Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system

Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system

Fibrocytes are monocyte-derived cells implicated in wound healing. Here, the authors utilise single cell RNA-seq, genetic ablation and multiplexed imaging to identify a fibrocyte population in lung cancer models, and use human lung cancer coculture systems to highlight their potential to modulate mi...

Full description

Bibliographic Details
Main Authors: Andreas Weigert, Xiang Zheng, Alina Nenzel, Kati Turkowski, Stefan Günther, Elisabeth Strack, Evelyn Sirait-Fischer, Eiman Elwakeel, Ivan M. Kur, Vandana S. Nikam, Chanil Valasarajan, Hauke Winter, Alexander Wissgott, Robert Voswinkel, Friedrich Grimminger, Bernhard Brüne, Werner Seeger, Soni Savai Pullamsetti, Rajkumar Savai
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33458-8
Description
Summary:Fibrocytes are monocyte-derived cells implicated in wound healing. Here, the authors utilise single cell RNA-seq, genetic ablation and multiplexed imaging to identify a fibrocyte population in lung cancer models, and use human lung cancer coculture systems to highlight their potential to modulate microenvironmental niche and sensitivity to endothelin blockade.
ISSN:2041-1723

Similar Items