunziato, Dalya Guris, S. Aubrey Stoch
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:EBioMedicine
Subjects:
SARS-CoV-2
COVID-19
Vaccine
V590
Vesicular stomatitis virus (VSV)
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642200319X

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