Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system
Fibrocytes are monocyte-derived cells implicated in wound healing. Here, the authors utilise single cell RNA-seq, genetic ablation and multiplexed imaging to identify a fibrocyte population in lung cancer models, and use human lung cancer coculture systems to highlight their potential to modulate mi...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33458-8 |
| _version_ | 1798029860365402112 |
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| author | Andreas Weigert Xiang Zheng Alina Nenzel Kati Turkowski Stefan Günther Elisabeth Strack Evelyn Sirait-Fischer Eiman Elwakeel Ivan M. Kur Vandana S. Nikam Chanil Valasarajan Hauke Winter Alexander Wissgott Robert Voswinkel Friedrich Grimminger Bernhard Brüne Werner Seeger Soni Savai Pullamsetti Rajkumar Savai |
| author_facet | Andreas Weigert Xiang Zheng Alina Nenzel Kati Turkowski Stefan Günther Elisabeth Strack Evelyn Sirait-Fischer Eiman Elwakeel Ivan M. Kur Vandana S. Nikam Chanil Valasarajan Hauke Winter Alexander Wissgott Robert Voswinkel Friedrich Grimminger Bernhard Brüne Werner Seeger Soni Savai Pullamsetti Rajkumar Savai |
| author_sort | Andreas Weigert |
| collection | DOAJ |
| description | Fibrocytes are monocyte-derived cells implicated in wound healing. Here, the authors utilise single cell RNA-seq, genetic ablation and multiplexed imaging to identify a fibrocyte population in lung cancer models, and use human lung cancer coculture systems to highlight their potential to modulate microenvironmental niche and sensitivity to endothelin blockade. |
| first_indexed | 2024-04-11T19:32:04Z |
| format | Article |
| id | doaj.art-a45ef476278744d49bbf2334b639d6fb |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T19:32:04Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a45ef476278744d49bbf2334b639d6fb2022-12-22T04:06:58ZengNature PortfolioNature Communications2041-17232022-10-0113112110.1038/s41467-022-33458-8Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin systemAndreas Weigert0Xiang Zheng1Alina Nenzel2Kati Turkowski3Stefan Günther4Elisabeth Strack5Evelyn Sirait-Fischer6Eiman Elwakeel7Ivan M. Kur8Vandana S. Nikam9Chanil Valasarajan10Hauke Winter11Alexander Wissgott12Robert Voswinkel13Friedrich Grimminger14Bernhard Brüne15Werner Seeger16Soni Savai Pullamsetti17Rajkumar Savai18Goethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry IMax Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI)Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI)Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI)Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI)Goethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry IGoethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry IGoethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry IGoethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry IMax Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI)Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI)Translational Lung Research Center (TLRC), Member of the DZL; Department of Thoracic Surgery, Thorax klinik at the University Hospital HeidelbergDepartment of Internal Medicine, Justus-Liebig University Giessen, Member of the DZL, Member of CPIMax Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI)Department of Internal Medicine, Justus-Liebig University Giessen, Member of the DZL, Member of CPIGoethe-University Frankfurt, Faculty of Medicine, Institute of Biochemistry IMax Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI)Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI)Frankfurt Cancer Institute (FCI), Goethe University, and German Cancer Consortium (DKTK), Partner Site FrankfurtFibrocytes are monocyte-derived cells implicated in wound healing. Here, the authors utilise single cell RNA-seq, genetic ablation and multiplexed imaging to identify a fibrocyte population in lung cancer models, and use human lung cancer coculture systems to highlight their potential to modulate microenvironmental niche and sensitivity to endothelin blockade.https://doi.org/10.1038/s41467-022-33458-8 |
| spellingShingle | Andreas Weigert Xiang Zheng Alina Nenzel Kati Turkowski Stefan Günther Elisabeth Strack Evelyn Sirait-Fischer Eiman Elwakeel Ivan M. Kur Vandana S. Nikam Chanil Valasarajan Hauke Winter Alexander Wissgott Robert Voswinkel Friedrich Grimminger Bernhard Brüne Werner Seeger Soni Savai Pullamsetti Rajkumar Savai Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system Nature Communications |
| title | Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system |
| title_full | Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system |
| title_fullStr | Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system |
| title_full_unstemmed | Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system |
| title_short | Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system |
| title_sort | fibrocytes boost tumor supportive phenotypic switches in the lung cancer niche via the endothelin system |
| url | https://doi.org/10.1038/s41467-022-33458-8 |
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