Salvia miltiorrhiza in Treating Cardiovascular Diseases: A Review on Its Pharmacological and Clinical Applications
Bioactive chemical constitutes from the root of Salvia miltiorrhiza classified in two major groups, viz., liposoluble tanshinones and water-soluble phenolics. Tanshinone IIA is a major lipid-soluble compound having promising health benefits. The in vivo and in vitro studies showed that the tanshinon...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2019.00753/full |
| _version_ | 1811325947058585600 |
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| author | Jie Ren Li Fu Shivraj Hariram Nile Jun Zhang Guoyin Kai Guoyin Kai |
| author_facet | Jie Ren Li Fu Shivraj Hariram Nile Jun Zhang Guoyin Kai Guoyin Kai |
| author_sort | Jie Ren |
| collection | DOAJ |
| description | Bioactive chemical constitutes from the root of Salvia miltiorrhiza classified in two major groups, viz., liposoluble tanshinones and water-soluble phenolics. Tanshinone IIA is a major lipid-soluble compound having promising health benefits. The in vivo and in vitro studies showed that the tanshinone IIA and salvianolate have a wide range of cardiovascular and other pharmacological effects, including antioxidative, anti-inflammatory, endothelial protective, myocardial protective, anticoagulation, vasodilation, and anti-atherosclerosis, as well as significantly help to reduce proliferation and migration of vascular smooth muscle cells. In addition, some of the clinical studies reported that the S. miltiorrhiza preparations in combination with Western medicine were more effective for treatment of various cardiovascular diseases including angina pectoris, myocardial infarction, hypertension, hyperlipidemia, and pulmonary heart diseases. In this review, we demonstrated the potential applications of S. miltiorrhiza, including pharmacological effects of salvianolate, tanshinone IIA, and its water-soluble derivative, like sodium tanshinone IIA sulfonate. Moreover, we also provided details about the clinical applications of S. miltiorrhiza preparations in controlling the cardiovascular diseases. |
| first_indexed | 2024-04-13T14:42:52Z |
| format | Article |
| id | doaj.art-a450fa8c40fe40d99267574cf5b41ee7 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T14:42:52Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-a450fa8c40fe40d99267574cf5b41ee72022-12-22T02:42:52ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122019-07-011010.3389/fphar.2019.00753463061Salvia miltiorrhiza in Treating Cardiovascular Diseases: A Review on Its Pharmacological and Clinical ApplicationsJie Ren0Li Fu1Shivraj Hariram Nile2Jun Zhang3Guoyin Kai4Guoyin Kai5Institute of Plant Biotechnology, School of Life Sciences, Shanghai Normal University, Shanghai, ChinaInstitute of Plant Biotechnology, School of Life Sciences, Shanghai Normal University, Shanghai, ChinaLaboratory of Medicinal Plant Biotechnology, College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, ChinaInstitute of Plant Biotechnology, School of Life Sciences, Shanghai Normal University, Shanghai, ChinaInstitute of Plant Biotechnology, School of Life Sciences, Shanghai Normal University, Shanghai, ChinaLaboratory of Medicinal Plant Biotechnology, College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, ChinaBioactive chemical constitutes from the root of Salvia miltiorrhiza classified in two major groups, viz., liposoluble tanshinones and water-soluble phenolics. Tanshinone IIA is a major lipid-soluble compound having promising health benefits. The in vivo and in vitro studies showed that the tanshinone IIA and salvianolate have a wide range of cardiovascular and other pharmacological effects, including antioxidative, anti-inflammatory, endothelial protective, myocardial protective, anticoagulation, vasodilation, and anti-atherosclerosis, as well as significantly help to reduce proliferation and migration of vascular smooth muscle cells. In addition, some of the clinical studies reported that the S. miltiorrhiza preparations in combination with Western medicine were more effective for treatment of various cardiovascular diseases including angina pectoris, myocardial infarction, hypertension, hyperlipidemia, and pulmonary heart diseases. In this review, we demonstrated the potential applications of S. miltiorrhiza, including pharmacological effects of salvianolate, tanshinone IIA, and its water-soluble derivative, like sodium tanshinone IIA sulfonate. Moreover, we also provided details about the clinical applications of S. miltiorrhiza preparations in controlling the cardiovascular diseases.https://www.frontiersin.org/article/10.3389/fphar.2019.00753/fullcardiovascular diseasesSalvia miltiorrhizaantioxidativeatherosclerosisendothelial protectivemyocardial infarction |
| spellingShingle | Jie Ren Li Fu Shivraj Hariram Nile Jun Zhang Guoyin Kai Guoyin Kai Salvia miltiorrhiza in Treating Cardiovascular Diseases: A Review on Its Pharmacological and Clinical Applications Frontiers in Pharmacology cardiovascular diseases Salvia miltiorrhiza antioxidative atherosclerosis endothelial protective myocardial infarction |
| title | Salvia miltiorrhiza in Treating Cardiovascular Diseases: A Review on Its Pharmacological and Clinical Applications |
| title_full | Salvia miltiorrhiza in Treating Cardiovascular Diseases: A Review on Its Pharmacological and Clinical Applications |
| title_fullStr | Salvia miltiorrhiza in Treating Cardiovascular Diseases: A Review on Its Pharmacological and Clinical Applications |
| title_full_unstemmed | Salvia miltiorrhiza in Treating Cardiovascular Diseases: A Review on Its Pharmacological and Clinical Applications |
| title_short | Salvia miltiorrhiza in Treating Cardiovascular Diseases: A Review on Its Pharmacological and Clinical Applications |
| title_sort | salvia miltiorrhiza in treating cardiovascular diseases a review on its pharmacological and clinical applications |
| topic | cardiovascular diseases Salvia miltiorrhiza antioxidative atherosclerosis endothelial protective myocardial infarction |
| url | https://www.frontiersin.org/article/10.3389/fphar.2019.00753/full |
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