Repurposing Riociguat to Target a Novel Paracrine Nitric Oxide-TRPC6 Pathway to Prevent Podocyte Injury

Repurposing Riociguat to Target a Novel Paracrine Nitric Oxide-TRPC6 Pathway to Prevent Podocyte Injury

Increased expression and activity of the Ca<sup>2+</sup> channel transient receptor potential channel 6 (TRPC6) is associated with focal segmental glomerulosclerosis, but therapeutic strategies to target TRPC6 are currently lacking. Nitric oxide (NO) is crucial for normal glomerular func...

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Bibliographic Details
Main Authors: Daan ‘t Hart, Jinhua Li, Johan van der Vlag, Tom Nijenhuis
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
Riociguat
nitric oxide
TRPC6
podocyte injury
focal segmental glomerulosclerosis
Online Access:https://www.mdpi.com/1422-0067/22/22/12485

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