Chrononutrition is associated with melatonin and cortisol rhythm during pregnancy: Findings from MY-CARE cohort study
Chrononutrition has been suggested to have an entrainment effect on circadian rhythm which is crucial for metabolic health. Investigating how chrononutrition affects maternal circadian rhythm can shed light on its role during pregnancy. This study aims to determine chrononutrition characteristics of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.1078086/full |
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| author | Ai Ni Teoh Satvinder Kaur Siti Raihanah Shafie Nurul Husna Mohd Shukri Normina Ahmad Bustami Masaki Takahashi Shigenobu Shibata |
| author_facet | Ai Ni Teoh Satvinder Kaur Siti Raihanah Shafie Nurul Husna Mohd Shukri Normina Ahmad Bustami Masaki Takahashi Shigenobu Shibata |
| author_sort | Ai Ni Teoh |
| collection | DOAJ |
| description | Chrononutrition has been suggested to have an entrainment effect on circadian rhythm which is crucial for metabolic health. Investigating how chrononutrition affects maternal circadian rhythm can shed light on its role during pregnancy. This study aims to determine chrononutrition characteristics of healthy primigravida during pregnancy and its association with melatonin and cortisol rhythm across gestation. A total of 70 healthy primigravidas were recruited from ten randomly selected government maternal and child clinics in Kuala Lumpur, Malaysia. During the second and third trimesters, chrononutrition characteristics including meal timing, frequency, eating window, breakfast skipping, and late-night eating were determined using a 3-day food record. Pregnant women provided salivary samples at five time-points over a 24 h period for melatonin and cortisol assay. Consistently across the second and third trimesters, both melatonin and cortisol showed a rhythmic change over the day. Melatonin levels displayed an increment toward the night whilst cortisol levels declined over the day. Majority observed a shorter eating window (≤12 h) during the second and third trimesters (66 and 55%, respectively). Results showed 23 and 28% skipped breakfast whereas 45 and 37% ate within 2 h pre-bedtime. During the third trimester, a longer eating window was associated with lower melatonin mean (β = –0.40, p = 0.006), peak (β = –0.42, p = 0.006), and AUCG (β = –0.44, p = 0.003). During both trimesters, a lower awakening cortisol level was observed in pregnant women who skipped breakfast (β = –0.33, p = 0.029; β = –0.29, p = 0.044). Only during the second trimester, breakfast-skipping was significantly associated with a greater cortisol amplitude (β = 0.43, p = 0.003). Findings suggest that certain chrononutrition components, particularly eating window and breakfast skipping have a significant influence on maternal melatonin and cortisol rhythm. Dietary intervention targeting these characteristics may be useful in maintaining maternal circadian rhythm. |
| first_indexed | 2024-04-11T00:38:21Z |
| format | Article |
| id | doaj.art-a45711a48c1d42a78f3a45265802172a |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-11T00:38:21Z |
| publishDate | 2023-01-01 |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-a45711a48c1d42a78f3a45265802172a2023-01-06T14:43:03ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-01-01910.3389/fnut.2022.10780861078086Chrononutrition is associated with melatonin and cortisol rhythm during pregnancy: Findings from MY-CARE cohort studyAi Ni Teoh0Satvinder Kaur1Siti Raihanah Shafie2Nurul Husna Mohd Shukri3Normina Ahmad Bustami4Masaki Takahashi5Shigenobu Shibata6Faculty of Applied Sciences, UCSI University, Kuala Lumpur, MalaysiaFaculty of Applied Sciences, UCSI University, Kuala Lumpur, MalaysiaDepartment of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, MalaysiaDepartment of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, MalaysiaFaculty of Medicine and Health Sciences, School of Healthy Aging, Medical Aesthetics and Regenerative Medicine, UCSI University, Kuala Lumpur, MalaysiaInstitute for Liberal Arts, Tokyo Institute of Technology, Tokyo, JapanDepartment of Electrical Engineering and Biosciences, School of Advanced Engineering and Sciences, Waseda University, Tokyo, JapanChrononutrition has been suggested to have an entrainment effect on circadian rhythm which is crucial for metabolic health. Investigating how chrononutrition affects maternal circadian rhythm can shed light on its role during pregnancy. This study aims to determine chrononutrition characteristics of healthy primigravida during pregnancy and its association with melatonin and cortisol rhythm across gestation. A total of 70 healthy primigravidas were recruited from ten randomly selected government maternal and child clinics in Kuala Lumpur, Malaysia. During the second and third trimesters, chrononutrition characteristics including meal timing, frequency, eating window, breakfast skipping, and late-night eating were determined using a 3-day food record. Pregnant women provided salivary samples at five time-points over a 24 h period for melatonin and cortisol assay. Consistently across the second and third trimesters, both melatonin and cortisol showed a rhythmic change over the day. Melatonin levels displayed an increment toward the night whilst cortisol levels declined over the day. Majority observed a shorter eating window (≤12 h) during the second and third trimesters (66 and 55%, respectively). Results showed 23 and 28% skipped breakfast whereas 45 and 37% ate within 2 h pre-bedtime. During the third trimester, a longer eating window was associated with lower melatonin mean (β = –0.40, p = 0.006), peak (β = –0.42, p = 0.006), and AUCG (β = –0.44, p = 0.003). During both trimesters, a lower awakening cortisol level was observed in pregnant women who skipped breakfast (β = –0.33, p = 0.029; β = –0.29, p = 0.044). Only during the second trimester, breakfast-skipping was significantly associated with a greater cortisol amplitude (β = 0.43, p = 0.003). Findings suggest that certain chrononutrition components, particularly eating window and breakfast skipping have a significant influence on maternal melatonin and cortisol rhythm. Dietary intervention targeting these characteristics may be useful in maintaining maternal circadian rhythm.https://www.frontiersin.org/articles/10.3389/fnut.2022.1078086/fullcircadian rhythmmelatonincortisolchrononutritiondietary patternbreakfast skipping |
| spellingShingle | Ai Ni Teoh Satvinder Kaur Siti Raihanah Shafie Nurul Husna Mohd Shukri Normina Ahmad Bustami Masaki Takahashi Shigenobu Shibata Chrononutrition is associated with melatonin and cortisol rhythm during pregnancy: Findings from MY-CARE cohort study Frontiers in Nutrition circadian rhythm melatonin cortisol chrononutrition dietary pattern breakfast skipping |
| title | Chrononutrition is associated with melatonin and cortisol rhythm during pregnancy: Findings from MY-CARE cohort study |
| title_full | Chrononutrition is associated with melatonin and cortisol rhythm during pregnancy: Findings from MY-CARE cohort study |
| title_fullStr | Chrononutrition is associated with melatonin and cortisol rhythm during pregnancy: Findings from MY-CARE cohort study |
| title_full_unstemmed | Chrononutrition is associated with melatonin and cortisol rhythm during pregnancy: Findings from MY-CARE cohort study |
| title_short | Chrononutrition is associated with melatonin and cortisol rhythm during pregnancy: Findings from MY-CARE cohort study |
| title_sort | chrononutrition is associated with melatonin and cortisol rhythm during pregnancy findings from my care cohort study |
| topic | circadian rhythm melatonin cortisol chrononutrition dietary pattern breakfast skipping |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.1078086/full |
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