L-carnitine is an endogenous HDAC inhibitor selectively inhibiting cancer cell growth in vivo and in vitro.

L-carnitine is an endogenous HDAC inhibitor selectively inhibiting cancer cell growth in vivo and in vitro.

L-carnitine (LC) is generally believed to transport long-chain acyl groups from fatty acids into the mitochondrial matrix for ATP generation via the citric acid cycle. Based on Warburg's theory that most cancer cells mainly depend on glycolysis for ATP generation, we hypothesize that, LC treatm...

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Main Authors: Hongbiao Huang, Ningning Liu, Haiping Guo, Siyan Liao, Xiaofen Li, Changshan Yang, Shouting Liu, Wenbin Song, Chunjiao Liu, Lixia Guan, Bing Li, Li Xu, Change Zhang, Xuejun Wang, Q Ping Dou, Jinbao Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3489732?pdf=render

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http://europepmc.org/articles/PMC3489732?pdf=render

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