Heart rate‐corrected QT interval: A novel diagnostic biomarker for diabetic peripheral neuropathy
Abstract Aims/Introduction To explore the relationship between heart rate‐corrected QT (QTc) interval and diabetic peripheral neuropathy (DPN), and whether QTc interval has diagnostic utility for DPN beyond nerve conduction velocity. Materials and Methods A total of 965 patients with diabetes, inclu...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-05-01
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| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.13738 |
| _version_ | 1811338604071354368 |
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| author | Ai‐jun Jiang Heng Gu Zhan‐rong Feng Ying Ding Xiao‐hua Xu Guo‐ping Yin Wen‐li Zhang Zi‐yang Shen Qian Li |
| author_facet | Ai‐jun Jiang Heng Gu Zhan‐rong Feng Ying Ding Xiao‐hua Xu Guo‐ping Yin Wen‐li Zhang Zi‐yang Shen Qian Li |
| author_sort | Ai‐jun Jiang |
| collection | DOAJ |
| description | Abstract Aims/Introduction To explore the relationship between heart rate‐corrected QT (QTc) interval and diabetic peripheral neuropathy (DPN), and whether QTc interval has diagnostic utility for DPN beyond nerve conduction velocity. Materials and Methods A total of 965 patients with diabetes, including 473 patients with DPN and 492 patients without DPN, underwent standard 12‐lead electrocardiography and detailed assessments of peripheral neuropathy. Results Patients with DPN had longer QTc intervals than those without. Among participants, from the first to fourth quartile of QTc interval, the proportion of patients with DPN appreciably increased and the nerve conduction velocity obviously decreased (P for trend <0.001). The univariate and multivariate analyses showed that prolonged QTc interval was closely associated with increased risk of DPN (univariable odds ratio 1.112, 95% confidence interval 1.097–1.127, P < 0.001; multivariable odds ratio 1.118, 95% confidence interval 1.099–1.137, P < 0.001). Receiver operating characteristic analysis for the diagnosis of DPN showed a greater area under the curve for QTc interval of 0.894 than the median nerve motor conduction velocity of 0.691, median nerve sensory conduction velocity of 0.664 and peroneal nerve motor conduction velocity of 0.692. The optimal cut‐off point of QTc interval for DPN was 428.5 ms with sensitivity of 0.715 and specificity of 0.920 (P < 0.001). The combination of QTc interval and nerve conduction testing increased the area under the curve for the diagnosis of DPN (from 0.736 to 0.916; P < 0.001). Conclusions QTc interval with 428.5 ms has more reliable diagnostic utility for DPN than nerve conduction velocity, and prolonged QTc interval is closely associated with an increased risk of DPN. |
| first_indexed | 2024-04-13T18:13:32Z |
| format | Article |
| id | doaj.art-a4504f08a5da4c28b323b180049fc8a9 |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-04-13T18:13:32Z |
| publishDate | 2022-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-a4504f08a5da4c28b323b180049fc8a92022-12-22T02:35:49ZengWileyJournal of Diabetes Investigation2040-11162040-11242022-05-0113585085710.1111/jdi.13738Heart rate‐corrected QT interval: A novel diagnostic biomarker for diabetic peripheral neuropathyAi‐jun Jiang0Heng Gu1Zhan‐rong Feng2Ying Ding3Xiao‐hua Xu4Guo‐ping Yin5Wen‐li Zhang6Zi‐yang Shen7Qian Li8Department of Endocrinology, Nanjing First Hospital Nanjing Medical University Nanjing ChinaNanjing Medical University Nanjing ChinaDepartment of Endocrinology Shuyang Hospital of Traditional Chinese Medicine Suqian ChinaDepartment of Endocrinology Shuyang Hospital of Traditional Chinese Medicine Suqian ChinaDepartment of Endocrinology, Nanjing First Hospital Nanjing Medical University Nanjing ChinaDepartment of Endocrinology, Nanjing First Hospital Nanjing Medical University Nanjing ChinaDepartment of Endocrinology, Nanjing First Hospital Nanjing Medical University Nanjing ChinaDepartment of Endocrinology, Nanjing First Hospital Nanjing Medical University Nanjing ChinaDepartment of Endocrinology, Nanjing First Hospital Nanjing Medical University Nanjing ChinaAbstract Aims/Introduction To explore the relationship between heart rate‐corrected QT (QTc) interval and diabetic peripheral neuropathy (DPN), and whether QTc interval has diagnostic utility for DPN beyond nerve conduction velocity. Materials and Methods A total of 965 patients with diabetes, including 473 patients with DPN and 492 patients without DPN, underwent standard 12‐lead electrocardiography and detailed assessments of peripheral neuropathy. Results Patients with DPN had longer QTc intervals than those without. Among participants, from the first to fourth quartile of QTc interval, the proportion of patients with DPN appreciably increased and the nerve conduction velocity obviously decreased (P for trend <0.001). The univariate and multivariate analyses showed that prolonged QTc interval was closely associated with increased risk of DPN (univariable odds ratio 1.112, 95% confidence interval 1.097–1.127, P < 0.001; multivariable odds ratio 1.118, 95% confidence interval 1.099–1.137, P < 0.001). Receiver operating characteristic analysis for the diagnosis of DPN showed a greater area under the curve for QTc interval of 0.894 than the median nerve motor conduction velocity of 0.691, median nerve sensory conduction velocity of 0.664 and peroneal nerve motor conduction velocity of 0.692. The optimal cut‐off point of QTc interval for DPN was 428.5 ms with sensitivity of 0.715 and specificity of 0.920 (P < 0.001). The combination of QTc interval and nerve conduction testing increased the area under the curve for the diagnosis of DPN (from 0.736 to 0.916; P < 0.001). Conclusions QTc interval with 428.5 ms has more reliable diagnostic utility for DPN than nerve conduction velocity, and prolonged QTc interval is closely associated with an increased risk of DPN.https://doi.org/10.1111/jdi.13738DiabetesDiabetic peripheral neuropathyDiagnosis |
| spellingShingle | Ai‐jun Jiang Heng Gu Zhan‐rong Feng Ying Ding Xiao‐hua Xu Guo‐ping Yin Wen‐li Zhang Zi‐yang Shen Qian Li Heart rate‐corrected QT interval: A novel diagnostic biomarker for diabetic peripheral neuropathy Journal of Diabetes Investigation Diabetes Diabetic peripheral neuropathy Diagnosis |
| title | Heart rate‐corrected QT interval: A novel diagnostic biomarker for diabetic peripheral neuropathy |
| title_full | Heart rate‐corrected QT interval: A novel diagnostic biomarker for diabetic peripheral neuropathy |
| title_fullStr | Heart rate‐corrected QT interval: A novel diagnostic biomarker for diabetic peripheral neuropathy |
| title_full_unstemmed | Heart rate‐corrected QT interval: A novel diagnostic biomarker for diabetic peripheral neuropathy |
| title_short | Heart rate‐corrected QT interval: A novel diagnostic biomarker for diabetic peripheral neuropathy |
| title_sort | heart rate corrected qt interval a novel diagnostic biomarker for diabetic peripheral neuropathy |
| topic | Diabetes Diabetic peripheral neuropathy Diagnosis |
| url | https://doi.org/10.1111/jdi.13738 |
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