Salicylate Food Intolerance and Aspirin Hypersensitivity in Nasal Polyposis
Background: A clear association between allergy and nasal polyposis (NP) is not determined and the role of food intolerance in patients with NP is not investigated by oral food challenge (OFC). Objective: To investigate the relation of salicylate food intolerance and atopy in patients with NP accord...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2017-03-01
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| Series: | Iranian Journal of Immunology |
| Subjects: | |
| Online Access: | http://iji.sums.ac.ir/article_39292_b08faeb31fc93eaf5ca4aebd00733fa4.pdf |
| _version_ | 1818237120945324032 |
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| author | Hossein Esmaeilzadeh Elmira Esmaeilzadeh Mohammad Faramarzi Mohammad Nabavi Mohammad Farhadi |
| author_facet | Hossein Esmaeilzadeh Elmira Esmaeilzadeh Mohammad Faramarzi Mohammad Nabavi Mohammad Farhadi |
| author_sort | Hossein Esmaeilzadeh |
| collection | DOAJ |
| description | Background: A clear association between allergy and nasal polyposis (NP) is not
determined and the role of food intolerance in patients with NP is not investigated by
oral food challenge (OFC). Objective: To investigate the relation of salicylate food
intolerance and atopy in patients with NP according to recurrence and aspirin
sensitivity. Methods: A cross sectional multicenter study was done in two tertiary
centers for allergy in Iran. Adult patients with NP were selected for the study that had
been referred to allergy clinics. The oral aspirin challenge (OAC) test was performed to
identify aspirin exacerbated respiratory disease (AERD) and the OFC test was used to
investigate food intolerance. Atopic evaluation was performed by skin-prick tests, nasal
smear and blood eosinophil count as well as serum total IgE. Results: One hundred and
nineteen Iranian patients (female to male ratio 1.05) with NP were enrolled (mean age,
38 ± 11 years). Recurrence of nasal polyposis was 64.7%. OAC was performed in all
cases; 43.79% cases had aspirin hypersensitivity. In addition, OFC tests determined that
69.9% of patients had salicylate food allergy. Salicylate food intolerance was
significantly higher in NP cases with AERD than in aspirin tolerant patients (p<0.05).
Yet, positive skin prick test was not associated with NP recurrence and AERD.
Conclusion: Atopy and NSAID exacerbated respiratory disease; therefore, they can
both be considered as predictors of NP recurrence. Our study also showed that salicylate
food intolerance was associated with AERD in nasal polyposis. |
| first_indexed | 2024-12-12T12:20:43Z |
| format | Article |
| id | doaj.art-a4517de5e52546458dd5dfc4b5e42fd8 |
| institution | Directory Open Access Journal |
| issn | 1735-1383 1735-367X |
| language | English |
| last_indexed | 2024-12-12T12:20:43Z |
| publishDate | 2017-03-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Immunology |
| spelling | doaj.art-a4517de5e52546458dd5dfc4b5e42fd82022-12-22T00:24:41ZengShiraz University of Medical SciencesIranian Journal of Immunology1735-13831735-367X2017-03-01141818839292Salicylate Food Intolerance and Aspirin Hypersensitivity in Nasal PolyposisHossein Esmaeilzadeh0Elmira Esmaeilzadeh1Mohammad Faramarzi2Mohammad Nabavi3Mohammad Farhadi4Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Internal Medicine, Division of Rheumatology,Shiraz University of Medical Sciences, Shiraz, IranOtolaryngology Research Center, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Allergy and Immunology, Rasool-e-Akram Hospital,Tehran, Iran6ENT–Head and Neck Surgery Research Center, Iran University of Medical Sciences, Tehran, IranBackground: A clear association between allergy and nasal polyposis (NP) is not determined and the role of food intolerance in patients with NP is not investigated by oral food challenge (OFC). Objective: To investigate the relation of salicylate food intolerance and atopy in patients with NP according to recurrence and aspirin sensitivity. Methods: A cross sectional multicenter study was done in two tertiary centers for allergy in Iran. Adult patients with NP were selected for the study that had been referred to allergy clinics. The oral aspirin challenge (OAC) test was performed to identify aspirin exacerbated respiratory disease (AERD) and the OFC test was used to investigate food intolerance. Atopic evaluation was performed by skin-prick tests, nasal smear and blood eosinophil count as well as serum total IgE. Results: One hundred and nineteen Iranian patients (female to male ratio 1.05) with NP were enrolled (mean age, 38 ± 11 years). Recurrence of nasal polyposis was 64.7%. OAC was performed in all cases; 43.79% cases had aspirin hypersensitivity. In addition, OFC tests determined that 69.9% of patients had salicylate food allergy. Salicylate food intolerance was significantly higher in NP cases with AERD than in aspirin tolerant patients (p<0.05). Yet, positive skin prick test was not associated with NP recurrence and AERD. Conclusion: Atopy and NSAID exacerbated respiratory disease; therefore, they can both be considered as predictors of NP recurrence. Our study also showed that salicylate food intolerance was associated with AERD in nasal polyposis.http://iji.sums.ac.ir/article_39292_b08faeb31fc93eaf5ca4aebd00733fa4.pdfNasal polyposisFood allergyAspirin hypersensitivityRecurrenceSalicylate |
| spellingShingle | Hossein Esmaeilzadeh Elmira Esmaeilzadeh Mohammad Faramarzi Mohammad Nabavi Mohammad Farhadi Salicylate Food Intolerance and Aspirin Hypersensitivity in Nasal Polyposis Iranian Journal of Immunology Nasal polyposis Food allergy Aspirin hypersensitivity Recurrence Salicylate |
| title | Salicylate Food Intolerance and Aspirin Hypersensitivity in Nasal Polyposis |
| title_full | Salicylate Food Intolerance and Aspirin Hypersensitivity in Nasal Polyposis |
| title_fullStr | Salicylate Food Intolerance and Aspirin Hypersensitivity in Nasal Polyposis |
| title_full_unstemmed | Salicylate Food Intolerance and Aspirin Hypersensitivity in Nasal Polyposis |
| title_short | Salicylate Food Intolerance and Aspirin Hypersensitivity in Nasal Polyposis |
| title_sort | salicylate food intolerance and aspirin hypersensitivity in nasal polyposis |
| topic | Nasal polyposis Food allergy Aspirin hypersensitivity Recurrence Salicylate |
| url | http://iji.sums.ac.ir/article_39292_b08faeb31fc93eaf5ca4aebd00733fa4.pdf |
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