Cognitive function in individuals with and without painful and painless diabetic polyneuropathy—A cross‐sectional study in type 1 diabetes
Abstract Introduction Previous studies suggest that cognitive impairment is more prevalent in individuals with painful and painless diabetic peripheral neuropathy (DPN). However, the current evidence is not well described. This study investigated cognitive function in adults with type 1 diabetes mel...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | Endocrinology, Diabetes & Metabolism |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/edm2.420 |
| _version_ | 1797782979120988160 |
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| author | Suganthiya S. Croosu Mimoza Gjela Johan Røikjer Tine M. Hansen Carsten D. Mørch Jens B. Frøkjær Niels Ejskjaer |
| author_facet | Suganthiya S. Croosu Mimoza Gjela Johan Røikjer Tine M. Hansen Carsten D. Mørch Jens B. Frøkjær Niels Ejskjaer |
| author_sort | Suganthiya S. Croosu |
| collection | DOAJ |
| description | Abstract Introduction Previous studies suggest that cognitive impairment is more prevalent in individuals with painful and painless diabetic peripheral neuropathy (DPN). However, the current evidence is not well described. This study investigated cognitive function in adults with type 1 diabetes mellitus (T1DM) and the association to painful/painless DPN and clinical parameters. Methods This cross‐sectional, observational, case–control study included 58 participants with T1DM, sub‐grouped into 20 participants with T1DM and painful DPN, 19 participants with T1DM and painless DPN, 19 participants with T1DM without DPN, and 20 healthy controls were included. The groups were matched for sex and age. The participants performed Addenbrooke's examination III (ACE‐III), which assesses attention, memory, verbal fluency, language and visuospatial skills. Working memory was evaluated using an N‐back task. Cognitive scores were compared between the groups and correlated to age, diabetes duration, HbA1c and nerve conduction measurements. Results Compared to healthy controls, T1DM participants showed lower total ACE‐III (p = .028), memory (p = .013) and language scores (p = .028), together with longer reaction times in the N‐back task (p = .041). Subgroup analyses demonstrated lower memory scores in those with painless DPN compared with healthy controls (p = .013). No differences were observed between the three T1DM subgroups. Cognitive scores and clinical parameters were not associated. Conclusions This study supports the notion of cognitive alterations in T1DM and indicates that cognitive function is altered in T1DM regardless of underlying neuropathic complications. The memory domain appears altered in T1DM, particularly in those with painless DPN. Further studies are needed to verify the findings. |
| first_indexed | 2024-03-13T00:19:35Z |
| format | Article |
| id | doaj.art-a4519eaf9e034f3aad2afe5ea623b2e8 |
| institution | Directory Open Access Journal |
| issn | 2398-9238 |
| language | English |
| last_indexed | 2024-03-13T00:19:35Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism |
| spelling | doaj.art-a4519eaf9e034f3aad2afe5ea623b2e82023-07-11T17:25:36ZengWileyEndocrinology, Diabetes & Metabolism2398-92382023-07-0164n/an/a10.1002/edm2.420Cognitive function in individuals with and without painful and painless diabetic polyneuropathy—A cross‐sectional study in type 1 diabetesSuganthiya S. Croosu0Mimoza Gjela1Johan Røikjer2Tine M. Hansen3Carsten D. Mørch4Jens B. Frøkjær5Niels Ejskjaer6Department of Radiology Aalborg University Hospital Hobrovej 18‐22 9000 Aalborg DenmarkDepartment of Radiology Aalborg University Hospital Hobrovej 18‐22 9000 Aalborg DenmarkSteno Diabetes Center North Denmark Aalborg University Hospital Mølleparkvej 4 9000 Aalborg DenmarkDepartment of Radiology Aalborg University Hospital Hobrovej 18‐22 9000 Aalborg DenmarkCenter for Neuroplasticity and Pain (CNAP), SMI, Department of Health Science and Technology Aalborg University Fredrik Bajers Vej 7D 9220 Aalborg DenmarkDepartment of Radiology Aalborg University Hospital Hobrovej 18‐22 9000 Aalborg DenmarkDepartment of Endocrinology Aalborg University Hospital Mølleparkvej 4 9000 Aalborg DenmarkAbstract Introduction Previous studies suggest that cognitive impairment is more prevalent in individuals with painful and painless diabetic peripheral neuropathy (DPN). However, the current evidence is not well described. This study investigated cognitive function in adults with type 1 diabetes mellitus (T1DM) and the association to painful/painless DPN and clinical parameters. Methods This cross‐sectional, observational, case–control study included 58 participants with T1DM, sub‐grouped into 20 participants with T1DM and painful DPN, 19 participants with T1DM and painless DPN, 19 participants with T1DM without DPN, and 20 healthy controls were included. The groups were matched for sex and age. The participants performed Addenbrooke's examination III (ACE‐III), which assesses attention, memory, verbal fluency, language and visuospatial skills. Working memory was evaluated using an N‐back task. Cognitive scores were compared between the groups and correlated to age, diabetes duration, HbA1c and nerve conduction measurements. Results Compared to healthy controls, T1DM participants showed lower total ACE‐III (p = .028), memory (p = .013) and language scores (p = .028), together with longer reaction times in the N‐back task (p = .041). Subgroup analyses demonstrated lower memory scores in those with painless DPN compared with healthy controls (p = .013). No differences were observed between the three T1DM subgroups. Cognitive scores and clinical parameters were not associated. Conclusions This study supports the notion of cognitive alterations in T1DM and indicates that cognitive function is altered in T1DM regardless of underlying neuropathic complications. The memory domain appears altered in T1DM, particularly in those with painless DPN. Further studies are needed to verify the findings.https://doi.org/10.1002/edm2.420ACE‐IIIcognitive functiondiabetic peripheral neuropathymemoryN‐back taskneuropathic pain |
| spellingShingle | Suganthiya S. Croosu Mimoza Gjela Johan Røikjer Tine M. Hansen Carsten D. Mørch Jens B. Frøkjær Niels Ejskjaer Cognitive function in individuals with and without painful and painless diabetic polyneuropathy—A cross‐sectional study in type 1 diabetes Endocrinology, Diabetes & Metabolism ACE‐III cognitive function diabetic peripheral neuropathy memory N‐back task neuropathic pain |
| title | Cognitive function in individuals with and without painful and painless diabetic polyneuropathy—A cross‐sectional study in type 1 diabetes |
| title_full | Cognitive function in individuals with and without painful and painless diabetic polyneuropathy—A cross‐sectional study in type 1 diabetes |
| title_fullStr | Cognitive function in individuals with and without painful and painless diabetic polyneuropathy—A cross‐sectional study in type 1 diabetes |
| title_full_unstemmed | Cognitive function in individuals with and without painful and painless diabetic polyneuropathy—A cross‐sectional study in type 1 diabetes |
| title_short | Cognitive function in individuals with and without painful and painless diabetic polyneuropathy—A cross‐sectional study in type 1 diabetes |
| title_sort | cognitive function in individuals with and without painful and painless diabetic polyneuropathy a cross sectional study in type 1 diabetes |
| topic | ACE‐III cognitive function diabetic peripheral neuropathy memory N‐back task neuropathic pain |
| url | https://doi.org/10.1002/edm2.420 |
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